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Biomedical subjects

D F Larkin

Publications and source records attributed to D F Larkin.

46 records · Page 3Linked to original sources
PubMed1990

Experimental Acanthamoeba keratitis: I. Preliminary findings.

Experimental Acanthamoeba keratitis was induced in Wistar rats by intrastromal inoculation of Acanthamoeba polyphaga cysts. Keratitis developed in all corneas injected and was characterised by a diffuse granular opacity. The animals were examined for 70 days and a gradual reduction of keratitis was observed. Pathological sections showed liquefactive stromal necrosis and Acanthamoeba localised in deep stroma persisting to 70 days. A brisk inflammatory infiltrate of neutrophils and macrophages was seen in the early days of infection. Severity of keratitis was found to correlate with inflammatory activity in pathological sections. The uses of an animal model of Acanthamoeba keratitis are described.

Acanthamoeba Keratitis↗
PubMed1988

Orbital fibrous histiocytoma in an infant.

A rare case of fibrous histiocytoma in an infant is described. The tumour appeared to arise in the medial orbit, invading the ethmoid and maxillary sinuses. Surgical and medical management, and the subsequent clinical course in a 11 year follow-up period are described. Histogenesis of this primary mesenchymal tumour is discussed.

Child↗
PubMed1988

Yersinia-induced uveitis in Ireland.

A prospective study was undertaken on 54 patients with an apparently idiopathic first attack of acute anterior uveitis. Blood samples were assayed for antibodies to Yersinia enterocolitica and Yersinia pseudotuberculosis, and tested for HLA type. Thirteen patients were found to have serological evidence of recent yersinia infection, eight with Y. enterocolitica and five with Y. pseudotuberculosis. The clinical course of uveitis did not differ from that typically found in HLA-B27 positive patients. Five patients were observed to develop non-ocular inflammation at a variable interval. The means by which eye inflammation follows yersinia infection is discussed in the light of recent theories on pathogenesis of HLA-B27 associated diseases.

Adult↗
PubMed1988

Developmental glaucoma in oculocutaneous albinism.

A case of oculocutaneous albinism is described in which bilateral Axenfeld's anomaly co-exists. Progressive elevation of intraocular pressure required treatment and this complication has not been reported. Different hypotheses regarding the co-existence of these conditions are reviewed.

Albinism↗
PubMed1987

Management of intraocular pressure during cardiopulmonary bypass.

Intraocular pressure was measured in two groups of patients undergoing cardiopulmonary bypass surgery. A control group received mannitol at the start of bypass in accordance with standard practice; pressure was found to rise by 6.4 mmHg. In a second group of patients mannitol was administered 30 min prior to bypass; pressure elevation of 2.4 mmHg was found. These findings are discussed in relation to other clinical observations during bypass and to ocular morbidity complicating bypass surgery.

Cardiopulmonary Bypass↗
PubMed1987

Intraocular pressure during cardiopulmonary bypass.

Intraocular pressure was measured in 24 patients undergoing elective cardiopulmonary bypass surgery. There was a rapid rise when the bypass circulation began, and this was maintained for about 30 minutes. A simultaneous drop in arterial perfusion pressure and packed cell volume occurred. We suggest that marked haemodilution is responsible for this effect, through increased ocular blood flow and low colloidal osmotic pressure. The possible aetiological significance in relation to ischaemic optic neuropathy complicating cardiopulmonary bypass is discussed.

Adult↗
PubMed1987

Ischaemic optic neuropathy complicating cardiopulmonary bypass.

Bilateral anterior ischaemic optic neuropathy occurred in two patients undergoing cardiopulmonary bypass grafting. The causes may have been vasoconstriction of the posterior ciliary arteries by increased circulating angiotensin and diminished ciliary blood flow in the setting of systemic hypotension and elevated intraocular pressure.

Cardiopulmonary Bypass↗
PubMed1986

Sinus histiocytosis with massive lymphadenopathy simulating subacute thyroiditis.

A white woman who had sinus histiocytosis with massive lymphoadenopathy (SHML) presented with a painful goiter and tender cervical lymph nodes. She had biochemical evidence of hypothyroidism but remained clinically euthyroid. Histologic examination confirmed SHML in the thyroid and cervical lymph nodes. The disease remitted spontaneously.

Adult↗