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Biomedical subjects

D E Griesdale

Publications and source records attributed to D E Griesdale.

3 recordsLinked to original sources

Lymphocytic adenohypophysitis.

Lymphocytic adenohypophysitis (LAH) is an uncommon disorder in the spectrum of pituitary disease. Twenty-three cases proven by biopsy or at autopsy have been reported since 1962. We report 2 further cases and review the etiology, immunology and pathology of the disease. The diagnosis should be considered in a female patient who presents during the post-partum period with the clinical picture of a non-functional or prolactin cell pituitary adenoma and evidence of hypopituitarism.

Adult↗

Transseptal, transsphenoidal surgery: a subjective and objective analysis of results.

Transseptal, transsphenoidal surgery in British Columbia is performed as a joint procedure between otolaryngology and neurosurgery. We analysed the 84 procedures performed on 78 patients between 1978 and 1983 at St. Paul's Hospital in Vancouver. A questionnaire was completed by 66 patients (85%) which examined the patients' subjective assessment of the success of the surgery. A postoperative review demonstrated 18 postoperative nasal complications (21%) consisting of seven septal perforations (8%), 10 synechiae (12%) and one septal abscess (1%). The majority of these complications were asymptomatic. Subsequent modifications of the operative technique are discussed. Our assessment of the overall success of this surgery was confirmed by the fact that 97% of respondents stated that they would undergo the primary surgery again, 17% of these with some reservations. Only 3% would now refuse the primary surgery.

Acromegaly↗