Search PubMed⌕ Search

Biomedical subjects

D F Magee

Publications and source records attributed to D F Magee.

At least 91 records · Page 5Linked to original sources
PubMed1968

The effects of antral acidification on the gastric secretion stimulated by endogenous and exogenous gastrin.

1. In conscious dogs with Heidenhain fundic pouches and denervated antral pouches control dose-response curves to gastrin pentapeptide or methacholine were constructed, both when the antral pouch was empty and when it was stimulated with ACh (0.5 g/100 ml.) in citrate buffer adjusted to pH 5.5 or 1.5.2. When the antral pouches were irrigated with ACh (0.5 g/100 ml.) at pH 1.5 the acid outputs from the Heidenhain pouch in response to graded doses of gastrin pentapeptide or methacholine were significantly less at each dose level than those obtained with ACh at pH 5.5.3. The acid outputs from the Heidenhain pouch in response to either pentapeptide or methacholine with or without antral irrigation with ACh at pH 1.5 were approximately equal. Therefore the difference between the dose-response curves obtained by stimulation with ACh at pH 5.5 and those obtained by stimulation with ACh at pH 1.5 represents gastrin release rather than release of an inhibitory hormone.4. The pepsin outputs from the Heidenhain pouch during antral irrigation with ACh at pH 1.5 were significantly less than those obtained with ACh at pH 5.5 at each dose of methacholine.5. The maximal pepsin output was significantly greater in response to methacholine than to gastrin pentapeptide.6. Gastrin pentapeptide was not a significant stimulant of pepsin secretion from the Heidenhain pouch.7. The intestinal phase of parietal secretion was not inhibited by bathing the separated antrum with acid.

Acetylcholine↗
PubMed1967

The inhibition of induced motor activity in transplanted fundic pouches.

1. An increase in motor activity of transplanted fundic pouches can be produced repeatedly by an alkaline buffer solution in the duodenum.2. The response can be abolished by small doses of a cholecystokinin-pancreozymin extract.3. The secretagogues, olive oil and peptone will inhibit the response when introduced into the duodenum.4. Acetylcholine in the duodenum will also inhibit the effect.5. Hydrochloric acid will inhibit the motor activity produced by alkaline buffer in the duodenum and also resting activity of the pouches.

Acetylcholine↗