Search PubMed⌕ Search

Biomedical subjects

D Elmqvist

Publications and source records attributed to D Elmqvist.

61 records · Page 4Linked to original sources
PubMedDate not supplied

Daytime sleep tendency before and after discontinuation of antiepileptic drugs in preadolescent children with epilepsy.

In 9 preadolescent children treated for epilepsy who had been free from seizures long enough for treatment to be discontinued, daytime vigilance was studied before and after discontinuation of antiepileptic drugs (AEDs). Comparisons were made with healthy controls. Multiple sleep latency test (MSLT), EEG, and a questionnaire were used. As part of the analysis of the MSLT, a new measure, the daily average sleep tendency (DAST), was constructed to overcome the problems with data censoring of the classic MSLT analysis. The patients had significantly (p less than 0.001) higher daytime sleep tendency, even after drug discontinuation, than controls, a result that could neither be attributed to AED treatment nor to recent epileptic seizures or complicated epilepsy.

Anticonvulsants↗
PubMedDate not supplied

Comparison between EEG and observation of rabbit behaviour in evaluation of subarachnoid neurotoxicity of metrizamide.

The non-ionic contrast medium metrizamide (370 mg I/ml) was injected into the cisterna magna of rabbits at 2 dose levels (0.1 ml/kg and 0.5 ml/kg) to investigate whether visually evaluated EEG can detect neurotoxicity at a lower dose level than a method based on observation and ranking of signs of excitation and depression in animal behaviour. Half of the metrizamide injections were made without anaesthesia, whereas the remaining injections were made during a short alphadolon/alphaxolon anaesthesia. EEG and animal behaviour were followed for 24 h after the injection of metrizamide. At the low 'clinical' dose, EEG could not detect statistically significant neurotoxicity, neither in anaesthetized nor in non-anaesthetized rabbits. Observation of animal behaviour, however, could detect statistically significant signs of depression in animals that had been anaesthetized. At the high dose level, both methods could detect significantly more serious symptoms of neurotoxicity than at the low dose level.

Anesthetics↗
PubMedDate not supplied

Nocturnal hypoxaemia and cor pulmonale in severe chronic lung disease.

The relation between daytime and nocturnal hypoxaemia on one hand and right ventricular failure (RVF) and hypertrophy (RVH) on the other was studied in 21 patients with severely reduced ventilatory capacity. RVH was assessed by myocardial scintigraphy, vector cardiography and echocardiography. Seven patients had suffered from acute RVF at least once. They had lower vital capacity and PaO2 and higher PaCO2 than patients without a history of RVF. They also had a more severe nocturnal hypoxaemia. They did not, however, have more severe RVH than patients without a history of RVF. Blood gases during daytime were not related to RVH. Oxygen saturation during sleep had a weak inverse relationship to RVH determined with scintigraphy, but not with the other methods. Nocturnal hypoxaemia was closely related to hypoxaemia and hypercapnia during daytime. A difference between daytime PaO2 and PaCO2 less than 2 kPa could with reasonable accuracy identify patients with nocturnal hypoxaemia.

Aged↗
PubMedDate not supplied

Hemifacial spasm. Nerve block with phenol under electromyographic control.

Seven cases of hemifacial spasm are described. Six were operated upon with intra-osseal exposure of the facial nerve. In all 6 cases transient peripheral facial paresis developed. When the paresis disappeared the patients had a recurrence of the spasms. As an alternative to surgical procedures a method for selective nerve block under E. M. G. control with 3% phenol is described and 5 cases have been treated with this method. Ambulatory treatment with deposition of 3% phenol in the main branch of the facial nerve appears to have an equally good effect to the surgical methods hitherto used. Examination with E. M. G. suggested that the hemifacial spasm is of central origin.

Electromyography↗