Biomedical subjects

D E Pritchard

Publications and source records attributed to D E Pritchard.

At least 19 recordsLinked to original sources

PubMed2005

Optical weak link between two spatially separated Bose-Einstein condensates.

Two spatially separate Bose-Einstein condensates were prepared in an optical double-well potential. A bidirectional coupling between the two condensates was established by two pairs of Bragg beams which continuously outcoupled atoms in opposite directions. The atomic currents induced by the optical coupling depend on the relative phase of the two condensates and on an additional controllable coupling phase. This was observed through symmetric and antisymmetric correlations between the two outcoupled atom fluxes. A Josephson optical coupling of two condensates in a ring geometry is proposed. The continuous outcoupling method was used to monitor slow relative motions of two elongated condensates and characterize the trapping potential.

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PubMed2005

Light scattering to determine the relative phase of two Bose-Einstein condensates.

We demonstrated an experimental technique based on stimulated light scattering to continuously sample the relative phase of two spatially separated Bose-Einstein condensates of atoms. The phase measurement process created a relative phase between two condensates with no initial phase relation, read out the phase, and monitored the phase evolution. This technique was used to realize interferometry between two trapped Bose-Einstein condensates without need for splitting or recombining the atom cloud.

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PubMed2004

Quantum reflection from a solid surface at normal incidence.

We observed quantum reflection of ultracold atoms from the attractive potential of a solid surface. Extremely dilute Bose-Einstein condensates of 23Na, with peak density 10(11)-10(12) atoms/cm(3), confined in a weak gravitomagnetic trap were normally incident on a silicon surface. Reflection probabilities of up to 20% were observed for incident velocities of 1-8 mm/s. The velocity dependence agrees qualitatively with the prediction for quantum reflection from the attractive Casimir-Polder potential. Atoms confined in a harmonic trap divided in half by a solid surface exhibited extended lifetime due to quantum reflection from the surface, implying a reflection probability above 50%.

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PubMed2004

Dynamical instability of a doubly quantized vortex in a Bose-Einstein condensate.

Doubly quantized vortices were topologically imprinted in /F=1> 23Na condensates, and their time evolution was observed using a tomographic imaging technique. The decay into two singly quantized vortices was characterized and attributed to dynamical instability. The time scale of the splitting process was found to be longer at higher atom density.

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PubMed2004

Distillation of bose-einstein condensates in a double-well potential.

Bose-Einstein condensates of sodium atoms, prepared in an optical dipole trap, were distilled into a second empty dipole trap adjacent to the first one. The distillation was driven by thermal atoms spilling over the potential barrier separating the two wells and then forming a new condensate. This process serves as a model system for metastability in condensates, provides a test for quantum kinetic theories of condensate formation, and also represents a novel technique for creating or replenishing condensates in new locations.

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PubMed2004

Atom interferometry with Bose-Einstein condensates in a double-well potential.

A trapped-atom interferometer was demonstrated using gaseous Bose-Einstein condensates coherently split by deforming an optical single-well potential into a double-well potential. The relative phase between the two condensates was determined from the spatial phase of the matter wave interference pattern formed upon releasing the condensates from the separated potential wells. Coherent phase evolution was observed for condensates held separated by 13 microm for up to 5 ms and was controlled by applying ac Stark shift potentials to either of the two separated condensates.

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PubMed2003

Cooling Bose-Einstein condensates below 500 picokelvin.

Spin-polarized gaseous Bose-Einstein condensates were confined by a combination of gravitational and magnetic forces. The partially condensed atomic vapors were adiabatically decompressed by weakening the gravito-magnetic trap to a mean frequency of 1hertz, then evaporatively reduced in size to 2500 atoms. This lowered the peak condensate density to 5 x 10(10) atoms per cubic centimeter and cooled the entire cloud in all three dimensions to a kinetic temperature of 450 +/- 80 picokelvin. Such spin-polarized, dilute, and ultracold gases are important for spectroscopy, metrology, and atom optics.

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PubMed2003

Coreless vortex formation in a spinor Bose-Einstein condensate.

Coreless vortices were phase imprinted in a spinor Bose-Einstein condensate. The three-component order parameter of F=1 sodium condensates held in a Ioffe-Pritchard magnetic trap was manipulated by adiabatically reducing the magnetic bias field along the trap axis to zero. This distributed the condensate population across its three spin states and created a spin texture. Each spin state acquired a different phase winding which caused the spin components to separate radially.

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PubMed2003

Bose-Einstein condensates near a microfabricated surface.

Magnetically and optically confined Bose-Einstein condensates were studied near a microfabricated surface. Condensate fragmentation observed in microfabricated magnetic traps was not observed in optical dipole traps at the same location. The measured condensate lifetime was >or=20 s and independent of the atom-surface separation under both magnetic and optical confinement. Radio-frequency spin-flip transitions driven by technical noise were directly observed for optically confined condensates and could limit the condensate lifetime in microfabricated magnetic traps.

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PubMed2003

Sodium Bose-Einstein condensates in the F = 2 state in a large-volume optical trap.

We have investigated the properties of Bose-Einstein condensates of sodium atoms in the upper hyperfine ground state. Condensates in the high-field seeking [F=2, m(F)=-2> state were created in a large volume optical trap from initially prepared [F=1, m(F)=-1> condensates using a microwave transition at 1.77 GHz. We found condensates in the stretched state [F=2, m(F)=-2> to be stable for several seconds at densities in the range of 10(14) atoms/cm(3). In addition, we studied the clock transition [F=1, m(F)=0> --> [F=2, m(F)=0> in a sodium Bose-Einstein condensate and determined a density-dependent frequency shift of (2.44+/-0.25+/-0.5) x 10(-12) Hz cm(3).

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PubMed2002

Imprinting vortices in a Bose-Einstein condensate using topological phases.

Vortices were imprinted in a Bose-Einstein condensate using topological phases. Sodium condensates held in a Ioffe-Pritchard magnetic trap were transformed from a nonrotating state to one with quantized circulation by adiabatically inverting the magnetic bias field along the trap axis. Using surface wave spectroscopy, the axial angular momentum per particle of the vortex states was found to be consistent with 2 variant Planck's over 2pi or 4 variant Planck's over 2pi, depending on the hyperfine state of the condensate.

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PubMed2002

Contrast interferometry using Bose-Einstein condensates to measure h/m and alpha.

The kinetic energy of an atom recoiling due to absorption of a photon was measured as a frequency, using an interferometric technique called "contrast interferometry." Optical standing wave pulses were used to create a symmetric three-path interferometer with a Bose-Einstein condensate. Its recoil phase, measurable with a single shot, varies quadratically with additional recoils and is insensitive to errors from vibrations and ac Stark shifts. We have measured the photon recoil frequency of sodium to 7 ppm precision, using a simple realization of this scheme. Plausible extensions should yield sufficient precision to attain a ppb-level determination of h/m and the fine structure constant alpha.

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PubMed2002

Propagation of Bose-Einstein condensates in a magnetic waveguide.

Gaseous Bose-Einstein condensates of 2-3 x 10(6) 23Na atoms were loaded into a microfabricated magnetic trap using optical tweezers. Subsequently, the condensates were released into a magnetic waveguide and propagated 12 mm. Single-mode propagation was observed along homogeneous segments of the waveguide. Inhomogeneities in the guiding potential arose from geometric deformations of the microfabricated wires and caused strong transverse excitations. Such deformations may restrict the waveguide physics that can be explored with propagating condensates. Finer perturbations to the guiding potential fragmented the condensate when it was brought closer to the surface.

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PubMed2002

A continuous source of Bose-Einstein condensed atoms.

A continuous source of Bose-Einstein condensed sodium atoms was created by periodically replenishing a condensate held in an optical dipole trap with new condensates delivered using optical tweezers. The source contained more than 1 x 10(6) atoms at all times, raising the possibility of realizing a continuous atom laser.

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PubMed2001

Transport of Bose-Einstein condensates with optical tweezers.

We have transported gaseous Bose-Einstein condensates over distances up to 44 cm. This was accomplished by trapping the condensate in the focus of an infrared laser and translating the location of the laser focus with controlled acceleration. Condensates of order 10(6) atoms were moved into an auxiliary chamber and loaded into a magnetic trap formed by a Z-shaped wire. This transport technique avoids the optical and mechanical access constraints of conventional condensate experiments and creates many new scientific opportunities.

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PubMed2001

Observation of vortex phase singularities in Bose-Einstein condensates.

We have observed phase singularities due to vortex excitation in Bose-Einstein condensates. Vortices were created by moving a laser beam through a condensate. They were observed as dislocations in the interference fringes formed by the stirred condensate and a second unperturbed condensate. The velocity dependence for vortex excitation and the time scale for re-establishing a uniform phase across the condensate were determined.

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PubMed2001

From single- to multiple-pPhoton decoherence in an atom interferometer.

We measure the decoherence of a spatially separated atomic superposition due to spontaneous photon scattering. We observe a qualitative change in decoherence versus separation as the number of scattered photons increases, and verify quantitatively the decoherence rate constant in the many-photon limit. Our results illustrate an evolution of decoherence consistent with general models developed for a broad class of decoherence phenomena.

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PubMed2001

Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts.

The cellular responses to carcinogen exposure influence cellular fate, which in turn modulates the neoplastic response. Certain hexavalent chromium [Cr(VI)] compounds are implicated as occupational respiratory carcinogens at doses that are both genotoxic and cytotoxic. We examined the mechanism of Cr(VI)-induced apoptosis in normal human fibroblasts (BJ) immortalized by human telomerase gene transfection (BJ-hTERT), and we assessed the spectrum of cumulative cellular fates [(a) regaining of replicative potential; (b) terminal growth arrest; or (c) apoptosis] for a narrow range of increasingly genotoxic doses of Cr(VI). Exposure of BJ-hTERT cells to Cr(VI) resulted in a dose-dependent increase in apoptosis that involved mitochondrial disruption as evidenced by mitochondrial membrane depolarization and cytochrome c release. The initial response to Cr(VI) exposure was inhibition of cell cycle progression. At the lowest dose tested (1 microM; 32% clonogenic survival), the cell cycle inhibition led to terminal growth arrest but no apoptosis. The fraction of terminally growth arrested cells increased as the dose was increased to 3 microM but then decreased at 4, 5, and 6 microM as apoptosis became the predominant cell fate. Our results suggest that cell populations exposed to Cr(VI) have a different spectrum of responses, depending on the extent of DNA damage, and that the regaining of replicative potential after relatively higher genotoxic exposures may be attributable to either escape from, or resistance to, terminal growth arrest or apoptosis.

Apoptosis↗