Biomedical subjects

D Feigl

Publications and source records attributed to D Feigl.

39 records · Page 3Linked to original sources

PubMedDate not supplied

Involvement of the aortic valve cusps in discrete subaortic stenosis.

A review of 18 cases with discrete subaortic stenosis (DSS) revealed that involvement of the aortic valve cusps in the basic process was present in 16. In these 16 cases, extensions of fibroelastic tissue from the site of the DSS toward the base or superior to the base of one or more cusps were seen. In seven of the involved cases, deformity of a cusp was associated with these extensions. Valvular aortic insufficiency in cases with DSS might be caused by extensions of the fibroelastic tissue to the aortic cusps.

Adult↗

PubMedDate not supplied

Painless thyroiditis followed by autoimmune disorders of the thyroid. A case report with biopsy.

Painless thyroiditis is a clinical entity of unknown origin. We report a case of a woman first seen with painless thyroiditis, who consequently developed a true hyperthyroidism, then exophthalmos and finally permanent hypothyroidism. The biopsy findings and serum antibodies determinations at the final stage were of Hashimoto's thyroiditis. The case is discussed and the need for a long follow-up after a painless thyroiditis is stressed.

Adult↗

PubMedDate not supplied

Alkaloids from dendrobatid frogs: structures of two omega-hydroxy congeners of 3-butyl-5-propylindolizidine and occurrence of 2,5-disubstituted pyrrolidines and a 2,6-disubstituted piperidine.

Forty alkaloids were detected and characterized from skin extracts of high- and low-elevation populations of the poison frog Dendrobates histrionicus from northwestern Colombia. Combined gc/ms with NH3 or ND3 in a chemical ionization mode detected protonated parent ions and determined the number of exchangeable NH and OH hydrogens. Six previously unknown dendrobatid alkaloids were characterized. Two were 2,5-disubstituted pyrrolidines, which included pyrrolidine 197B, a trans-2-butyl-5-pentylpyrrolidine, while a third was a 2,6-dipentylpiperidine. Indolizidines 239AB and 239CD had the same relative configuration as the parent alkaloid 223AB [(5E,9E)3-butyl-5-propylindolizidine] and contained, respectively, a omega-hydroxy group in the propyl or butyl side chain. The profiles of alkaloids in the new northern populations of D. histrionicus are typical of the species in containing a set of about eight histrionicotoxins, in marked contrast to a related species, Dendrobates lehmanni, which does not contain histrionicotoxins.

Alkaloids↗