[Therapy with 25-hydroxycholecalcipherol (25-HCC) in calcium resorption errors during anti-epileptic treatment].
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Biomedical subjects
Publications and source records attributed to D Emrich.
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Quantitative measurement of radiation absorption of an external 125I source does not give information about calcium decrease of the skeletal system in an individual case. Of 50 patients under an age of 40 years who demonstrated osteoporosis by roentgenography, only 19 patients had absorption coefficients of the spongiosa in a pathological range. However there was a significant decrease of the absorption coefficients in two patients collectives with decreased calcium bone diseases. The insufficient diagnostic information in an individual patient is explained by the overlap of absorption values in normals and patients with decreased calcium. This is caused by the difficulties to determine the absorption of the finger and the insufficient discrimination of scattered radiation.
According to Zierler's theoretical deduction time activity curves obtained from different parts of the central circulation after injection of a bolus of radioactivity are dependent on the volume and the flow. We tried to prove this by experiments and checked simultaneously the quality of the method developed by us using a Gamma Camera and a computer. We correlated the peak to peak time from the right to the left ventricle and the mean transit time of the left ventricle with the cardiac index and the enddiastolic volume of the left ventricle in patients with valvular heart disease. For this purpose patients were selected in whom either the cardiac index or the enddiastolic volume of the left ventricle were in the normal range. Under these conditions there was a highly significant correlation between these parameters. Moreover the mean pressure of the pulmonary artery and the mean pulmonary wedge pressure correlated significantly with the peak to peak time from the right ventricle to pulmonary artery. This may be explained by the correlation between the volume of the pulmonary vascular system and its pressures. As expected, there was no correlation between the time parameters from the nuclear medicine method and the enddiastolic pressure of the left ventricle in patients with valvular heart disease. The results are in good agreement with the diagnostic accuracy of the method in recognizing valvular heart disease as well as with the correlation between the hemodynamic stage in valvular heart disease and the change of the time parameters of the time activity curves.
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