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Biomedical subjects

D Fiedlerová

Publications and source records attributed to D Fiedlerová.

At least 19 recordsLinked to original sources
PubMed1990

HLA antigens in children with epilepsy.

In accord with our results, a significantly higher occurrence of HLA-B17, B27 and A2, B27 haplotype is scrutinized in a total of epileptical children with psoriasis inheritance comparably to the occurrence rate in population (P = 0.05; P = 0.01; P = 0.001). We failed to detect HLA-B13 antigen in our 9 healthy siblings, though this finding was insignificant in our group. Mentioned findings are supporting the suggestion that also HLA-linked genetic factors associated with the type of immune responsiveness may be involved in pathogenesis of epilepsies in our patients. Nevertheless, due to the restricted number of examinations provided, our results are only of tracing value in presuming possible importance of HLA antigenic monitoring in postinflammatory epilepsy, so they cannot give us a satisfactory response. In the next future, it would be suitable to perform these examinations on far larger group of patients including the II. class HLA antigenic assessment.

Child↗
PubMed1989

[Significance of EEG findings in administering anticonvulsant drugs to adults with compensated epilepsy which began in childhood].

Significance of EEG findings for prognosis of further development in paroxysm is evaluated in this work in adult epileptic patients suffering from seizures which appeared in their childhood. The assessment is based on EEG made during the active phase of the disease and in the time when fits were compensated. Seizureless condition after discontinued medication was observed only in a group of patients with secondary type of epilepsy. We suppose these patients should remain under control since two thirds of them showed diffuse nonspecific changes, which means 50% risk of recurrence of seizures after discontinuation of drug therapy. When medication continued, 55% of patients remained without any fits, of this number in 21.6% seizures recurred on the average within seven years after experimental discontinuation of drug therapy in spite of frequently normal EEG findings. The fact that the group of compensated patients without medication did not include those with primarily generalized seizures can be explained by their good conditions observed even in their childhood and for this reason most of them were not treated in the Anti-Paroxysmal Centre.

Adult↗