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Biomedical subjects

D E Rosenblatt

Publications and source records attributed to D E Rosenblatt.

11 recordsLinked to original sources
PubMed1997

Elder mistreatment.

Elder mistreatment is a common clinical problem that affects at least 4% of the population over age 65. It occurs in all socioeconomic and racial groups. If our eyes are open and we know the signs, we will find it in our families, in our communities, in our nursing homes, and in our hospitals. All health care professionals should be familiar with the problem of elder mistreatment, adept at recognizing risk factors for mistreatment, and alert to signs of actual mistreatment. If we can recognize at-risk situations, it may be possible to prevent much of the neglect and self-neglect that constitute the bulk of the APS caseload. At the very least, we certainly must be able to treat any cases of mistreatment that cannot or have not been prevented. Part of the ability to provide care for victims of mistreatment depends on clinical expertise, and part depends on active advocacy for the victims. This means advocating for the patient not only with the caregivers and within the hospital system, but also at the community, state, and federal levels. Without this political advocacy, there will be no resources to back up our clinical exercise. Nurses have already done much to develop the field of elder mistreatment and improve the care of victims of abuse, but there is still a lot of work to do.

Aged↗
PubMed1996

Reporting mistreatment of older adults: the role of physicians.

OBJECTIVE: To characterize elder mistreatment reporting patterns over time and by reporting source with specific focus on physician reporting. To determine whether demographic or socioeconomic factors influenced the reporting of elder abuse in Michigan between 1989 and 1993 and whether these factors affected physician reporting rates. DESIGN: Analysis of the State of Michigan's records of reported cases of suspected adult abuse for the years 1989-1993. MEASUREMENTS: Counties were categorized by size, urbanization, and average income. The study population was analyzed as four age groups: 18-64, 65-74, 75-84, and 85-99. Physician to population ratios were calculated for the county types and compared with physician reporting rates. MAIN RESULTS: A total of 27,371 cases of possible abuse were reported, 17,238 in persons older than age 65. Physicians reported only 2% of cases, and physician reporting rates did not increase over the 5-year period. Physician reporting rates were highest in small counties with low physician to population ratios. There was a high percentage of primary care physicians in these counties. Forty-seven percent of all reported cases were substantiated. There was no difference in substantiation rate for physician-reported cases compared with other professional reporting sources. CONCLUSION: Physician reports average only 2% of all reports of suspected elder mistreatment. Primary care physicians in counties with low physician to population ratios appear to be more active in reporting mistreatment of older people. Increasing physician awareness of the problem of elder mistreatment and providing physicians with the tools to screen for mistreatment should increase the number of cases that are reported to the agencies responsible for assisting mistreated older people.

Adolescent↗
PubMed1991

Protease nexin-1 activity in cultured Schwann cells.

We report that protease nexin-1 (PN-1), a serine protease inhibitor known to have neurite-promoting effects, is made by Schwann cells in tissue culture. Three modalities have been used to demonstrate the presence of PN-1 in Schwann cell cultures. Immunostaining of the cultures with anti-PN-1 antibody gives positive staining over cells and matrix. Western blots of Schwann cell conditioned medium (CM) using anti-PN-1 antibody show a band that co-migrates with the PN-1 standard at 45 kDa. Biochemical assay for protease inhibitory activity shows that CM inhibits thrombin activity in a calorimetric assay. The CM-mediated inhibition of thrombin is reversed if the CM is pre-incubated with anti-PN-1 antibody.

Amyloid beta-Protein Precursor↗
PubMed1989

Protease nexin I immunostaining in Alzheimer's disease.

Immunohistochemical experiments showed that a small subset of neuritic plaques in brains affected by Alzheimer's disease stain positively with an antibody to the protease inhibitor protease nexin I. Nearly all plaques and tangles throughout the brain also showed a heightened avidity for a protease nexin I antibody-antigen aggregate, suggesting that plaques and tangles may have a particularly high density of protease nexin I-binding sites. These observations provide further evidence for a potential disruption of protein processing in the brains of patients with Alzheimer's disease.

Aged↗
PubMed1987

Identification of a protease inhibitor produced by astrocytes that is structurally and functionally homologous to human protease nexin-I.

In the present studies we have compared the structural and biochemical properties of human protease nexin-I (PN-I) and a protease inhibitor present in the serum-free culture fluid of normal rat brain astrocytes. The inhibitor binds to and forms covalent complexes with human urokinase and thrombin. The inhibitor has an approximate Mr = 43,000 based on the size of the complexes (deduced from SDS-PAGE) and mediates the cellular binding and uptake of the proteases to which it links. Binding is heparin sensitive and occurs on a cell surface receptor that also binds complexes formed between proteases and a well-characterized cell-secreted protease inhibitor, human PN-I. In addition, the inhibitor co-migrates with PN-I on SDS-PAGE and cross-reacts with anti-PN-I antibody on immunoblots. A similar molecule, designated NPF, is produced by C6 glioma cells in culture and has neurite promoting activity on a neuroblastoma cell line.

Amyloid beta-Protein Precursor↗
PubMed1986

Rehabilitation home visits.

This chart review study describes 40 geriatric hip fracture patients focusing on the in-home functional and environmental assessment done before discharge from a rehabilitation hospital. Patients were aged 65 to 96 years. Before hospitalization all ambulated independently and three-quarters required limited or no social support. On discharge, none ambulated independently and all required support. Discharge plans for three patients were changed by the home visit, resulting in two nursing home placements. The role and structure of the rehabilitation home visit are outlined together with the common safety recommendations and equipment needs. The home visit assessment form is presented. The rehabilitation home visit is a practical tool to help achieve successful home discharge for elderly hip fracture patients. It is particularly useful in discharge planning for elderly patients with hip fracture, amputation, or stroke.

Activities of Daily Living↗