The later stages of porphyrin biosynthesis.
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Biomedical subjects
Publications and source records attributed to D E Games.
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The use of ;shift reagents' in the determination of n.m.r. spectra, and of reductive alkylation in combination with g.l.c.-mass spectrometry, facilitates assignment of the order of substituents in porphyrins, and the application of these new techniques to isocoproporphyrin is described.
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Extracts of urinary nucleosides have been sequentially purified and examined by mass spectrometric analysis. Seventeen modified nucleosides have been unequivocally identified and a further five provisionally identified. While several nucleosides were found only in a small number of extracts, the occurrence and levels of others were found to correlate with the tumour type and stage.