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Biomedical subjects

D E Sweet

Publications and source records attributed to D E Sweet.

At least 55 records · Page 3Linked to original sources
PubMed1986

Epithelioid hemangioendothelioma and related lesions.

Epithelioid hemangioendothelioma (EH) is the prototype of a group of vascular tumors characterized by an epithelioid or histiocytoid endothelial cell. This family also includes the epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) and epithelioid forms of angiosarcoma. This review discusses the principal clinical, pathologic, and biologic differences among these three lesions. In particular the various manifestations of EH of soft tissue, bone, lung (previously called intravascular bronchioloalveolar tumor), and liver are discussed. Long-term follow-up data of EH of soft tissue and lung are provided.

Bone Neoplasms↗
PubMed1985

Psammomatoid (juvenile) ossifying fibroma of the orbit.

The clinical and pathologic features in 21 cases of a distinctive solitary fibro-osseous lesion affecting the orbit distinguished histologically by the dominance of numerous small round "psammoma-like" ossicles embedded in a cellular benign spindle cell stroma were studied. The patients were predominantly young, and 19 of the lesions were centered on the orbital plate of the frontal bone or ethmoid. A clinical course of slowly progressive symptoms over several years was typical but not uniform. The most common clinical diagnosis was fibrous dysplasia and mucocele. At least nine patients underwent two or more surgical operations; one patient had six recurrences over a 15-year period. There were no known deaths from the tumor, but its potentially massive size can result in considerable morbidity and cosmetic deformity. Although previously referred to as active juvenile ossifying fibroma, the term psammomatoid ossifying fibroma for this lesion is more descriptive and has historical precedence.

Adolescent↗
PubMed1985

Evaluation of H2O2 prophylaxis of bacteriuria in patients with long-term indwelling Foley catheters: a randomized controlled study.

Since the long-term catheterized patient is at significant risk of urinary tract infection, and the catheter drainage bags of these patients are at significant risk of becoming reservoirs for nosocomial pathogens, we carried out a randomized, controlled study to determine the efficacy of intermittent drainage bag instillation of hydrogen peroxide (H2O2) in patients requiring indwelling Foley catheters for 5 days or more. Herein we report the effects of this technique on the rates of catheter and bag bacteriuria, the duration to positive culture, the temporal relationships observed, and the spectrum of organisms recovered. Bag source bacteriuria was found with the same frequency in both control and H2O2 groups. H2O2 did reduce contamination of the drainage bag but did not reduce catheter-associated bacteriuria or frequency of symptomatic urinary tract infection. Furthermore, H2O2 did not reduce the frequency of bag contamination with most of the common nosocomial urinary pathogens.

Antisepsis↗
PubMed1984

Safety of anterior cement fixation in the cervical spine: in vivo study of dog spine.

There is increased use of methylmethacrylate in the treatment of neoplastic lesions of the spine. The advantage of this treatment is immediate stabilization, thus avoiding prolonged immobilization. In vivo study using a dog model showed that anterior fixation with cement, with or without Gelfoam as insulation material, produced no spinal cord injury.

Animals↗
PubMed1981

Radiologic and pathologic analysis of solitary bone lesions. Part I: internal margins.

The interface between tumor and bone that is displayed radiographically is a zone of cellular activity. Its radiographic appearance represents the summation of bone lysis and production. This activity and the radiographic details of the resultant margin are an index of the biologic activity of a lesion. The anatomic site and extent of the lesion can be assessed by radiographs and special imaging techniques. Careful analysis of these patterns, when integrated with clinical data, enhances diagnosis, patient management, and therapy.

Bone Neoplasms↗
PubMed1981

Radiologic and pathologic analysis of solitary bone lesions. Part II: periosteal reactions.

The activated periosteum has a deceptive anatomic constancy amidst change. The change involves the production of matrix and, in the process, proliferation and expenditure of cells. When the demand for a reaction is excessive, nearby extraperiosteal soft tissue serves as a ready source for additional modulating cells, just as it does for fracture callus. The configuration of a periosteal reaction is an index of the nature and intensity of the inciting process.

Bone Neoplasms↗
PubMed1981

Radiologic and pathologic analysis of solitary bone lesions. Part III: matrix patterns.

The mineralized matrix patterns demonstrated in clinical radiographs of primary bone neoplasms and related disorders help to predict matrices, and have diagnostic significance. These radiographic patterns may yield important clues as to the true nature of a lesion, especially when only limited biopsy material is available from extraosseous or nonrepresentative areas. Therefore, in the evaluation of bone tumors and tumor-like conditions, it is of extreme importance to correlate the histologic findings with the radiographic examination and to know precisely the location at which the biopsy material was obtained. Patterns of mineralization may be the only remnants of a pre-existing lesion that has undergone sarcomatous transformation, such as in bone infarcts, enchondromas, or osteochondromas. The pre-eminent item of importance for patient care is the diagnosis of a malignant process. However, failure to appreciate antecedent benign conditions will not contribute toward a better understanding of tumor biology or a determination of those benign lesions that warrant removal or close clinical follow-up. Integration of matrix data with knowledge of the anatomic location of a lesion, the character of its margins, and the periosteal reaction patterns it produces permits prognostication and often, specific diagnosis.

Bone Diseases↗
PubMed1977

Fat-cell changes as a mechanism of avascular necrosis of the femoral head in cortisone-treated rabbits.

Large doses of cortisone were given to growing and adult rabbits over a five-month period to produce avascular necrosis of the femoral head. The cortisone caused an increase in the serum cholesterol, fatty metamorphosis of the liver, and fat emboli visible in sections of the femur and humerus. These emboli partially obliterated the microcirculation of the subchondral vessels of both femoral and humeral heads. The average diameter of the marrow fat cells also increased more than ten micrometers. This increase in cell volume might be significant because in the closed chamber of the femoral head it could increase tissue pressure, diminish perfusion, and be the mechanism for avascular necrosis induced by cortisone.

Animals↗
PubMed1976

Malignant fibrous xanthoma with metastasis to cerebellopontine angle.

Malignant fibrous xanthoma is an uncommon tumor of histiocytic origin. It is a difficult tumor to diagnose, and may have an unpredictable and confusing clinical course. The malignant fibrous xanthoma described herein probably represents the first reported case of metastasis to the cerebellopontine angle. When properly diagnosed, the preferred treatment is wide excision. Metastases are usually to the lungs and regional lymph nodes, and portend a poor prognosis. Radiotherapy appears to be of little value.

Cerebellar Neoplasms↗
PubMed1976

Avascular necrosis in SLE. An apparent predilection for young patients.

Recent reports of avascular necrosis (AN) in systemic lupus erythematosus (SLE) have suggested that its occurrence may be most frequent in young patients. In our population of 99 patients with SLE, 7 young patients have developed AN. Patterns of prednisone therapy had no apparent relationship to the development of AN. AN may become apparent in patients who have relatively inactive lupus, when increased physical activity precipitates articular collapse. A diagnosis of AN should be considered in young patients with localized joint pain.

Adolescent↗
PubMed1976

Ewing's sarcoma.

Explore the source record for details and available documents.

Diagnosis, Differential↗
PubMed1975

Angiography in the diagnosis of osteoid-osteoma of the hand.

Angiographic findings characteristic of osteoid-osteoma are described in two cases of osteoid-osteoma of the bones of the wrist. While the etiology of the disease is not understood, a developmental relationship between the osteoid-osteoma nidus and increased vascularity is suggested.

Adult↗