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Biomedical subjects

D E Bush

Publications and source records attributed to D E Bush.

27 records · Page 2Linked to original sources
PubMed1985

Global cardiac remodeling after acute myocardial infarction: a study in the rat model.

Infarct expansion, regional dilation and thinning of the infarct zone, occurs within 1 day after myocardial infarction. Whether the early change in regional shape of infarct expansion affects the architecture of remote normal regions is unknown. To study this question, 45 rats with a transmural infarct were killed at 1, 2 and 3 days after infarction and their hearts were examined for infarct size and extent of expansion. Wall thickness and radius of curvature were measured within, adjacent to and remote from the infarct zone. Equivalent regions were analyzed in eight control hearts. The extent of disproportionate wall thinning and increased radius of curvature within the infarct zone of hearts with expansion was not dependent on infarct size. Significant wall thinning and increased regional radius of curvature were also seen in adjacent and remote regions of the hearts with expansion (p less than 0.001). These structural changes outside of the infarct occurred independent of infarct age and size, and were not seen in hearts without infarct expansion. Thus, when disproportionate thinning and dilation occur in the infarct region, they are accompanied by a distortion in shape of the entire heart including remote normal myocardium. This remote remodeling of noninfarcted myocardium correlates with extent of expansion, but not with age or size of the infarct.

Animals↗
PubMed1984

Management of patients with hypertension and angina pectoris.

Management of patients with concomitant hypertension and angina pectoris mandates that the physician pay attention to the underlying pathophysiology. The heart, when exposed to years of hypertension, becomes "remodeled." Overall mass is enlarged, the walls are thickened, and initial cavity volume remains normal or relatively small. Left ventricular end-diastolic pressure rises in the setting of a hypertrophic noncompliant ventricle; coronary resistance and coronary perfusion pressure are increased; and coronary vascular reserve, even with widely patent coronary arteries, is decreased. Long-standing hypertension--a risk factor for coronary atherosclerosis--is often accompanied by epicardial coronary stenoses that aggravate these coronary abnormalities. In managing the patient with hypertension and angina pectoris, it is important to determine whether the angina occurs in the setting of hypertensive hypertrophic disease alone or coexists with coronary arterial stenoses. Also important to therapy is whether the ventricle is of normal size with good function or decompensated with dilatation and diminished function. The latter two anatomic considerations, namely, epicardial coronary patency and left ventricular cavity size, will influence the choice of an anti-ischemic regimen. For example, diuretic and nitrate therapy can be hazardous, and digitalis unnecessary, in the setting of a nondilated hypertrophic ventricle with hyperdynamic function. On the other hand, the combined use of beta blocking agents plus calcium antagonists is particularly effective in lowering blood pressure and in improving coronary blood flow. Finally, this combination has been shown to be rapidly effective and to have prolonged benefit in this setting. The choice of these latter agents is also affected by the underlying state of the ventricle. Calcium channel blocking agents without significant negative inotropic effect, such as nifedipine and nitrendipine, would be suitable in patients with decompensated ventricular function and dilated left ventricular cavities. Both of these drugs have been shown to increase cardiac output and contractility via a reflex effect and to have little or no direct negative inotropic effect. In contrast, verapamil has a direct negative inotropic effect. The final choice of agents must be tailored to the needs of the individual patient, and the physician also has to determine the role of specific agents in the natural history of hypertensive heart disease.

Adrenergic beta-Antagonists↗
PubMed1983

Influence of a "discharge interview" on patient knowledge, compliance, and functional status after hospitalization.

Physicians commonly assume that they can educate hospitalized patients to follow prescribed treatment plans after discharge. In a prospective, controlled study, we assessed the effectiveness of a discharge interview given to each of 545 hospitalized patients assigned to one of four groups: a group in which the physicians caring for the patients received a 35-minute tutorial on how to conduct a discharge interview (n = 181), a group that received a 15-minute discharge interview from an investigator (n = 53), a group that received both interventions (n = 63), or a control group (n = 248). One month after discharge, all patients were telephoned, and a standardized questionnaire was administered. Results revealed that, 1 month after discharge, there were no significant differences among the four groups in knowledge of diagnosis, symptom status, activity level, medication knowledge and compliance, appointment keeping, and rates of rehospitalization. These results suggest that effective inpatient education may require more than a discharge interview.

Evaluation Studies as Topic↗
PubMed1980

A multipurpose transfer cage for baboons.

A three tiered combination squeeze and transfer cage for baboons was constructed. With this cage one employee could perform tasks previously requiring two or three animal handlers.

Animals↗
PubMed1977

The reproductive cycle of the capuchin (Cebus apella).

Six, mature female capuchins, Cebus apella, were used to study occurrence of bleeding, the length and phases of the menstrual cycle, and the gestation period. During a 3-month period the menstrual cycle was determined to be 21 days, including an average of 4 days in which bleeding was detectable. It was found that only proestrus and estrus could be reliably identified during the menstrual cycle by the use of vaginal smears. Each female was housed with a male for a sufficient time to allow insemination. Four became pregnant. Three had term pregnancies and one aborted. The other two remained barren. The average gestation period for the three normal pregnancies was 153 days.

Animals↗
PubMed1975

A spontaneous neuropathy of free-ranging Japanese macaques.

Thirteen cases of a spontaneous neuropathy were observed among 150 free-ranging Japanese snow monkeys (Macaca fuscata). Necropsy of 4 individuals revealed lesions in the peripheral and central nervous systems. Pathologic changes were associated with ingestion of coyotillo berries (Karwinskia humboldtiana).

Animals↗
PubMed1975

Semen evaluation in capuchin monkeys (Cebus apella).

Semen from 3 adult male capuchin monkeys (Cebus appella) was collected and evaluated, utilizing an electroejaculator and different collection media. In the first 24 samples collected, no liquid fraction was found. Procedures were then directed toward liquefying the entire coagulum by enzymes for semen evaluation. The enzyme system first utilized consisted of varying percentages of trypsin in 2.5% dextrose in half-strength lactated Ringer's solution. Because of high spermatozoan abnormalities using this mixture, a new enzyme solution was used. This solution consisted of 1% pronase in Eagle's medium, containing Earles' salts. At the end of the experiment, natural mating was allowed. The semen collected from the vagina revealed similar consistency, volume, and sperm concentration when compared with artificially collected samples.

Animals↗