[Carcinosarcoma-pseudosarcoma of the oesophagus. Review of the literature, classification, new histogenetic theories. (Report of three cases) (author's transl)].
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Biomedical subjects
Publications and source records attributed to D Douvin.
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Morphological study of the ovular membranes showing that under the amnion, until term, there persists perfectly live and active chorial cytotrophoblast covered by a well vascularised and developed parietal decidua. Under the electron microscopy, the apical pole of the amniotic cells as well as their intercellular space are bordered by microvilli. Their basal pole has squat pedicels. The chorion which supports the amnion is avascular. The surface of the cytotrophoblast opposite the chorio-amnion is raised by numerous protuberances in the form of pedicels. The trophoblast is also furrowed by intercellular canals bordered by microvilli and reinforced by desmosomes. Two cellular appearances may be distinguished in the trophoblast: elements similar to the syncytial type with the characteristics of steroid cells and elements of a Langhans type which may play a role in protein synthesis. The decidual cells, in a quinconcial perivascular arrangement, are rich in pinocytotic vesicles. Thus whilst it is undeniable that the foetus plays a certain role in the dynamics of the amniotic fluid by swallowing and urinary excretion, these phenomena are minimal in relation to exchanges through the ovular membranes. Transamniotic passage is the first stage in movement of the fluid. The chorion, by virtue of its plexiform, areolar structure forms the next stop. From the chorion, the circulation continues through the intercellular canals of the trophoblast and the amniotic fluid is thus brought into the well vascularised parietal decidua. In addition to this extracellular circulation, the authors fell that there exists an intracellular passage by uptake and secretion, as evidenced by the high degree of pinocytosis within the cells.
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Crohn's disease with a predominantly pseudopolypoid presentation is a rare form. The inflammatory polyps are of highly variable topography. They may be located in the colon and the ileum. There are diffuse and localised forms. This pseudopolypoid form of Crohn's disease poses, in addition to diagnostic problems, pathogenic questions, integrating these findings within the context of nonspecific reactions of the colon, secondary to an ulcerating process which may be specific.
Pseudo-membranous colitis may develop after treatment with antibiotics, and in particular lincomycin a, d clindamycin. A "thumbprint" appearance of lacunae 2 to 4 mm in diameter, in substraction in relation to the wall of the colon, diffuse involvement of the colon and the regression of these signs when antibiotics are stopped are the typical radiological signs of this disorder.
Four cases of cysts or tumours developing from embryological remnants in the peri-ano-rectal space are reported. The authors propose for these rare lesions a coherent and simplified classification in two main groups: teratomas on the one hand, developmental cysts on the other hand. The various methods of diagnosis are studied. The precise diagnosis of a congenital cyst can only be made by pathological examination of the specimen after surgical removable. Any rapid local change implied malignant degeneration. Such a risk suggests immediate removal of any known ano-rectal cyst or tumour. The route of approach is usually perineal. Kraske's position gives good access to the retro-ano-rectal space. Possible pelvic spread of these lesions sometimes requires the use of the abdominal approach, either straight away or secondarily when total removal is impossible by the perineal route alone.
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Intimate fusion of the renal and suprarenal parenchyma, associated with cystic lesions in the zone of tissue juxtaposition, constitutes a form of suprarenal-renal dysgenesis for which the name "dystopia" has been suggested. The distinction must be made from suprarenal-renal adhesions in which a connective tissue barrier between the two parenchymas persists. In this present case, the malformation gave rise to a pseudo-tumoral syndrome of rapid appearance in association with a haemorrhage. Removal of the kidney cannot be avoided in view of the absence of any plane of cleavage with the suprarenal when the suprarenal tumour is removed.
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In a general review of the different varieties of the intestinal polyposes, emphasis is laid upon the main three types of the so-called "genetic polyposes" (juvenile polyposis, Peutz-Jeghers syndrome, and adenomatous polyposis) because of their peculiar interest concerning the pathological diagnosis, prognosis and genetic background. A correct histological diagnosis is of the utmost importance before an appropriated treatment can be initiated.
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