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Biomedical subjects

D F Kelly

Publications and source records attributed to D F Kelly.

At least 127 records · Page 7Linked to original sources
PubMed1979

Argon laser photocoagulation in the dog stomach.

Laser photocoagulation is one of a number of methods currently under investigation for the endoscopic treatment of gastrointestinal haemorrhage. The Argon ion and Neodymium Yttrium Aluminium Garnet (Nd YAG) lasers are theoretically suitable as the beam from each may be transmitted via a flexible fibre. Argon laser photocoagulation has been shown to be effective and we have elucidated which factors determine its safety and efficacy. Studies on normal canine gastric mucosa showed that the depth of tissue damage depended chiefly on the total incident laser energy on any one spot, and that below 50 J the risk of perforation was extremely low. The energy density was much less important. The haemostatic effect depended more on the laser power. In artificial bleeding gastric ulcers in heparinised dogs the most effective level was 7--9 W, at which 22 out of 23 ulcers (96%) stopped bleeding completely, compared with one out of 12 controls. Photocoagulation was achieved in these cases with energies well within the safe limits. The procedure was effective endoscopically, and these results justify early clinical studies in man.

Absorption↗
PubMed1979

A lymphomatoid granulomatosis of the lungs in young dogs.

Clinical signs in three young dogs with primary lung neoplasms included cough, weight loss and anorexia. Chest radiographs taken in the terminal stages of the disease showed nodular and diffuse consolidation of the lungs typical of primary neoplasms. Macroscopically the lungs were infiltrated by firm, pale tissue; similar tissue replaced the enlarged bronchial lymph nodes. In two dogs similar deposits were found also in the liver and spleen. The infiltrates were composed of atypical, polymorphous lymphoreticular cells. Invasion of pulmonary blood vessels and of bronchi and bronchioles was striking. The lesions closely resembled those of lymphomatoid granulomatosis, a rare human disease of unknown cause.

Animals↗
PubMed1979

Histology of salivary gland infarction in the dog.

Salivary gland infarction was found in two adult dogs. The main changes were ischaemic necrosis, capsular fibrosis and regenerative hyperplasia of surviving ductal epithelium. Necrosis of arterial tunica media and thrombosis were found only in the infarcted parts of the salivary glands. The lesions appeared to be confined to the salivary glands; no cause of the infarction was found.

Animals↗
PubMed1979

Megaloesophagus and associated gastric heterotopia in the cat.

Two young adult male Siamese cats had heterotopic gastric mucosa in the dilated and inflamed oesophagi. Normally differentiated gastric mucosal glands were present and there was severe ulceration in one cat. It is uncertain whether the gastric heterotopia was a reparative change after oesophagitis or whether it represented a coincidental anatomical anomaly.

Animals↗
PubMed1977

Acute respiratory distress in the dog associated with paraquat poisoning.

An acute respiratory distress syndrome in 10 adult dogs was usually preceded by vomiting, anorexia and lethargy followed, after a short interval, by dyspnoea. The dyspnoea became increasingly severe, despite oxygen therapy, and cyanotic respiratory failure ensued. All 10 dogs died or were killed after illnesses lasting between one and eight days. Necropsies revealed pulmonary congestion, oedema, collapse and haemorrhage with loss of alveolar epithelial cells. Early alveolar fibrosis was also found. Paraquat was identified in post mortem samples from four of the 10 dogs.

Animals↗
PubMed1977

Experimental infection of rabbits with the virus of infectious bovine rhinotracheitis.

Adult and newborn rabbits were infected with the LA strain of infectious bovine rhinotracheitis virus. Adult rabbits developed only mild, self-limiting conjunctivitis, but had microscopic inflammatory foci in the liver and adrenal glands. Newborn rabbits developed a severe, sometimes fatal, generalized infection with focal and diffuse necrosis of the liver and adrenal glands.

Adrenal Gland Diseases↗
PubMed1976

Spongy degeneration of the central nervous system in kittens.

The paper describes the clinical and morphological features of a congenital neurological disease affecting two in-bred litter-mate kittens. The principal neurological features were ataxia and dysmetria. In one of the kittens light microscopy revealed widespread vacuolation of white and grey matter of the brain and spinal cord. Electron microscopy revealved intra-myelinic vacuolation and some expansion of the extracellular space. Neuronal, axonal and glial changes were not seen, nor was there evidence of myelin breakdown. The entity is compared with congenital brain oedema of calves and spongy degeneration of the CNS in man.

Animals↗
PubMed1976

Epidermoid cyst of the brain in the horse.

An aged Connemara mare had a neurological illness lasting 3 weeks and characterised by episodes of dullness, head-pressing, staggering gait and hyperexcitability. The signs recurred at intervals of 3 to 4 days, with intervening periods of apparent normality. Post-mortem examination revealed an epidermoid cyst on the dorsal surface of the occipital lobe of the left cerebral hemisphere. The cyst was lined by stratified squamous epithelium and contained desquamated keratinised material and blood. The lesion is considered to be a congenital malformation which enlarges and produces space-occupying signs.

Animals↗
PubMed1976

Renal carcinoma in the dog.

Thirty-three cases of canine renal carcinoma reported between 1907 and 1972 are reviewed, and clinical and pathological features of nine other cases seen in Bristol between 1966 and 1975 are described. Clinical features frequently include nonspecific signs of anorexia and weight loss. The age range of affected dogs varies from 3 to 15 years, with a mean of 7.1 years. Male dogs appear to be affected more frequently than females, but there is no breed predilection. The clinical behaviour of canine renal carcinoma is variable, with 4 years the longest survival time after nephrectomy. The primary tumours characteristically are large and unilateral and occupy most of one pole of a kidney. Metastatic spread can involve a wide range of organs, the commonest being lymph nodes and lung. Solid, tubular and papillary patterns are common. Clear cell carcinoma is uncommon.

Animals↗