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Biomedical subjects

D Evans

Publications and source records attributed to D Evans.

At least 343 records · Page 19Linked to original sources
PubMed1978

Limitations of a single extra-amniotic injection of prostaglandins in viscous gel to induce midtrimester abortion.

A dose-response study using PGE2 in a viscous gel has been undertaken for induction of midtrimester abortion. A direct relationship was found between the time to abortion and the dose administered. However, even using PGE2 3.5 mg induced uterine activity was noticed to subside in a significant number of women after approximately 6 h. For routine management it is suggested that PGE2 3.5 mg be injected and followed by repeat doses 6 h later with removal of the injecting catheter on each occasion.

Abortion, Induced↗
PubMed1977

Blood pressure effects of lower abdominal aortic surgery with particular reference to the use of morphine and droperidol in modifying the responses.

Hypertensive responses during operations on the abdominal aorta are common. We have shown that hypertensive changes occur before cross-clamping of the aorta. We have also shown that droperidol modifies the hypertensive changes in operations on the lower aorta. Although further studies are required, our preliminary results show a higher rise of serum epinephrine and norepinephrine levels in one patient receiving morphine, as compared to one patient receiving the same dose per unit body weight of morphine plus droperidol. With maintenance of adequate pre-operative hydration and intra-operative fluid and blood replacement, declamping hypotension was transient in both groups of our patients.

Adult↗
PubMed1977

Synthesis and antiinflammatory activity of some 2-aryl-6-benzoxazoleacetic acid derivatives.

Various approaches to the synthesis of 2-aryl-6-substituted benzoxazoles are described. The products, which included the 6-methyl derivative 4a, ethylamines 10 and 19, ethanols 12 and 14, the acetic and alpha-methylacetic acids 9 and 16a--f, and the acetic ester 11, were screened for antiinflammatory activity on the carrageenan-induced rat paw edema test. Some of the compounds possessed activity superior to that of phenylbutazone and of the same order as that of benoxaprofen.

Adrenalectomy↗
PubMed1976

Simulated aircraft disaster instructional exercise at Baltimore-Washington International Airport.

A major, simulated aircraft disaster exercise was held in September of 1974 at the Baltimore-Washington International Airport in Maryland. The significant aspects of community involvement and specialized airport emergency planning were tested during this simulation. This paper presents an evaluation of the experience of the various elements in this exercise. The critical matter of having a system of runners to substitute for a failure within the mobile command post is stressed. Also, the importance of adequate telephone facilities for communication with the fire/rescue stations and community hospitals is highlighted. Many other small and seemingly unimportant items are found to be of considerable significance during the handling of disasters. A strong case is made for periodic disaster simulations to maintain an efficient broadly-based apparatus for handling such disasters, should they occur.

Aviation↗
PubMed1975

Pathogenesis of gangrene following intra-arterial injection of drugs: a new hypothesis.

We have demonstrated the toxicity of diazepam and the safety of ketamine hydrochloride following intra-arterial injection in an anaesthetized animal model. The pathogenesis of gangrene following intra-arterial injection of drugs is unclear. Clinical reports and this experiment suggest that it only follows injection of highly membrane-soluble drugs. Early swelling and disruption of capillary endothelial cells were demonstrated after intra-arterial injection of diazepam and thiopentone. We believe that a theory of pathogenesis based on this finding is consistent not only with our experimental findings, but with known in vitro effects of membrane soluble drugs on cell membranes and the clinical features following intra-arterial injections in both human subjects and in animals.

Animals↗
PubMed1975

2-aryl-5-benzoxazolealkanoic acid derivatives with notable antiinflammatory activity.

The synthesis and antiinflammatory activity of 5-substituted 2-arylbenzoxazoles are described. Initial screening on carrageenin-induced rat paw edema showed that alpha-methylacetic substitution in the 5 position was preferable to substitutions with the equivalent esters, amides, alcohols, amines or tetrazoles. Halogen substitution in the aryl ring led to the most active compounds which were 2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid (14) and 2-(4-fluorophenyl)-alpha-methyl-5-benzoxazoleacetic acid (29). These compounds were three to five times more active than phenylbutazone as assessed from ED30 values determined on rat paw edema 5 hr after single oral doses.

Animals↗
PubMed1975

Calcaneo-valgus deformity.

A discussion of the essential deformity in calcaneo-valgus feet develops a theme originally put forward in 1961 on the relapsed club foot (Evans 1961). Whereas in the normal foot the medial and lateral columns are about equal in length, in talipes equino-varus the lateral column is longer and in calcaneo-valgus shorter than the medial column. The suggestion is that in the treatment of both deformities the length of the columns be made equal. A method is described of treating calcaneo-valgus deformity by inserting cortical bone grafts taken from the tibia to elongate the anterior end of the calcaneus.

Adolescent↗