Biomedical subjects

D E Waite

Publications and source records attributed to D E Waite.

At least 55 records · Page 3Linked to original sources

PubMed1980

Posttreatment stability and esthetics of orthognathic surgery.

Several procedures were identified as important adjuncts to successful orthognathic results. Among these were the use of laminagraphic X-rays to monitor condyle displacement, condyle resorption and fibrous union problems. Other aspects involve gnathological errors in splint and positioner design, misdiagnosis because of a lack of soft-tissue analysis, differential treatment planning in deciding if surgery is needed, and understanding surgical effects on proportionality of the nose and lip esthetics.

Bone Resorption↗

PubMed1979

Malignant melanotic neuroectodermal tumor of infancy: a clinical, pathologic, ultrastructural and tissue culture study.

The melanotic neuroectodermal tumor of infancy is an uncommon neoplasm typically of early childhood which has a predilection for the head and neck region, particularly the maxilla. Except for one previous example in the literature, this tumor has consistently behaved in a benign fashion. This study documents the clinical course and pathologic findings of a tumor which began in the maxilla of a 4-month-old boy, followed by a local recurrence, metastasis to a cervical lymph node and finally, widespread dissemination and death at 18 months, 24 months and 38 months, respectively. The tumor was initially composed of nests consisting of melanin-containing cells and small dark cells. An elevated vanillylmandelic acid level was recorded during the course of the disease. At autopsy, the tumor in lymph nodes, liver, bone and soft tissues had a monotonous pattern of small dark cells similar to a conventional neuroblastoma. Previous ultrastructural studies indicate that the melanotic neuroectodermal tumor of infancy is composed of melanocytes and neuroblast-like cells. Our case provided the unique opportunity to examine in sequence the ultrastructural and in vitro characteristics of a recurring and eventually metastasizing melanotic neuroectodermal tumor. Although the neuroblast-like cells were initially difficult to identify by electron microscopy, a melanin-producing cell line and a separate nonpigmented cell line were successfully isolated from various tumor explants. Various stages of melanosome development were identified in the pigmented cells from the local recurrences and in vitro. Dibutyryl cAMP accentuated the formation of pigment and dendritic development in the melanocytes and dendrites only in the small nonpigmented cells. Electron dense granules were observed in the cultured smaller cells and also in the lymph node and soft tissue metastases. Tyrosine hydroxylase activity was demonstrated in the neuroblast-like cells. In the final biopsy and autopsy material, only the neuroblast-like cells remained and the tumor resembled a conventional neuroblastoma.

Culture Techniques↗

PubMed1979

Fibrous dysplasia of the jaws. Report of five cases.

A brief review of the literature concerning fibrous dysplasia and fibro-osseous lesions of the jaws is presented. Five cases of fibrous dysplasia are described. The manner of presentation, diagnosis, histologic appearance, and treatment of this disease entity are discussed in light of previously published data. Histologically, two cases showed the "classic" features of woven bone in the fibrous stroma. The remaining three cases showed variable amounts of lamellar bone. The presence of lamellar bone is not considered incompatible with a diagnosis of fibrous dysplasia of the jaw, especially in older patients and in those in whom the lesion is of longer duration.

Adult↗

PubMed1979

Congenital monostotic fibrous dysplasia--a new possibly autosomal recessive disorder.

Two siblings, a 3-month-old white male infant and a 12-day-old female infant, had an anterior mandibular bony lesion that, in both cases, had been present at birth. After evaluation of clinical, physical, radiographic, laboratory, and histologic findings, a diagnosis of congenital monostotic fibrous dysplasia was made. Thorough review of the literature on fibrous dysplasia yielded no similar cases. The two cases presented appear to be the first reported examples of congenital monostotic fibrous dysplasia in siblings. The parents said there was no consanguinity. The possibility of a new autosomal-recessive disorder is likely.

Chromosomes↗

PubMed1978

Surgical correction of macroglossia in Beckwith-Wiedemann syndrome.

Two cases of Beckwith-Wiedemann syndrome have been reported. The children were large at birth and had an umbilical defect and macroglossia. After considering several alternatives, the elliptical (modified Butlin-Handley), U-shaped excision was used in case 1 for the following reasons: symmetry and minimal disturbance of muscle attachment, reduction of thickness without reduction of width, and reduction in length of the tongue. Use of the V-shaped excision proved most advantageous in the second case where length, rather than thickness, was the only problem. It was hoped that partial glossectomy at an early age might help circumvent the attendant sequelae of macroglossia in patients with Beckwith-Wiedemann syndrome.

Abnormalities, Multiple↗

PubMed1978

Movement of the proximal and distal segments after mandibular ramus osteotomies.

Data was collected from 27 patients who were treated with various ramal surgical procedures. Movements of the proximal segment during and after surgery were frequently noted. If the proximal segment was moved from its preoperative position and fixed to the distal segment, occlusal relapse was visible shortly after release of maxillomandibular fixation. Proximal segments displaced during surgery and not fixed to the distal segment frequently returned to their preoperative positions during fixation or assumed positions of biologic equilibrium. In such cases, occlusal relapse was minimal or nonexistent.

Adolescent↗

PubMed1977

Quantitation of blood flow after Le Fort I osteotomy.

Le Fort I maxillary osteotomies were performed on ten macaque monkeys. The particle distribution method (nondiffusible radioactive microspheres) was used to quantitate local blood flow before and after surgery. Significant reduction in blood flow to the osteotomized maxillary segment was noted in those animals (group S) where the descending palatine vessels were transected. Those animals in which the vascular pedicle was intact (group I) showed decreased blood flow to the attached gingiva and alveolar bone, but palatal tissue blood flow was unchanged or increased. The results reinforce the precept of the importance of maintaining an adequate nutrient pedicle when performing orthognathic surgical procedures.

Alveolar Process↗

PubMed1976

Ridge augmentation: an evaluation and follow-up report.

An evaluation was made of results of follow-up studies, ranging from nine months to about 3 1/2 years, of six patients who had mandibular ridge augmentations at the University of Minnesota Hospitals. Clinical observations, patients' subjective feelings, and measurements of vertical loss of the original graft were the main considerations in the studies. Although there was almost continual resorption of the bone grafts after surgery patients were satisfied with the procedure and the current dental function.

Alveolar Process↗

PubMed1975

Central hemangioma of the mandible: intraoral resection and reconstruction.

A review of the literature and report of a case of central hemangioma of the mandible have been presented. This case has merit from the standpoint of the relative rarity of the lesion within the jaws, and the means by which reconstruction was carried out. Most significant in the presentation is a reminded to all maxillofacial surgeons that any osteolytic defect in either jaw can be a central hemangioma. Because of the serious consequences of biopsy or of extraction of teeth, hemangioma must always be considered in the differential diagnosis; proper precautions must be taken in establishment of a final diagnosis before surgical intervention is undertaken.

Angiography↗

PubMed1975