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Biomedical subjects

D E Powell

Publications and source records attributed to D E Powell.

82 records · Page 5Linked to original sources
PubMed1970

Cellular contamination during automatic and manual staining of cytological smears.

Three routine cervical smears were contaminated with adenocarcinoma cells from a malignant serous effusion which was being processed simultaneously in an automatic staining machine. Further investigation showed that cells were transferred in up to 17% of cases. However, with manual staining, the figure could be as high as 30%. The possibility of misleading cellular transfer should therefore always be considered. Serious fluids should not be processed with routine cervical smears.

Adenocarcinoma↗
PubMed1969

Effect of drugs on vitamin B 12 levels obtained using the Lactobacillus leichmanii method.

In 750 consecutive assays of serum vitamin B(12) levels using Lactobacillus leichmanii, 25 (3.3%) showed inhibition. A satisfactory history of drug therapy was obtained in 23 cases. Seventeen of these were receiving ampicillin at the time. Two patients showed inhibition while receiving phenoxmethyl penicillin or phenethicillin. A prospective study of 11 patients detected inhibition in seven at varying intervals during ampicillin therapy. It was shown that the vitamin B(12) as measured by the radioisotope and Euglena gracilis methods was not affected. Inhibition of L. leichmanii was reproduced in vitro with concentrations of ampicillin corresponding to those obtained in therapy. Benzylpenicillin, streptomycin, and chloramphenicol had no such effect.A prospective study of patients receiving chlorpromazine yielded negative results.Inhibition may occasionally be seen in the absence of any known intake of drugs. Measurement by other methods may be required to distinguish this from vitamin B(12) depletion.

Ampicillin↗