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D Dykhuizen

Publications and source records attributed to D Dykhuizen.

5 recordsLinked to original sources
PubMed1978

Transport by the lactose permease of Escherichia coli as the basis of lactose killing.

Lactose killing is a peculiar phenomenon in which 80 to 98% of the Escherichia coli cells taken from a lactose-limited chemostat die when plated on standard lactose minimal media. This unique form of suicide is caused by the action of the lactose permease. Since uptake of either lactose or galactose by the lactose permease caused death, the action of rapid transport across the membrane must be the cause of the phenomenon. Alternative causes of lactose killing, such as accumulation of toxic metabolic intermediates or action of the beta-galactosidase, have been eliminated. It is proposed that rapid uptake of sugars by the lactose permease disrupts membrane function, perhaps causing collapse of the membrane potential.

Biological Transport↗
PubMed1978

The influences of a lambda prophage on the growth rate of Escherichia coli.

A lambda prophage increases the competitive ability of E. coli K12 in a glucose-limited chemostat. This phenomenon does not involve the lambdarex gene. Expression of the lambdarex gene conditionally decreases fitness in two ways: (1) it causes malT- but not malT+ lysogens to be at a selective disadvantage in competition with non-lysogens. (2) During adaptation to slow, glucose-limited chemostat growth from rapid, glucose-excess flask growth, expression of the lambdarex gene transiently decreases the growth rate when compared to the non-lysogen.

Bacteriophage lambda↗