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Biomedical subjects

D E Tee

Publications and source records attributed to D E Tee.

At least 37 records · Page 2Linked to original sources
PubMed1980

Identification of biliary antigens in circulating immune complexes in primary biliary cirrhosis.

The presence of biliary tract antigens in circulating immune complexes from patients with primary biliary cirrhosis (PBC) was investigated. Concentrations of immune complexes in PBC sera, measured by the Raji cell immunoassay, ranged from 58 to greater than 1,000 microgram/ml, but did not correlate with disease activity. Immunofluorescent staining of complexes bound to Raji cells was carried out with guinea-pig antiserum raised against biliary tract antigens. Positive staining reactions were observed with complexes obtained from PBC patients, but not with those obtained from patients with systemic lupus erythematosus or rheumatoid arthritis, indicating that in PBC antigenic components associated with the biliary tract are contained within the complexes.

Antigen-Antibody Complex↗
PubMed1977

Modified Makari skin test in follow-up of bladder-cancer patients.

123 patients who had been treated for carcinoma of the bladder and who were clinically recurrence-free at the time of their initial Makari skin test are being followed-up; 77 were negative and 46 positive. 48 of these patients have been followed-up so far, for 3-9 months, with cystoscopic review and repeat Makari testing; 75 have still to be followed-up. The high initial positive rate of 37% has been largely explained by the discovery of a recurrent tumour at the first cystoscopy after the test. The concordance between tumour status and repeat Makari testing indicates its ability to detect early recurrence.

Cystoscopy↗
PubMed1977

Prognostic value of serum levels of immunoglobulins (IgG, IgA, IgM and IgE) in breast cancer: a preliminary study.

One hundred and sixty women admitted for breast tumour biopsy to the King's College Hospital group have been followed sequentially for 2 years. Sixty-nine women had early operable breast cancer and 91 had benign breast disease. All these women had serum immunoglobulin IgG, IgA, IgM and IgE levels measured preoperatively and postoperatively at 3 months, 1 year and 2 years. No differences were found in any of the serum immunoglobulin levels between the two groups at any time. There was, however, a positive correlation between the extent of metastatic breast cancer and the serum level of various immunoglobulins, particularly IgA. There was no evidence that routine postoperative radiotherapy influenced the levels of serum immunoglobulins. The findings suggest a secondary defence reaction against increasing tumour load, and do not support the theory of an early immune defect in immunoglobulin metabolism which could play a part in the pathogenesis of breast cancer. Although there is no diagnostic value in measuring the levels of serum immunoglobulins in patients with breast tumours, there may be some value in following the levels in cancer patients, as a guide to subclinical spread of the disease.

Aged↗
PubMed1977

Clinical evaluation of the Makari test in urological malignancies.

The results of a double-blind controlled study of the modified Makari skin test for the detection of cancer are described. The test identified malignant disease in 95% of 37 patients with primary cancer and in 74% of 81 with recurrent cancer after the exclusion of "anergic" patients. The study suggests that the test will be useful in the monitoring of primary treatment and in the detection of recurrent malignancy.

Antigens, Neoplasm↗
PubMed1977

The modified Makari skin test in urology--is it significant?

The Makari test is able to detect the presence of cancer in 95% of patients with primary tumours having excluded anergic patients. The test is useful in monitoring primary treatment. A long-term follow-up is necessary to determine the reason for patients' unexplained positive reactions in a control group of patients.

Clinical Trials as Topic↗
PubMed1977

Serum protein changes in breast cancer: a prospective study.

Sixty women admitted to the King's College Hospital group for biopsy of a lump in the breast have been followed sequentially for one year. Thirty women had early operable breast cancer and 30 had benign breast disease. Each patient had 10 serum proteins measured preoperatively and postoperatively at three months and at one year. The patients with breast cancer had significantly higher levels of beta2 glycoprotein preoperatively and caeruloplasmin at one year postoperatively than those with benign breast disease. There were a number of significant correlations between serum protein levels and the progression of breast cancer as measured by the clinical score. There were significant correlations with caeruloplasmin preoperatively and at three months postoperatively. Prealbumin and haemopexin showed correlations preoperatively; alpha1 antitrypsin and beta2 glycoprotein only correlated at three months postoperatively. A longer follow-up will be required to establish the value of serum protein changes which could predict the development of metastases in patients with breast cancer.

Age Factors↗
PubMed1976

Histocompatibility antigens, autoantibodies, and immunoglobulins in alcoholic liver disease.

Determination of histocompatibility antigens in 63 patients with alcoholic liver disease showed that HLA-B8 was more prevalent in patients with cirrhosis than in controls, but among those with fatty liver and minimal fibrosis the prevalence of this antigen was normal. Another noticeable difference was the absence of HLAA28 in the cirrhotic group. In the total series of 219 patients the prevalence of antinuclear and smooth muscle antibodies was raised; they were especially prevalent in patients with cirrhosis. Raised serum IgA and IgG concentrations were also common (found in 50% and 37% respectively) and were again significantly associated with cirrhosis. In contrast, serum IgM levels, which were raised in 46% of cases, were not significantly related to the presence of cirrhosis but correlated significantly with the degree of portacaval shunting. These results support recent evidence suggesting that immune responses may be implicated in alcohol-induced liver damage, particularly in its progression to cirrhosis.

Adult↗