Search PubMed⌕ Search

Biomedical subjects

D F Cohn

Publications and source records attributed to D F Cohn.

At least 37 records · Page 2Linked to original sources
PubMed1985

Computed tomographic demonstration of brain changes in incontinentia pigmenti.

Incontinentia pigmenti is a rare condition, which may involve the central nervous system. Computed tomographic (CT) examination can supply important information about the dynamics and pathologic nature of this poorly understood syndrome. Two patients suffering from incontinentia pigmenti were examined by CT because of central nervous system symptoms. Large low-density areas in the brain were demonstrated in the CT examination of the first patient a few days after birth, suggesting a local edema. Diffuse brain atrophy was found two years later. Brain atrophy was also found in the second patient in a CT examination done at the age of 11 years.

Atrophy↗
PubMed1983

Intoxication by the chickling pea (Lathyrus sativus): nervous system and skeletal findings.

Two hundred patients with chronic neurolathyrism were examined 25-35 years after the appearance of signs and symptoms of intoxication of the chickling pea. Their daily food intake, in a German forced labor camp during World War II, consisted of 400 g Lathyrus sativus peas cooked in water plus 200 g bread baked of barley and straw. Apart from the classic signs of neurolathyrism, i.e., a spastic paraparesis, in five cases, the skeletal findings observed were similar to experimental osteolathyrism. There was an absence of ossification centers of the iliac creasts, ischial tuberosities and vertebrae; and bowing with thickening of the femoral shaft also occurred. These bony changes in human lathyrism have not been described before.

Adolescent↗
PubMed1982

Is there a climatic influence on the blood level of anticonvulsive drugs?

The diphenylhydantoin concentration in ten treated epileptics was determined during a period of two years in Tel-Aviv, Israel where subtropical climate prevails. The data collected showed a significant decrease at the end of Summer and a significant increase at the end of Winter. Since diphenylhydantoin is excreted in the sweat and sweating is excessive during the Summer months in the area where the study was undertaken, it is suggested that the increase of perspiration is responsible for the drop of diphenylhydantoin serum concentration. No other seasonal biological rhythms are known to us which could be incriminating.

Climate↗
PubMed1982

The effect of anticonvulsant drugs on the development of male rats and their fertility.

Albino male rats were injected with diphenylhydantoin, carbamazepine, valproic acid or clonazepam for three months immediately after weaning. Following the treatment the fertility of the rats was tested by caging them with proestrus females and recording impregnations. The males were decapitated and their sex organs weighed. Epididymal sperm content and motility rate were recorded. A decrease in the prostate weight was found in the valproic acid and the carbamazepine treated rats. Epididymal weights were found decreased only in the valproic acid treated rats. These rats had diminished sperm content and sperm motility and their fertility was decreased. Carbamazepine treated rats had a lowered epididymal sperm content which did not affect their fertility.

Animals↗
PubMed1982

[The problem of postmyelography headaches].

Sixty-eight patients were studied and observed before and after a myelography. Thirty-five patients complained of headache as soon as contrast material drops penetrated the great cystern. Twenty-two patients in whom the contrast material reached the region of the sella turcica complained immediately about headache as soon as the material was seen there. Twelve patients complained about headache for six months and more following the myelography. These patients showed remnants of contrast material in the hypophyseal region. The cause of these headaches possibly is the irritation of the greater blood vessels, such as the carotid and basilar arteries. To avoid massive penetration of contrast material into the skull, it is suggested that lateral x-ray films be performed while the patient lies on his side and not prone.

Adult↗
PubMed1981

[Radiographic isodense subdural hematomas in computerized tomography].

Report on three patients in whom computer tomography (CT) revealed an isodense subdural hematoma. One patient had a CT scan 24 hours, the other 3 weeks and the third 3 months after the appearance of clinical symptoms. It is therefore impossible to predict at what stage a subdural hematoma will appear isodense in the CT. The criteria for identification of isodense subdural hematoma are reviewed.

Aged↗
PubMed1981

Falx myeloid metaplasia in myelofibrosis. A CT demonstration.

Myelofibrosis, known also as myelosclerosis, tends to form myeloid metaplasia in all organs of the body. The nervous system and intracranial structures are rarely involved. A case of myeloid metaplasia in the falx, which caused headache and papilledema, was observed gaining in size on repeated CT scans.

Adult↗
PubMed1981

Human neurolathyrism, a follow-up study of 200 patients. Part I: Clinical investigation.

Two hundred patients with chronic neurolathyrism were clinically examined, 25 to 35 years after exposure to the lathyrus sativus pea. All the patients were prisoners in a labour camp under similar nutritional and physical conditions at the outbreak of the syndome. The main symptoms were spastic paraparesis and a neurogenic bladder, both of varying degree. In addition lower motor neuron involvement with muscular atrophies was noticed in 14 cases and simulated amyotrophic lateral sclerosis. A lathyric sensory neuropathy was found in 12 patients. No cranial lesions or psychiatric disorders were found. Laboratory tests including 5 CSF specimens were normal. HLA typing was unremarkable. Our overall impression was that chronic neurolathyrism in the long run shows a gradually slow progressive course.

Adult↗
PubMed1981

Human neurolathyrism, a follow-up study. Part II: Special investigations.

Special investigations were undertaken in the group of patients suffering from chronic neurolathyrism as described in part one of our work. X-ray films of the skeleton were taken of 45 patients. Pathologic findings similar to experimental osteolathyrism were revealed in 5 patients. These observations have not been described before. Sural nerve biopsies were taken from three patients with lathyric sensory neuropathy. Electron microscopy revealed mainly thick myelin sheaths which extended into the axonal regions. The picture is similar to the "tomaculous" neuropathy of Bradley. The lower motor neuron was involved in a few cases, manifested by delayed nerve conduction time and muscular atrophies.

Adolescent↗