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Biomedical subjects

D F King

Publications and source records attributed to D F King.

At least 55 records · Page 3Linked to original sources
PubMed1980

Generalized morphea with peripheral eosinophilia, fasciitis and myositis.

The distinctions between eosinophilic fascitis (Shulman's syndrome) and scleroderma may sometimes be unclear. We describe a patient with generalized morphea who also had peripheral blood eosinophilia, fibrosis and inflammation of fascia, and hyper-globulinemia, features usually attributed to Shulman's syndrome. The latter diagnosis should be restricted to those patients whose history, clinical and laboratory findings, and response to therapy closely resemble Shulman's original description. Scleroderma and eosinophilic fasciitis may represent slightly differing aspects of the same disease spectrum, with a similar immunologic pathogenesis.

Adrenal Cortex Hormones↗
PubMed1980

Intraepithelial elastic fibers and intracytoplasmic glycogen: diagnostic aids in differentiating keratoacanthoma from squamous cell carcinoma.

A significant statistical difference was found between the incidence of intraepithelial elastic fibers in keratoacanthoma and squamous cell carcinoma arising in actinic keratosis (P < 0.001). There was no significant difference when keratoacanthoma was compared to adenoid squamous cell carcinoma (P = 0.13) and de novo squamous cell carcinoma (P = 0.73). However, in keratoacanthoma intraepithelial elastic fibers were found in areas of pseudoepitheliomatous hyperplasia and in the central keratin plug, as well as in areas of infiltrating, peripheral keratinocytes. In adenoid squamous cell carcinoma and de novo squamous cell carcinoma, the intraepithelial elastic fibers were found only in areas of atypical epithelial cells at the margin of the neoplasm. Intracytoplasmic glycogen was found to be statistically more abundant in keratoacanthoma than in squamous cell carcinoma arising in actinic keratosis (P < 0.001), adenoid squamous cell carcinoma (P < 0.001), and in de novo squamous cell carcinoma (P < 0.001)

Carcinoma, Squamous Cell↗
PubMed1980

Immunoperoxidase staining of cytoplasmic immunoglobulins. A diagnostic aid in distinguishing cutaneous reactive lymphoid hyperplasia from malignant lymphoma.

A method for staining cytoplasmic immunoglobulins utilizing an immunoperoxidase technic on paraffin-embedded tissue was used to examine two cutaneous lesions. On routine hematoxylin-eosin staining, one lesion exhibited what appeared to be a mixed population of mature cell types and was therefore interpreted as reactive lymphoid hyperplasia, whereas the other lesion showed a uniform population of immature cells and was interpreted as a malignant lymphoma. Immunoperoxidase staining supported these interpretations since the reactive lesion showed polyclonal IgG lambda and kappa staining, and the malignant lymphoma monoclonal staining with IgG lambda. In selected material, immunoperoxidase staining can distinguish a truly mixed population of cell types (probably benign) from a monoclonal population of cells exhibiting either uniform or mixed morphologic configurations associated with B lymphocyte transformation (probably malignant).

Aged↗
PubMed1979

Fibrous hamartoma of infancy.

Fibrous hamartoma of infancy is a type of juvenile fibromatosis which is either present at birth or develops before two years of age. If one is not familiar with this histological pattern, it could be mistaken for a malignant mesenchymal neoplasm. We describe the characteristic clinical and microscopic features.

Diagnosis, Differential↗
PubMed1979

Granular-cell tumors of the vulva: a report of three cases.

Three black women were found to have granular-cell tumors on the vulva; in one, there were several additionally in other cutaneous sites. Although this benign neoplasm is uncommon on the vulva, it should be considered in the differential diagnosis of nodular lesions on the vulva. Granular-cell tumors in multiplicity occur frequently and are not a sign of metastatic disease. This lesion has predilection for blacks. Pseudocarcinomatous hyperplasia occurs typically in overlying squamous epithelium and may be misinterpreted as squamous-cell carcinoma.

Adult↗