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Biomedical subjects

D E Cross

Publications and source records attributed to D E Cross.

35 records · Page 2Linked to original sources
PubMed1977

Possible evidence for a new C-locus specificity: studies of the serum Pullium.

We have presented data from our own experience and from the first serum exchange of the HLA Workshop of the Americas that indicate the serum Pul may identify a new low-frequency specificity of the C locus. One informative family has been studied, and the results are consistant with a C-locus inheritance pattern. No correlation was found with antisera that identify known antigens of the A, B, or C locus. One additional serum, also available for study, seems to react with the same specificity as the serum Pul.

Adolescent↗
PubMed1976

Organized kidney retrieval on a regional basis. A new approach.

A network of small to medium-sized communities has been developed to increase the supply of cadaveric kidneys for renal allotransplantation. After a training period, community physicians and the community hospitals were designated as members of the transplant team to retrieve kidneys. A threefold increase in the number of cadaveric kidneys has resulted from this project. This mechanism for organized kidney retrieval on a regional basis could be used to augment the supply of cadaveric organs in other areas of the United States.

Hospitals, Community↗
PubMed1976

Self- versus investigator-administered presumed fluency reinforcing stimuli.

The effects of self-administered and investigator-administered presumed fluency reinforcing monetary rewards for perceived fluency increases on the disfluency frequency rate of 17 adult stutterers were studied. Subjects read aloud during 11 one-minute segments under three conditions: one in which no reinforcer was administered at the end of each one-minute segment, a self-administered reinforcement condition, and an investigator-administered reinforcement condition. Although less stuttering was found in the two experimental conditions (with significantly less stuttering occurring in the self-administered fluency reinforcing condition than in the control condition), an increase in stuttering was observed in those reading segments which followed the administration of presumed fluency reinforcing stimuli. These results were interpreted to suggest that although the concept of self-reinforcement may be clinically useful, the operant learning paradigm may be insufficient in providing an adequate description of the events taking place following the administration of fluency contingent reinforcing or punishing stimuli.

Adolescent↗
PubMed1976

Importance of the autocontrol crossmatch in human renal transplantation.

The killing of donor cells in the standard lymphocyte crossmatch is considered strong evidence for preformed antibodies in the recipients's serum. Moreover, it is generally accepted that presensitization has occurred if any of the stored sera kill the donor cells. In our hands, if either the current or the stored sera kill the donor cells, it precludes transplantation. In nine cases we discovered that the recipient's sera also killed the recipient's own lymphocytes, a positive autocontrol test, indicating that factors other than conventional preformed cytotoxic antibodies were responsible for the positive standard crossmatch. The nine patients who demonstrated a positive standard crossmatch and a positive autocontrol for those sera received cadaver allografts. None of the kidneys were rejected hyperacutely and all are functioning adequately. We conclude that the autocontrol crossmatch is an important adjunct for uncovering false positive reactions in the standard lymphocyte crossmatch test.

Adolescent↗
PubMed1976

Prognosis for recovery of function in acute renal failure. Value of the renal image obtained using iodohippurate sodium I 131.

Twenty-four survivors of acute, nonobstructive, nonnephritic renal failure had a renal scan using iodohippurate sodium I 131 performed early in the acute illness. Scans were judged according to whether the renal images were prominent, faint, or absent during the first 30 minutes after intravenous injection of 100 to 250 microcuries of iodohippurate sodium I 131. All ten patients with prominent renal images attained life-sustaining renal function with an average postrecovery creatinine clearance of 80 ml/min. Of the seven patients with faint renal images, six recovered life-sustaining renal function (average creatinine clearance of 39 ml/min), and one required chronic hemodialysis. Seven patients had no renal image initially; four recovered life-sustaining renal function with an average creatinine clearance of 25 ml/min; three required chronic hemodialysis. We conclude that, for patients with acute renal failure, the appearance of the renal image obtained using this substance is an important indicator of renal viability and of the likelihood for functional recovery.

Acute Kidney Injury↗
PubMed1975

Tracheal cuffs. A review and dynamic pressure study.

The sequelae following prolonged tracheal intubation are reviewed. The virtues of large volume low pressure cuffs are confirmed, and the dynamic variations of pressure both within the airway and within the cuff of standard and floppy cuffed tubes have been re-appraised.

Anesthesia, Endotracheal↗
PubMed1975

The influence of protein concentration of the perfusate on weight gain and kidney transplant outcome.

We have described a technique to compare parameters of perfusion using canine kidneys. Using this system, we observed that weight gain during pulsatile perfusion varied inversely with perfusate albumin concentration. The weight gain was more rapid with albumin concentration below 4.0 Gm%. Perfusion characteristics deteriorated in association with early rapid weight gain, indicating greater ischemic damage to the kidneys perfused with the low protein perfusate. Finally, the protein concentration of cryoprecipitated plasms is low enough to cause a rapid increase in kidney weight, a condition predisposing to poor function upon re-implantation of the kidney.

Albumins↗