Search PubMed⌕ Search

Biomedical subjects

D F Su

Publications and source records attributed to D F Su.

33 records · Page 2Linked to original sources
PubMed1992

[Effect of ketanserin on arterial baroreflex-blood pressure control in conscious hypertensive rats].

The effect of ketanserin on arterial baroreflex-blood pressure control (ABR-BP) were studied in conscious freely-moving spontaneously hypertensive rats (SHR) and renovascular hypertensive rats (RVHR). The ABR-BP was measured by using a new method comparing with the pressor responses (in area) to angiotensin II before and after blocking the baroreflex efferent pathway by guanethidine and methyl atropine. It was found that ketanserin enhanced markedly the ABR-BP in both groups of hypertensive rats (SHR: 51% to 74%; RVHR: 59% to 77%). This suggests that the enhancement of ABR-BP may be involved in the anti-hypertensive effects of ketanserin.

Animals↗
PubMed1992

Effects of ketanserin on blood pressure variability in conscious spontaneously hypertensive rats.

Computerized analysis of blood pressure (BP) was used to study for the effects of ketanserin (Ket) on BP and blood pressure variability (BPV). Rats were instrumented chronically and BP was sampled every 4 ms by a computer from 2:00 to 14:00. Then a single dose of Ket (3 mg.kg-1) was given iv. BP and heart period (HP) were recorded for the next 30 min. The results showed that Ket lowered systolic BP (26.7 kPa to 21.1 kPa), diastolic BP (20.5 kPa to 15.8 kPa), and systolic BPV (1.3 kPa to 0.94 kPa). Otherwise, a positive relationship was found between antihypertensive effects of Ket and BPV. These findings may be of importance in antihypertensive treatment.

Animals↗
PubMed1992

[Inhibitory effects of neferine and tetrandrine on portal vein and papillary muscle in rats].

To determine the vascular selectivity, the inhibitory effects of verapamil (Ver), neferine (Nef), and tetrandrine (Tet) on the spontaneous contractile force of portal vein and contractile force of the paced papillary muscle of left ventricle were studied in Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). The vascular selectivity was expressed by the IC50 ratio (IC50 for papillary muscle/IC50 for portal vein). The results showed that the vascular selectivity values of Ver, Nef, and Tet were 1.15, 0.32, and 0.20, respectively in WKY and 0.80, 0.24, and 0.10, respectively in SHR. It is concluded that Nef and Tet, in contrast with Ver which is devoid of selectivity for either tissue, are more liable to inhibit the myocardium than the vascular smooth muscle. In addition, the IC50 value of Tet for inhibition of the portal vein in SHR was nearly 10-fold higher than that in WKY (237 and 27 mumol.L-1, respectively). This indicates that the response of portal vein to Tet is decreased in SHR.

Alkaloids↗
PubMed1992

[Effects of serotonin and norepinephrine on neuronal discharges of the nucleus tractus solitarii in medullary slices].

Effects of serotonin (5-HT) and norepinephrine (NE) on neuronal activities of the nucleus tractus solitarii (NTS) were investigated in rat medullary slice preparations. The spontaneous discharges after perfusion of slices with 5-HT (1 mumol.L-1, 3 min) were increased in 25 (58.1%), reduced in 13 (30.2%), and unchanged in 5 (11.7%) neurons. Afer perfusion of slices with NE (1 mumol.L-1, 3 min), the spontaneous discharges were reduced or ceased in 27 (62.8%), increased in 13 (30.2%), and unchanged in 3 (7.0%) neurons. Responding to both 5-HT and NE were 38 (88.4%) neurons, among which 21 were selected for studying the effect of ketanserin (a new 5-HT2 blocker). The spontaneous discharges were more increased in 10 (47.6%) and reduced in 4 (19.0%) neurons after perfusion of ketanserin+NE than after perfusion of NE alone. These results indicate that there is an interaction between 5-HT2 receptor and alpha 2 adrenoceptor at NTS level, suggesting that the central action of ketanserin may be one of its antihypertensive mechanisms.

Animals↗
PubMed1992

[Effects of silybin on acute myocardial infarction and reperfusion injury in anesthetized rats].

The effects of silybin (Sil) on myocardial infarction size and ischemia- and reperfusion-induced arrhythmias were studied in anesthetized open chest Sprague-Dawley rats. It was found that pretreatment with Sil 20, 50, and 80 mg.kg-1 iv reduced significantly infarct size by 34.7%, 35.0%, and 50.6% respectively at 4 h after ligation. Sil prevented ischemic arrhythmia only at the dose of 80 mg.kg-1. In reperfusion experiment, pretreatment with Sil 20 mg.kg-1 decreased significantly reperfusion-induced arrhythmia.

Animals↗
PubMed1991

[Effects of tetrandrine on hypertensive responses induced by electric stimulation and alpha-adrenoceptor agonists in pithed rats].

Tetrandrine (Tet) 5 mg.kg-1 i.v. inhibited the pressor action of norepinephrine (NE) release induced by electric stimulation (10 V, 0.5-16 Hz) of spinal cord T11-L2. However, Tet 5 mg.kg-1 ia did not obviously attenuate the hypertensive responses to NE 0.51-16.91 micrograms.kg-1 i.v., indicating that Tet did not affect the alpha 1-adrenoceptors-mediated vasoconstriction. Tet 5 mg.kg-1 ia decreased the pressor responses to NE 0.05 and 0.17 micrograms.kg-1 i.v. and markedly reduced the dose-dependent hypertensive responses to B-HT920 i.v., a selective alpha 2-adrenoceptor agonist, proving that Tet reduced alpha 2-adrenoceptors-mediated vasoconstriction.

Adrenergic alpha-Agonists↗
PubMed1989

Evolution with age of baroreflex sensitivity and its autonomic nervous components in conscious hypertensive rats of the Lyon strain.

1. Cardiac baroreflex sensitivity (BRS) and its sympathetic and vagal components were studied after atropine and propranolol administrations in conscious genetically hypertensive (LH), normotensive (LN) and low blood pressure (LL) rats of the Lyon strain at 5, 9, 13 and 70 weeks of age. 2. LH rats older than 9 weeks exhibit a lower BRS than age-matched LN and LL controls. 3. The vagal component of cardiac baroreflex is predominant. In LN rats, this component increases up to 9 weeks of age. 4. The sympathetic component of cardiac baroreflex is small and identical in the three strains and does not alter with age. 5. Thus, in normotensive rats, the increase in BRS during maturation reflects mainly the vagal component. The development of hypertension prevents this physiological increase in the sensitivity of the vagal component of cardiac baroreflex leading to a reduced BRS.

Aging↗
PubMed1988

[Influence of hypertension and age on the sympathetic and parasympathetic components of cardiac baroreflex in the conscious rat].

The influence of blood pressure (BP) level and age on the baroreflex sensitivity (BRS) and its autonomic nervous components was studied in genetically hypertensive (LH), normotensive (LN) and low blood pressure (LL) rats of the Lyon strains at 5, 9, 13 and 70 weeks of age. BRS was computed as the slope of the closest relationship, according to the cardiac response delay, between systolic blood pressure (SBP) and heart period changes induced by phenylephrine injections (3 micrograms/kg, i.v.) BRS and the relative importance of vagal and sympathetic components were determined in 4 conditions: 1) basal; 2) after beta-adrenergic blockade (propranolol, 2 mg/kg i.v.); 3) after vagal blockade (atropine, 2 mg/kg i.v.); 4) after vagal and beta-adrenergic blockade (atropine and propranolol, 2 mg/kg, i.v. each). At 5 weeks of age, BRS did not differ between the 3 strains (0.50 +/- 0.05, 0.69 +/- 0.10 and 0.62 +/- 0.09 ms/mmHg in LH, LN and LL rats respectively). In LN rats, BRS increased sharply between 5 and 9 weeks (1.25 +/- 0.12 ms/mmHg) and then remained stable until 70 weeks of age (1.19 +/- 0.14 ms/mmHg). Such an increase did not occur in LH rats and their BRS value was lower than that of LN and LL controls starting from 9 weeks of age. The vagal component of BRS was found to be more important than the sympathetic one in adult rats whatever the strain (80 p. 100 vs 20 p. 100).(ABSTRACT TRUNCATED AT 250 WORDS)

Aging↗
PubMed1987

[Sensitivity of the cardiac baroreflex in genetically hypertensive rats of a Lyons strain].

To determine precisely the influence of high blood pressure and age on the baroreflex sensitivity (BRS), we measured it in conscious genetically hypertensive (LH), normotensive (LN) and low-blood pressure (LL) rats of the Lyon strains. Groups of male rats were studied at the age of 5, 9, 13, 21 and 40 weeks. Using our previously described technique, their blood pressure (BP) and heart period (HP) were recorded beat by beat, in the conscious unrestrained state. Each animal received 2 or 3 i.v. injections of phenylephrine (PHE, 5 micrograms/kg) and nitroglycerin (NG, 100 micrograms/kg). The BRS (msec/mmHg) was computed as the slope of the closest relationship found between systolic BP (SBP) and HP changes. Otherwise, in the 13-week-old rats, BRS had been measured in basal conditions, after vagal blockade (atropine: 2 mg/kg i.v.) and after beta-adrenergic blockade (propranolol: 2 mg/kg) so as to determine the relative importance of vagal and sympathetic components of the baroreflex. In LN and LL rats, the BRS measured with PHE and NG increased markedly between 5 and 9 weeks of age and then remained stable in LN rats or decreased between 21 and 40 weeks of age in LL rats. In LH rats, BRS remained stable between 5 and 9 weeks of age and increased slightly up to 21 weeks of age. Significant differences between LH and LN rats were observed starting from 9 weeks of age when BRS was measured with PHE and only at 9 weeks of age when it was measured with NG injections. In 13-week-old rats, the cardiac baroreflex response was estimated to depend for 82 p. 100 and 18 p. 100 upon vagal and sympathetic components respectively when BRS was measured with PHE injections and of 68 p. 100 and 32 p. 100 when it was measured with NG injections.(ABSTRACT TRUNCATED AT 250 WORDS)

Age Factors↗
PubMed1987

[Circadian changes in the sensitivity of the baroreflex in the conscious rat].

The cardiac baroreflex sensitivity (BRS) was measured in quiet awake rats after phenylephrine injections. It was shown that BRS progressively increased during daytime (rest period) and decreased at the beginning of the night (activity period). These variations were independent from the levels of blood pressure and heart period recorded before the BRS measurements.

Animals↗
PubMed1986

Blood pressure and baroreflex sensitivity in conscious hypertensive rats of Lyon strain.

The evolution with age of blood pressure (BP), heart rate (HR), and baroreflex sensitivity was studied in hypertensive (LH), normotensive (LN), and low blood pressure (LL) male rats of the Lyon strains. Intra-arterial BP was continuously recorded for 48 h in freely moving animals. On-line computer analysis of the BP curve allowed calculation of systolic (SBP), mean (MAP), and diastolic (DBP) blood pressure, HR, and their variability. At 5 wk of age, LH rats exhibited a higher BP than LN and LL controls, which, at 21 wk of age, was associated with significant bradycardia and a greater variability in DBP and HR. LL rats had a MAP similar to LN, which confirms that both strains are, in terms of BP, valid controls for LH animals. The baroreflex sensitivity measured after phenylephrine injections increased with age more markedly in LN and LL than in LH rats, whereas in the latter, it was significantly lower at the age of 9 and 21 wk. When measured after nitroglycerin injections, the baroreflex sensitivity was higher and more stable than that observed after phenylephrine administration. In addition, the baroreflex sensitivity in the different strains was inversely related to the level and the variability of DBP but not of HR.

Aging↗
PubMed1985

Computer analysis of cardiovascular activity in conscious unrestrained hypertensive rats of the Lyon strain.

A new computerized technique was developed for the continuous analysis of intra arterially recorded blood pressure (BP) curve in freely moving rats during long periods of time. For each cardiac cycle 5 parameters were calculated on-line and stored. Off-line processing allowed graphical display and statistical analysis. This technique demonstrated that 21 week-old genetically hypertensive rats from the Lyon strain (LH) exhibited higher and more variable BP and dp/dt max. with a lower heart rate than normotensive (LN) and low blood pressure (LL) controls. LL rats differed from LN by a slightly higher systolic and a lower diastolic BP.

Animals↗
PubMed1984

[Computerized analysis of cardiovascular activity in the conscious unrestrained rat. Application to the study of a new antihypertensive agent].

A more precise knowledge of cardiovascular activity in rats needs its direct recording for long periods of time, in conscious unrestrained animals. A system has been developed, which allows direct recording of blood pressure (BP) in freely moving rats, by means of a floating catheter chronically inserted in the abdominal aorta, connected to a rotating swivel, and then to a pressure transducer. A mini-computer performs on-line processing of BP curves, and stores the values of 5 cardiovascular parameters on hard disk: systolic, diastolic and mean arterial pressures, heart rate and dp/dt max. Off line processing allows graphic and statistical analysis of the data. Simultaneously recording from two rats is very useful in pharmacology because a treated animal and a control one are studied at the same time and in the same conditions. This methodology was used to evaluate the effects of a chronic treatment (2 mg/kg, ip, during 8 days) and of single injections (0.5 and 3 mg/kg, iv) of a new antihypertensive substance, CM 40441a, in 15 W old males SHR.

Adrenergic beta-Antagonists↗