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Biomedical subjects

D Duprez

Publications and source records attributed to D Duprez.

At least 127 records · Page 7Linked to original sources
PubMed1986

Effect of indoramin on finger circulation in patients with Raynaud disease.

The effect of indoramin was investigated on finger circulation in 20 patients with primary Raynaud disease. After placebo run-in, indoramin (50 mg t.i.d. per os) and placebo were given double-blind and in randomized order, each for 6 (protocol 1) and 3 weeks (protocol 2). No significant changes in blood pressure and heart rate were observed. Finger blood flow, measured with venous occlusion plethysmograph, increased significantly (p less than 0.025) with indoramin as compared with placebo, and local calculated resistance decreased when measured at room temperature (protocol 1). In protocol 2 flow was measured at the end of a 6-min contact with water temperature of 40, 30, 20, 10 and 5 degrees C, respectively. It was shown that the difference between indoramin and placebo was largest at high temperatures and was clearly decreased at lower temperatures. Thus, the present data objectively document that indoramin is capable of favorably influencing skin circulation, but this effect is less pronounced at lower temperatures.

Blood Pressure↗
PubMed1986

Vasodilator effects of enalapril in patients with arterial hypertension.

Although it has been recognized that enalapril lowers blood pressure by reducing the total peripheral vascular resistance, its direct effect on blood vessels is largely unknown. Little information is available about the influence of enalapril on the different vascular regions. Ten patients with moderate essential hypertension were treated with enalapril 20 mg daily in a double-blind, placebo controlled cross-over study for six weeks during each period. Blood pressure and heart rate were measured in supine, sitting and standing position. Venous capacity was derived from pressure volume curves plotted simultaneously at forearm and calf. Arterial blood flow at rest and during reactive hyperemia was measured at calf and finger by plethysmography. Enalapril increases venous capacity in upper and lower limbs in patients with moderate essential hypertension. Also, there is vasodilation of calf and finger arteries both at rest and during reactive hyperemia. Finger and calf arteries contribute to the decrease of the total peripheral vascular resistance during treatment with enalapril; thus, ACE inhibition is capable of correcting the increased peripheral resistance which often is the main cause of arterial hypertension.

Clinical Trials as Topic↗
PubMed1986

[Cervical screening and surveillance of the cervix uteri before the age of 20].

The authors record a sample of 2,234 adolescents who were aged 20 years or less and who had systematic cervical screening. This was carried out in a Social Service gynaecological department and the reason for it was mainly to research in the epidemiology. The authors have analysed the results of 870 cervical smears and 62 colposcopies. They found that in this young population there were 11% dysplastic smears; 59% viral type smears (condylomata or herpes); 11% mild or moderate dysplasias and 16% flat condylomata that were proven histologically. The authors review the recent literature and their results and the risk factors for cancer of the cervix in adolescents and demonstrate the value of early screening of this population.

Adolescent↗
PubMed1985

Peripheral vascular responses during stimulation of the low pressure receptors in man.

Several studies have been devoted to the cardiovascular responses to stimulation of low pressure receptors in animals. Yet, in man, the vascular participation in this reflex response is not fully documented. In the present work, the response of forearm and finger blood vessels was studied in a group of healthy subjects during stimulation of the low pressure receptors, using lower body negative pressure (LBNP) at -10, -20 and -40 mmHg. Blood flow was measured simultaneously at the forearm and the finger with an electrocardiogram (ECG)-triggered venous occlusion plethysmograph. Blood pressure remained unchanged at LBNP -10 and -20 mmHg, while there was a significant decrease of systolic and mean arterial blood pressure at LBNP -40 mmHg. Heart rate significantly increased at LBNP -20 and -40 mmHg, while no change in heart rate was seen at LBNP -10 mmHg. There was a significant decrease of blood flow at the forearm and a significant increase of the vascular resistance at LBNP -10, -20 and -40 mmHg. There were no changes in finger circulation. Thus, peripheral circulation is only partially involved in the cardiovascular response to stimulation of the low pressure receptors in men. There is a significant vasoconstriction of forearm blood vessels, occurring before any change in blood pressure and heart rate, while finger blood vessels do not participate in this reflex.

Blood Pressure↗
PubMed1979

[The narrow path].

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Abortion, Induced↗
PubMed1978

[Prostaglandins E2 and F2alpha in induction of labour, induced abortion and molar abortion. (70 case histories) (author's transl)].

The authors report on their experience using prostaglandins E2 and F2alpha in obstetrics. 70 cases are involved: 30 inductions of labour, 33 abortions and 7 hydatidiform moles. The results as far as induction of labour is concerned are encouraging (76.6 p 100 success), but in the doses used no better than those achieved with synthetic posterior-pituitary oxytocins. On the other hand, as far as abortions are concerned, prostaglandins, whether given intravenously, intra-amniotically or extra-amniotically, are the method of choice because they are practically free of danger in the second trimester of pregnancy (93.9 p. 100 success). Side effects are common but are usually not severe and do not interfere with the treatment.

Abortion, Induced↗
PubMedDate not supplied

Impaired microcirculation in heart failure.

The aim of the present study was to examine the nailfold capillary morphology and dynamics in treated chronic heart failure (CHF) in relation to parameters of left ventricular structure and function. Twenty patients with CHF class II according to the New York Heart Association underwent a capillaroscopic examination at the finger nailfold using a computerized videophotometric system (Capiflow) at rest and after 1 min arterial occlusion. Study parameters ere number, length and diameter of the capillaries as well as capillary blood velocity (CBV). Further experiments included echocardiography and determination of left ventricular ejection fraction by Tc scintigraphy. Nailfold capillaries in established CHF are enlarged and the CBV is dramatically decreased. The reactive hyperemic response to 1 min arterial occlusion is attenuated. CBV correlates positively with left ventricular ejection fraction (r = 0.61, p = 0.01) and inversely with left ventricular end-diastolic (r = -0.56, p = 0.04) and end-systolic (r = -0.69, p = 0.01) diameters. The time-to-peak flow after 1 min arterial occlusion is positively related (r = 0.68, p < 0.05) to the duration of CHF. Our data indicate that finger microcirculation in CHF deteriorates as a function of the severity and duration of heart failure.

Aged↗
PubMedDate not supplied

Circulatory changes in muscle and skin arteries in primary hypertension.

This review deals with circulatory adjustments occurring in the limb arteries of hypertensive patients. Measurements of regional blood flow are mandatory, because conclusions drawn from calculated total peripheral resistance often are not applicable to local vascular beds. Limb arteries, which can be followed by easy and noninvasive methods, often are the first choice for study of regional circulation. In this discussion, a few historic studies are cited first; next, the data available on skeletal muscle (forearm and calf) and skin (finger) circulation are reviewed, to show that flow through both muscle and skin is increased in mild and moderate hypertension, while there is a trend to lower values in more severe hypertension. Our own data are derived from 51 untreated patients showing mild to moderate hypertension, matched to 23 normotensive subjects. Flow is measured simultaneously with an ECG-triggered venous occlusion plethysmograph at calf and finger. At rest, calf and finger blood flows are significantly higher and calculated resistance is lower in hypertensive subjects; during reactive hyperemia, blood flow remains higher in hypertensive subjects but calculated resistance increases up to values that are higher, compared to normotensive control subjects; these data are compatible with structural changes in the vascular wall.

Arm↗
PubMedDate not supplied

[Multiple abortion].

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Abortion Applicants↗