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Biomedical subjects

D F Hawkins

Publications and source records attributed to D F Hawkins.

At least 37 records · Page 2Linked to original sources
PubMed1986

Antibacterial activity in human amniotic fluid: dependence on divalent cations.

Antibacterial activity, tested against Bacillus subtilis, was present in all 34 samples of human amniotic fluid collected between 37 and 41 weeks gestation. High-molecular-weight (beta-lysin) antibacterial activity was reduced after treatment with ethylene diamine tetra-acetic acid (EDTA), but not after treatment with 1, 10-phenanthroline or diphenylthiocarbazone. The activity was restored following incubation with magnesium, calcium, or zinc. Low-molecular-weight antibacterial activity (less than 1000 daltons) in acid-alcohol extracts was reduced after treatment with dithizone, but not after treatment with EDTA or 1, 10 phenanthroline. Activity was restored after treatment with manganese, cobalt or zinc. High-molecular-weight (beta-lysin) activity was therefore biochemically similar to serum beta-lysin but biochemically different from the low-molecular-weight antibacterial component of amniotic fluid.

Adult↗
PubMed1985

Renal clearance of amino acids in pregnancy complicated by preeclampsia.

Renal clearance of most amino acids was increased in the third trimester of pregnancy. The greatest change was with glycine, where clearance increased thirteen-fold and the plasma level decreased. No difference in renal clearance of amino acids was demonstrated in four patients with proteinuric hypertension when compared with that in normal pregnancy. Progesterone, given to non-pregnant women, caused a fall in mean plasma glycine. This was associated with increased renal clearance in 2 out of 3 women, and indicates that progesterone may contribute to the increased renal excretion of some amino acids in pregnancy, probably acting selectively on tubular reabsorption.

Adolescent↗
PubMed1984

Antibacterial activity in human amniotic fluid: relationship to zinc and phosphate.

Antibacterial activity, tested with B. subtilis, was present in all 44 human amniotic fluids at between 36 and 42 weeks of pregnancy and was unrelated to gestational age within these limits, or to maternal age or parity. High-molecular-weight (beta-lysin) activity, present in all samples, was directly related to concentration of bound zinc, but not to that of free zinc. Low-molecular-weight antibacterial activity (less than 1000 Daltons) was only present in nine specimens, but sub-threshold concentrations were demonstrable by concentrating the ultrafiltrates in more than half of the remaining specimens. Low-molecular-weight activity in the ultrafiltrates was directly related to the concentration of bound zinc in the original amniotic fluid. Neither high- nor low-molecular-weight antibacterial activities were associated with amniotic fluid phosphate levels.

Adult↗
PubMed1984

Caffeine, theophylline and theobromine in pregnancy.

Dietary surveys estimated the caffeine intake of pregnant women in London to average 1.4 mmol (270 mg) with a range of 0 to 6.0 mmol (0-1160 mg)/day. The average plasma caffeine was 6.5 (SD 2.8-14.8), plasma theophylline 2.9 (SD 1.3-6.7), plasma theobromine 2.1 (SD 0.9-4.9) mumol/l. The results of the dietary surveys showed a fair correlation (r = 0.59; p less than 0.01) with plasma caffeine levels, but the surveys are best regarded as a basis for counseling rather than an accurate estimate of intake.

Caffeine↗
PubMed1983

Scanning electron microscope study of Candida albicans invasion of cultured human cervical epithelial cells.

The invasion of monolayer cultures of epithelial cells from the human uterine cervix by clinical isolates of Candida albicans was observed. Blastospores settle on the epithelial cells and produce germ tubes within 2 h. Hyphae penetrate the epithelial cell walls and destroy the cells, weaving in and out of the cytoplasm. No phagocytosis of yeast cells by epithelial cells was seen.

Candida albicans↗
PubMed1983

Drugs in pregnancy.

Explore the source record for details and available documents.

Alcohol Drinking↗
PubMed1977

Hepatitis B antigen-positive obstetric patients.

In a period of six years (1971--77) 9400 sera taken at booking from antenatal patients were examined for hepatitis B antigen (HBsAg), and 40 patients were positive. These 40 patients had 45 pregnancies and were treated with special precautions so far as venepuncture and the management of delivery were concerned. No member of the hospital staff dealing with the patients developed hepatitis B. All infants born to these mothers were normal, two infants were HBsAg-positive at 7 months and 2 years, but are clinically well. No obstetric problems attributable to the HBsAg-positive state were encountered.

Adolescent↗