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Biomedical subjects

D E Osborn

Publications and source records attributed to D E Osborn.

At least 37 records · Page 2Linked to original sources
PubMed1986

Antibiotic prophylaxis and secondary haemorrhage following transurethral resection of the prostate: a prospective trial.

One hundred and sixty-two patients were studied in a random double-blind controlled trial of co-trimoxazole to prevent secondary haemorrhage following transurethral resection of the prostate (TURP). There was a significant correlation between the incidence of post-operative urinary infection and secondary haemorrhage (P less than 0.05) but no difference between the incidence of bleeding in the treatment and placebo groups. Although infection may play a role in the development of secondary haemorrhage, co-trimoxazole for 10 days does not decrease the incidence of this complication.

Aged↗
PubMed1985

Ectopic ureterocele in an adult with prolapse through the urethra.

Most ureteroceles in adults are incidental findings at excretory urography. Symptomatic ureteroceles are unusual and prolapse of the ureterocele is particularly uncommon. We describe a woman with prolapse of a ureterocele through the urethra, which resulted in strangulation and partial necrosis of the ureterocele wall.

Adult↗
PubMed1984

Routine cross-matching is not necessary for a transurethral resection of the prostate.

Two hundred and fifty-five consecutive patients undergoing transurethral prostatectomy were studied prospectively to test a policy of not routinely cross-matching blood. Blood was ordered only for patients with anaemia, a major medical risk factor, a prostate gland estimated to be greater than 60 g, or the presence of red cell alloantibodies. Of the 203 patients who were "grouped and saved" only, 30 (12%) were subsequently cross-matched and 22 (8.5%) transfused. There were no significant problems as a result of the operation of this policy. The value of these pre-operative criteria for cross-matching was confirmed, apart from the clinical estimation of prostatic size. The use of such a policy could be of significant value to the hospital blood transfusion services.

Aged↗
PubMed1982

Factors influencing salvage cystectomy results.

Analysis of 86 patients who underwent salvage cystectomy following a radical course of radiotherapy for bladder cancer and 37 patients who underwent primary cystectomy has shown a greater survival for women than men. The following factors were associated with a significant deterioration in survival: 1. Age at time of cystectomy: post-operative mortality and tumour recurrence are greater over the age of 70. 2. Non-function of one kidney on IVU. 3. Grade 3 tumour on cystectomy specimen. 4. pT3 or pT4 tumour on cystectomy specimen.

Age Factors↗
PubMed1981

Renal imaging: a comparison of radionuclide, ultrasound, and computed tomographic scanning in investigation of renal space-occupying lesions.

Two studies were carried out in which 27 and 23 patients respectively with renal space-occupying lesions were assessed by different techniques and the results compared. Instead of proceeding to renal arteriography after the lesion had been found on urography, radionuclide and ultrasound scanning were used in the first study to clarify the nature of the lesions, while in the second study computed tomography was used as well. Results were good with all three methods, although ultrasonography and radionuclide scanning cannot resolve lesions of under 2 cm in diameter and the radiation dose with computed tomography is similar to that used in renal arteriography. Probably the best method of evaluating renal space-occupying lesions after urography is to use both ultrasound and radionuclide scanning. If further information is required computed tomography or arteriography is indicated.

Adenocarcinoma↗
PubMed1981

Surgical management of idiopathic retroperitoneal fibrosis.

The management of 10 patients with idiopathic retroperitoneal fibrosis causing obstructive uropathy is presented. In all cases the obstruction was relieved by ureterolysis and corticosteroid therapy was not used during the initial treatment. In 9 patients the operation was well tolerated but one, who developed a pyonephrosis after pre-operative ureteric drainage, died of septiceamia 15 days post-operatively. In 2 patients further explorations and ureterolysis were necessary for recurrent fibrosis which may have been related to urinary leakage. A policy for the management of these cases is presented which recommends the use of silastic tubing splints after ureteric mobilisation and the use of an omental wrap.

Adult↗
PubMed1981

Symptomatic renal angiomyolipoma.

Two cases of symptomatic renal angiomyolipoma not associated with tuberous sclerosis are presented. The clinical and radiological features, the pathology and the management of these rare but well documented tumours are briefly discussed. They pose problems in diagnosis and controversy still exists regarding their management. Recent radiological techniques such as CT may help in the diagnosis. When conservative surgery is not possible, or when an adenocarcinoma cannot be confidently excluded, nephrectomy should be performed.

Adult↗
PubMed1977

Malakoplakia in a cadaver renal allograft: a case study.

Malakoplakia is an uncommon chronic inflammatory disease characterized by histocytes with intracellular Michaelis-Gutmann bodies. The etiology is uncertain, but it is thought that depressed macrophage phagocytosis of bacteria is important. This presentation describes a case of malakoplakia arising in a cadaver renal transplant. The association of long term immunosuppression and repeated E. coli urinary tract infections is discussed.

Cadaver↗
PubMed1977

Effects of C. parvum on growth and induction of intracerebral tumours in mice.

An investigation was made into the effect of Corynebacterium parvum therapy on cerebral tumours in mice. I.v. C. parvum caused a slight but significant increase in the survival of BALB/c mice injected intracerebrally (i.c.) with not more than 50 Meth A cells. C. parvum was most effective if given on the same day or 5 days after tumour. If this interval was increased there was no effect. Multiple i.v. injections were no more effective than a single dose. I.v. C. parvum had no influence on the survival of C57BL mice injected i.c. with Lewis tumour cells, and had little effect on the induction of i.c. or s.c. tumours by methylcholanthrene. It was concluded that C. parvum therapy was of little use in the treatment of cerebral tumour in mice. The clinical implications of these findings are discussed.

Animals↗