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Biomedical subjects

D E Anderson

Publications and source records attributed to D E Anderson.

At least 199 records · Page 11Linked to original sources
PubMed1977

Breast cancer in families.

An analysis of 489 breast cancer pedigrees was conducted to determine the age at diagnosis and bilaterality rate in 887 patients with different familial patterns of the disease compared with 5,100 unselected patients, and to estimate the lifetime probabilities of breast cancer development in 983 daughters of familial patients. The familial patients had higher rates of bilaterality and were younger at diagnosis than patients in an unselected series. Bilaterality rates were highest in young patients. Familial bilateral patients developed their first primaries about 5 years earlier than unilateral patients. Daughters of patients with any type of family history of breast cancer exhibited a 23% lifetime probability for the disease. The highest probability (27%) pertained to daughters of patients whose mothers were also affected, and it was concluded that this group referred to a hereditary type of breast cancer distinct from types involving associated neoplasms. The occurrence of multiple neoplasms characterizes the hereditary types of breast cancer.

Adult↗
PubMed1977

Comparison of biofeedback pulse wave velocity and progressive relaxation on essential hypertensives.

In a study undertaken to evaluate the clinical effectiveness of two behavioral treatments for essential hypertension (biofeedback on arterial pulse-wave velocity and progressive relaxation) 24 hypertensive subjects were randomly assigned to either a relaxation or biofeedback treatment group for 5 weekly sessions. In a second stage of the study 16 of the original subjects received both biofeedback and relaxation treatments during 5 additional weekly sessions. Results indicated that biofeedback and relaxation were equally effective in initial lowering of blood pressure in hypertensives. Although biofeedback training lead to superior reductions at the 3-mo. follow-up point, after 1 yr. the blood pressures of both groups were not only equal but well below those presented at the beginning of the study.

Adult↗
PubMed1976

Aryl hydrocarbon hydroxylase and 16alpha-hydroxylase in cultured human lymphocytes.

Aryl hydrocarbon hydroxylase and 16alpha-hydroxylase were examined in intact, cultured human lymphocytes. The two microsomal mixed-function oxygenases had different pH optima and showed competitive inhibition for enzyme induction and activity. Population distributions were lognormal for both enzymes, giving apparent evidence for polygenic control. Induced levels of AHH were slightly higher among first-order relatives of lung or colon cancer patients than in the control group. The correlation coefficient (r) for AHH and SAH coinducibility was -0.08, indicating no correlation and suggesting the absence of association between the two enzymes in man.

Aryl Hydrocarbon Hydroxylases↗
PubMed1976

Epithelioma adenoides cysticum: genetic update.

Epithelioma adenoides cysticum (EAC) is a well-known genodermatosis which follows an autosomal dominant mode of inheritance. Questions still remain, however, concerning an apparent excess of females with EAC. An analysis of nineteen previously published pedigrees and one newly ascertained pedigree, which in the aggregate included over 175 cases of EAC, induced no excess of affected females, but rather, a marked deficit males. This deficiency was not the consequence of sex linkage or decreased viability, and was most evident in large pedigrees and sibships, sibships not including the probands, and late birth orders. In these situations, the penetrance of EAC in male gene carriers was only 50%, but was close to 100% in female gene carries. Under maximum detection conditions, i.e. small pedigrees, small sibships, sibships containing the proband, and early birth orders, the penetrance in males increased to 85% and was again close to 100% in females. These findings suggested that the deficit of affected males was best explained by a comination of lessened expressivity and penetrance, effects which were magnified under situations of poor detection. A review of familial cases of EAC indicated no consistent associated anomalies such as those that characterize the naevoid basal cell carcinoma syndrome.

Adolescent↗
PubMed1976

Transformation of epithelioma adenoides cysticum into multiple rodent ulcers: fact or fallacy. A historical vignette.

This historical study has examined the persistent controversy about the propensity of epithelioma adenoides cysticum (EAC) to transform into multiple rodent ulcers, by reviewing cases reported through the years that seemed to support the idea. After focusing on the biological behaviour and natural history of the tumours and comparing them with our present knowledge of the behaviour of EAC, we believe that these cases were incorrectly diagnosed. Rather than EAC, they were probably examples of the naevoid basal cell carcinoma syndrome. The latter syndrome was actually established by the recognition that patients who have multiple rodent ulcers that appear early in life and behave aggressively usually have a constellation of associated developmental defects and that the tumours sould be classified as genetically determined basal cell carcinomas and not as EAC.

Adolescent↗
PubMed1975

Induction of 16alpha-hydroxylase in cultured human lymphocytes.

Lymphocytes grown for 72 hr in the presence of mitogenic agents exhibited a nine-fold increase in 16alpha-hydroxylase activity over a 24-hr period following the addition of 17beta-estradiol as an inducing agent. The major metabolite of 17beta-estradiol produced by induced lymphocytes showed a chromatographic mobility indistinguishable from that of estriol. Enzymatic activity increased linearly with cell numbers, was inhibited by CO, and exhibited no induced increase in the presence of cycloheximide. A population survey indicated about 68% of a randomly selected Caucasian group to be essentially uninducible for 16alpha-hydroxylase.

Aryl Hydrocarbon Hydroxylases↗