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Biomedical subjects

D F Wilson

Publications and source records attributed to D F Wilson.

At least 325 records · Page 18Linked to original sources
PubMed1970

Energy-coupling mechanisms in mitochondria: kinetic, spectroscopic, and thermodynamic properties of an energy-transducing form of cytochrome b.

The primary event of coupled electron transfer at phosphorylation site II is identified with a modification in one of the two chemically distinct forms of cytochrome b, designated as the energy-transducing cytochrome b(T). This modification is expressed through a change in the redox midpoint potential and by an increase in its reaction half time with cytochrome c(1). In pigeon heart mitochondria cytochrome b(T) exhibits an absorption maximum at 564 nm and on this basis, it can be distinguished from Keilin's cytochrome b which exhibits an absorption maximum at 560 nm and serves as an electron carrier on the substrate side of cytochrome b(T). Kinetic capability of cytochrome b(T) is evidenced by its rapid electron transfer and energization time of less than 200 msec, its thermodynamic capability-by a 280 mV potential span suitable for providing one of the two electron transfer reactions required in ATP formation. Two secondary events of coupled electron flow may be identified with a charge separation across the lipid structure of the permeability barrier and a change in water structure; both events result in an increased 1-anilino-8-naphthalene-sulfonic acid (ANS) response to the altered environment.

Animals↗
PubMed1969

Trasicor in angina pectoris: a double-blind trial.

Eighteen patients entered a double-blind trial of the beta-adrenergic blocking drug Trasicor in the treatment of angina pectoris. Six patients had to be withdrawn from the trial when substitution of placebo for Trasicor caused severe exacerbation of angina attacks. In these cases the frequency and severity of angina attacks fell to a minimum when Trasicor was re-established. A further 10 patients were significantly improved by Trasicor. Two patients showed no significant improvement. No side-effects were observed in doses ranging up to 400 mg. daily.

Adult↗