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Biomedical subjects

D E Andersson

Publications and source records attributed to D E Andersson.

26 records · Page 2Linked to original sources
PubMed1981

Calcium and calcium-antagonistic effects on prolactin and growth hormone responses to thyrotropin-releasing hormone and L-dopa in man.

The significance of calcium for the responsiveness of human lactotrophs and somatotrophs to iv TRH and oral L-dopa was investigated in 11 young healthy women. Both TRH and L-dopa were administered on three different background infusions: 1) saline, 2) verapamil, and 3) calcium. Twenty-five micrograms of TRH raised the PRL level from 15.1 +/- 2.3 to 76.9 +/- 8.8 ng/ml in 15 min (P less than 0.001). Calcium infusion blunted this PRL response by 33 +/- 8% (P less than 0.02), whereas verapamil, known for its calcium-antagonistic properties, left in unaffected. Five hundred milligrams of L-dopa increased the GH level from 2.2 +/- 0.7 to 16.7 +/- 2.2 ng/ml in 60 min (P less than 0.002) and reduced the PRL level from 11.6 +/- 2.9 to 3.1 +/- 0.4 ng/ml in 150 min (P less than 0.05). Neither calcium nor verapamil influenced these GH and PRL responses significantly. These findings indicate that human somatotrophs may be less dependent than human lactotrophs on normocalcemia for adequate hormone secretion.

Adult↗
PubMed1980

Effect of verapamil on glucose response to intravenous injection of glucagon and insulin in healthy subjects.

The present investigation was carried out in 16 healthy subjects in order to study whether calcium antagonism would affect the hypoglycemic response to insulin, and/or whether it would affect the insulin and glucose responses to glucagon. For this purpose verapamil, a potent calcium-blocking agent, was used. Verapamil infused alone did not affect the basal insulin or glucose concentrations. However, such infusion reduced the hypoglycemic response to insulin. Furthermore, the glucose response to glucagon was augmented by simultaneous infusion of verapamil, whereas the insulin response to glucagon was unaffected. When healthy volunteers were simultaneously infused with both calcium and verapamil the glucose response to glucagon was no longer augmented. The insulin response to glucagon also remained unaffected. These findings indicate that intravenous verapamil has hyperglycemic effects, unrelated to insulin, under certain conditions. They also imply that exogenous hypercalcemia counteracts the augmentative effect of verapamil on the glucose response to glucagon.

Adult↗
PubMed1980

Effect of verapamil on blood glucose and serum insulin in patients with hyper- and hypothyroidism.

This investigation was carried out in order to study whether calcium antagonism may affect the basal peripheral venous insulin and/or glucose concentration in patients with abnormal thyroid function. For this purpose verapamil, a calcium blocking agent, was infused i.v. over a period of 180 min into 5 thyrotoxic, 4 hypothyroid and, for comparison 5 healthy controls. In the thyrotoxic group, verapamil induced a significant fall in glucose from 60 min on, whereas it had no significant effect on the concomitant insulin concentration. After 4-9 months, 4 of the 5 patients in this group were reinvestigated when euthyroid due to antithyroid treatment. At that time verapamil was without effect on both insulin and glucose concentrations. In the hypothyroid patients, verapamil brought about a transient but significant increase in insulin. Accordingly, insulin had increased by 93 +/- 14% (p < 0.01) after 30 min. From 60 min on it had returned to the control level. The blood glucose concentration tended to fall in response to the infusion, but never reached significantly below the control level. When 3 of the 4 hypothyroid patients were reinvestigated in an euthyroid state after 2-4 months of oral thyroxine substitution, verapamil did not affect either the insulin or the glucose concentration. In the healthy subjects verapamil was without effect on both the insulin and glucose concentrations. This study thus demonstrates an abnormal and different insulin-glucose response pattern to verapamil infusion in untreated hyper- and hypothyroid patients, which can be restored to normal by medical treatment, rendering these patients euthyroid.

Adult↗
PubMed1980

Reversible bone marrow granulomas-adverse effect of oxyphenbutazone therapy.

A 48-year-old woman treated with oxyphenbutazone developed fever, gastrointestinal disturbances, mucocutaneous reactions, leukopenia, eosinophilia and thrombocytopenia. Bone marrow biopsy showed granulomatous lesions. Following withdrawal of the drug, all signs and symptoms subsided and the blood changes and the bone marrow biopsy normalized. The granulomatous reaction in the bone marrow is considered to be a hypersensitivity manifestation of oxyphenbutazone.

Bone Marrow↗
PubMed1978

Four cases of long-standing diarrhoea and colic pains cured by fructose-free diet--a pathogenetic discussion.

Four patients with a long history of abdominal swelling, colic pains and diarrhoea were cured by a fructose-free diet. They were all given an oral load of (14C) fructose and their expiratory excretion of 14CO2 was found to be significantly lower than that of control patients with similar symptoms. It is concluded taht the patients cured by a fructose-free diet might have a partial fructose malabsorption.

Adult↗