Search PubMed⌕ Search

Biomedical subjects

D Feist

Publications and source records attributed to D Feist.

At least 37 records · Page 2Linked to original sources
PubMed1979

[Pathogenesis of the neonatal cholestasis syndrome (author's transl)].

Cholestasis means reduced flow of bile between hepatocytes and duodenum. Functional as well as mechanical factors may be important in the pathogenesis of cholestatic syndromes. Extra- and intrahepatic cholestasis can be distinguished. Intrahepatic bile ducts use to be dilated in extrahepatic cholestasis after early infancy; they are however not dilated in obstructive jaundice of the newborn. Neonatal cholestatic syndromes caused by liver cell diseases may in addition cause an obstruction of extrahepatic bile ducts. At the present time most workers in the field do believe that extrahepatic cholestasis in the newborn is rather due to inflammation than to congenital malformation.

Bile Ducts↗
PubMed1979

[Wilson's liver disease in children and adolescents (author's transl)].

Hepatic symptoms are usually the first in Wilson's disease of children and adolescents, while neurologic symptoms and the corneal ring are still missing. Liver lesions due to copper accumulation may develop throughout years without clinical symptoms or biochemical abnormalities. Hemolytic jaundice or gastrointestinal bleeding are the presenting symptoms in some cases. In spite of being a rare syndrom Wilson's disease ought to be considered after hepatitis B or autoimmune liver disease have been excluded as causes of juvenile cirrhosis of the liver. If life-long treatment with D-penicillamin is started in an early stage of Wilson's disease, prognosis is rather good.

Adolescent↗
PubMed1978

Quantitative determination of single serum proteins during acute hepatitis in childhood.

Fifteen serum proteins were estimated by linear immunodiffusion in blood samples from children with acute hepatitis. Blood was drawn at the beginning of the disease and three weeks later. The results were compared with results obtained from a group of age-matched normal children. At the beginning of the disease prealbumin and beta-2-glycoprotein I were depressed, whereas alpha-1-acid-glycoprotein, alpha-1-antitrypsin, cerloplasmin and alpha-2-HS-glycoprotein were found to be elevated. Alpha-2-macroglobulin, transferrin and beta-lipoprotein showed a significant elevation after three weeks. Beta-1-A/C, IgM and IgG remain elevated during time of observation. Albumin, haptoglobin and IgA were similar in patients and controls and did not change during the period of observation.

Acute Disease↗
PubMed1978

[Early diagnosis of Wilson's disease in childhood (author's transl)].

Most of the time Wilson's disease becomes clinically evident in childhood by atypical abdominal symptoms. Therefore early diagnosis is very difficult. In four out of eight patients with Wilson's disease, diagnosed relatively early in the Children's Hospital of Heidelberg University, we could demonstrate that each case of liver disease, which cannot be classified, may be suspicious of Wilson's disease. Even normal levels of ceruloplasmin in serum and copper in urine are not inconsistent with Wilson's disease. There is no screening method in infancy. Fatty liver in school children is very suspicious of Wilson's disease.

Adolescent↗
PubMed1976

[Hypermethioninemia in the differential diagnosis of infantile obstructive jaundice (author's transl)].

In 7 infants suffering from obstructive jaundice we found transient high levels of methionine in serum. All cases had only intrahepatic cholestasis, especially with intrahepatic biliary hypoplasia, whereas other patients with extrahepatic biliary atresia and/or combination of extra- and intrahepatic obstructive jaundice always showed normal levels of methionine. Therefore hypermethioninemia seems to be helpful in differentiating the various causes of infantile obstructive jaundice.

Bile Ducts↗
PubMed1975

[Studies on juvenile chronic hepatitis].

Follow-up study of 40 children suffering from chronic hepatitis. The diagnosis was made by liver needle biopsy with the Menghini method, when clinical signs or laboratory data of liver disease had lasted for more than 6 months. 24 patients showed the histological pattern of the aggressiv type of chronic hepatitis according to the definition of the European Association for the Study of the Liver (1968). In this group only 5 children had autoantibodies in the serum (so-called lupoid hepatitis). The HBAg positive courses played the most important part in the chronic persistent group as well as in the aggressive one. According to literature only the patients with the aggressive type have been treated with prednison, because chronic persistent hepatitis has a good prognosis without any treatment. In nearly all cases high transaminases and gammaglobulin levels decreased during the treatment with prednison, whereas the histological signs of inflammation seldom changed. Cirrhosis of the liver has developed in 2 HBAg positive patients of the aggressive group, who had not consequently received their daily dose of prednison.

Alanine Transaminase↗
PubMed1975

Portal hypertension in children following neonatal umbilical disorders.

10 children presented pre-hepatic portal vein obstruction during their first 6 years of life. 8 of them had massive esophageal varices, 1 died from acute esophageal hemorrhage. The perinatal history of these childre was studied: All of them had an abnormal birth history and all had been hospitalized during their neonatal period. In 5 of them an umbilical infection had been diagnosed, one had an injection of THAM and one other an exchange transfusion through an umbilical vein catheter. Pre-hepatic portal vein occlusion in children is presumed to be mainly an acquired disease resulting from neonatal umbilical disorders.

Child↗
PubMed1975

[Diagnostic and Therapeutical problems of extrahepatic portal vein stenosis].

In seven children the clinical course of extrahepatic portal vein stenosis was studied angiographically. In all children with splenomegaly it was deemed necessary to perform an X-ray barium examination of the oesophagus. Transsplenic portal venography was performed when oesophageal varices were detected to set up the best scheme for emergency treatment. In our patients with hypersplenism there were no specific bone marrow alterations. In contrast to the literature most of our cases had fibrosis of the liver.

Adolescent↗