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Biomedical subjects

D F Roberts

Publications and source records attributed to D F Roberts.

At least 109 records · Page 6Linked to original sources
PubMed1981

Antinuclear antibodies and histocompatibility antigens in patients on long-term lithium therapy.

A survey of antinuclear factor, histocompatibility antigens, red blood cell groups and red blood cell isoenzyme variants is reported in 54 patients on long-term lithium therapy. Eleven patients with detectable antinuclear factor could not be distinguished from 43 patients without antinuclear factor using age, sex, diagnosis, previous medication, time on lithium or usual dose of lithium. The presence of antinuclear factor was not associated with any particular genetic marker.

Adult↗
PubMed1981

A genetic study of some Gujarat populations.

A study of gene frequencies at 24 loci and their phenotypes in four castes of Gujarat indicates their general alignment with other populations of western India. There is distinct genetic heterogeneity among them, which appears to be maintained by an endogamous breeding structure. The presence of some marker alleles suggests appreciable African influence in at least one of the castes, but other explanations are possible.

Blood Proteins↗
PubMed1980

Genetic studies among Kanet and Koli of Kinnar district in Himachal Pradesh, India.

Data are presented on serological and electrophoretic variants of 18 systems of red cells in 228 individuals belonging to a scheduled tribe (Kanet) and a scheduled caste (Koli) of Kinnar district in Himachal Pradesh, India. Differences in gene frequencies clearly indicate biological distinction in the local population. The possible cause of this genetic heterogeneity is discussed.

Asian People↗
PubMed1980

Serum protein levels in Iraq.

Since some serum protein levels in Iraq appear to differ from those accepted for European populations, normal standards for Iraq adults were sought. The sample comprised 1,031 subjects who were examined for the following: IgG, M, A and E; the components C3, C4 and C3 proactivator of complement; alpha 2 globulin, albumin and total protein. The mean levels show some differences from those in European sera. Differences occur between various peoples and regions of Iraq, and reasons for these are suggested.

Adult↗
PubMed1980

HLA antigens and thyroid autoantibodies in patients with Graves' disease and their first degree relatives.

Patients with Graves' disease (n = 105) had an increased frequency of HLA-B8 (40%) and a reduced frequency of HLA-B12 (24.8%) when compared with random controls (n = 117; 24.8% and 40.2% respectively). Comparison of patients with their first degree relatives (n = 118) shows the frequency deviations in these antigens to be characteristic of the families from which patients with Graves' disease are drawn, rather than of the disease itself. The haplotypes, identified in eight-six patients and 113 relatives, indicate that the excess of HLA-B8 in patients and their relatives is primarily due to the halpotype 1-8. The relative risk for an HLA-B8 individual of developing Graves' disease is 2.02, whilst the relative risk for an individual of haplotype 1-8 is 4.23. No significant associations were found between the incidence of any HLA antigen or combination thereof and the presence or absence of thyroglobulin and thyroid microsomal antibodies, or antibodies which interact with the TSH receptor.

Autoantibodies↗
PubMed1980

Coeliac disease and HLA: a family study.

In a family study of coeliac disease, HLA types in fifty-three patients and their relatives were examined. There are no differences in HLA frequencies between child and adult patients. Comparison with a random series of normal controls shows increased frequencies in patients of HLA-A1 and B8, while the family material shows that there is also an excess of haplotype 1-8. The excess of homozygotes is thought not to be a factor in the aetiology. Intrafamilial analysis shows that only B8 is significantly associated with the disorder. It is argued that the HLA association does not indicate a 'coeliac gene' but that the B8 allele is a major gene in a polygenic system affecting the disorder.

Adult↗
PubMed1980

Origin of the additional chromosome in Down's syndrome: a study of 20 families.

In 20 families with a Down's syndrome child, heteromorphism of chromosome 21 was sought in the parents and proband. Information on the meiotic division and the parent of origin was given in 16 families, the majority of errors being maternal in origin, predominantly at meiosis I, though the paternal contribution is also appreciable. Probabilities of parental and meiotic division origin are calculated.

Cells, Cultured↗
PubMed1980

Frequencies of Gm and Km allotypes in the population of Singapore, Sri Lanka and Punjabis in North India.

Serum samples from Sinhalese subjects, from Punjab and from Singapore have been studied. The Gm phenotypes found are very numerous and we can observe some similarities concerning the Gm gene frequencies between the Singapore Indians with the Indians of North India, and with the Sinhalese. In contrast, Gm gene frequencies found among Chinese and Malays from Singapore are quite different from those found among Indians of Singapore. Our results here are very similar to those obtained in Malaya studies.

China↗
PubMed1980

Kinship structure and heterozygosity on Tristan da Cunha.

Although there are many factors influencing the genotype proportions in a small population [1], a heterozygote excess, caused by avoidance of incestuous matings, will often be the expected observation. In the population of the small South-Atlantic islands of Tristan da Cunha, such an excess if observed [2], and we have investigated its origin, partitioning the population by sex and by generation. Although for such a small population the test for random pairing of genes [3, 4] is not sufficiently powerful to produce significant results, the pattern of homozygote deficiency is suggestive of avoidance of close matings. We have also investigated the effect of current nuclear family structure and family-size distribution.

Adolescent↗