[Herman Fischgold (1899-1982)].
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Biomedical subjects
Publications and source records attributed to D Doyon.
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Results of diagnostic ultrasonography in 29 patients with pancreatic duct dilatation were able to define the value of this procedure in the diagnosis of chronic pancreatitis and particularly cancer of the pancreas. Dilatation of the duct may in fact be the only ultrasonographic sign of a pancreatic lesion. It is now possible to study the pancreatic duct by ultrasonography, and this method of exploration should be employed whenever the pancreas has to be investigated.
Correlations between ultrasonographic and clinical and histological findings were studied in 74 patients presenting with echogenic gallbladder sludge. The majority of patients in whom bile examinations had been performed had either pus, blood, biliary sediment, or microcalculi in the bile, but precise identification of the nature of the sludge does not appear to be possible on ultrasonography. Calculi were present in the gallbladder in 39 p. cent of these patients, only 9 p. cent demonstrating the presence of sludge without established liver or biliary lesions. This ultrasonographic image appears, therefore, to be a clinically significant valid finding.
Percutaneous transluminal angioplasty was invented by Dotter, in 1964, for the treatment of atheromatous stenosis in inoperable patients. But it only became widely used since Gruntzig made it free from risk of major arterial wall damage by developing an inflatable balloon catheter. Trained vascular radiologists can now treat with little danger not only ilio-femoral, popliteal, renal, coronary or even subclavian stenoses, but also a number of local obstructions of leg arteries. The respective indications of angioplasty and vascular surgery are not yet well defined and must be discussed for each patient.
The authors have reviewed the experimental literature about the different agents used for endovascular embolization: clots, tissues, duramater, Gelfoam, oxydized cellulose, Ivalon, beads, microspheres, cyanoacrylates, silicone, barium. Each occlusive agent was studied in regard to its physical properties, injection methods, characteristics of obstruction, vascular reaction, and toxicity. The level and quality of obstruction obtained depend on many factors which are discussed.
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A case of a left inferior vena cava with prolongation into a hemiazygos vein is reported, in which the diagnosis was suspected after ultrasonography and confirmed by inferior cavography. Ultrasonographic signs were absence of a retrohepatic inferior vena cava, direct opening of the inferior hepatic veins into the right atrium, and the presence of a longitudinal vascular structure behind and on the left of the aorta, corresponding to the left inferior vena cava.
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During the last 4 years, 31 infants (ranging from 4 months and half to 15 years of age) were angiographied for different head and neck pathologies. 20 of them were embolized, among which 11 did not received additional treatment, and are still followed by the neuroradiologist. 45 superselectives arteriographies by femoral approach were performed, no morbidity nor mortality was noted. The authors emphasize the need to pay attention to the advantages of this technique when realized in specialised centers. The vascular characters of a lesion is not necessary nor a sufficient sign to make it a good indication for an embolization procedure. Finally, the neuroradiologist can be considered as a diagnostic and therapeutic specialist, the most competent to indicate (or contra indicate) an endovascular approach in a given situation.
Therapeutic embolization by means of autologous clots or fragments of gelatin sponge was carried out in 11 patients suffering from renal haemorrhage of traumatic origin (5 needle biopsies, 3 surgical operations, 2 external traumas, 1 penetrating wound). Arterio-venous fistulae were present in 6 cases and arterial lesions in 5. Performed with a fine catheter, embolization was highly selective for the segmental arteries involved. The clinical symptoms disappeared within less than 12 hours in three patients, within 2 to 4 days in five and within 15 days in one. In two patients haematuria was only temporarily arrested ; a second embolization could be performed in one of these, but nephrectomy was required in the other.
Four patients (aged 5, 8, 14, and 51 years at initial manifestation) with isolated eosinophilic granulomas of the orbital frontal bone displayed short symptomatic periods (two weeks to three months) and some combination of erythema of the lids, a soft, palpable anterior orbital mass, periorbital pain, and osteolytic bone lesions on roentgenography. The bone lesions roentgenographically exhibited irregular, serrated, and sclerotic margins, distinguishing them from the more oval appearance of dermoid cysts. Electron microscopy performed in one case disclosed the presence of Langerhans' granules in the cytoplasm of the histiocytes, indicating that the orbital disease is a mild form of "histiocytosis X" and a benign proliferation of a specific kind of histiocyte--the Langerhans' cell. On follow-up (two to 20 years), after incomplete curettage of two lesions coupled with low doses of postoperative radiotherapy, there was reconstitution of the bone defects, whereas more extensive surgery performed on the other two patients resulted in permanent but subclinical bone defects.
A bipolar electrode for transcatheter electrocoagulation with alternating current is described. This electrode avoids the problem of variation of the electric impedance of the monopolar electrode/ground plate system. It allows quick, safe, and reliable endovascular occlusion of vessels.
Portal vein and its two branches were evaluated by ultrasound in 12 children (14 months to eight years) with portal cavernomas; the cavernomas appeared idiopathic (five cases) or were secondary either to a catherization of umbilical vein in the neonatal period (six cases) or to trauma (one case). Angiographic confirmation of cavernoma was obtained in all patients. Twelve patients with intrahepatic portal hypertension were used as controls. The following abnormal patterns were observed: (1) absence of normal portal vein; (2) absence of normal portal division; (3) tortuous, small and irregular appearance and/or abnormal sagittal division of the venous system; (4) presence of small linear echoes dotting the portal vein; (5) presence of small linear echoes dotting the porta hepatis area. Ultrasonogram was normal in the 12 controls. Thus, ultrasound appears to be a procedure of choice in the evaluation of portal cavernomas, permitting postponement of invasive angiographic examination until surgical treatment is anticipated.
The principles underlying the use of embolisation in the management of tumours and vascular malformations of the head and neck are reviewed. The percutaneous angiographic technique is employed to embolise the lesion, producing the effects of haemostasis, reduction of tissue mass and relief of pain. Specific clinical applications are discussed with illustrative examples.
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