Search PubMed⌕ Search

Biomedical subjects

D Doniach

Publications and source records attributed to D Doniach.

At least 109 records · Page 6Linked to original sources
PubMed1973

Types of 'reticulin' antibodies detected in human sera by immunofluorescence.

Reticulin antibodies have been classified by immunofluorescence into five types reacting with distinct antigens of intra- and extracellular components in mesenchyme. Two types of fibrillar antigens can be distinguished on the basis of the staining patterns, anatomical distribution, and species specificity. A third antibody reacts with either small fibres, amorphous proteins, or mucopolysaccharides lining the hepatic sinusoids (ground substance antigens). In addition, at least two kinds of intrasinusoidal cells show cytoplasmic fluorescence, ie, Kupffer cells and glass-adherent, blood-borne cells antigenically related to peritoneal macrophages. Some sera may contain antibodies reacting with sinusoidal endothelial cells though this has not yet been proven. It has been confirmed that all these distinct antibodies related to reticulin antigens are most frequent in dermatitis herpetiformis and coeliac disease, but they are also found with increased frequency in chronic heroin addicts and in rheumatoid and Sjögren's syndromes. About 5% of normal individuals had such antibodies and no significant increase could be demonstrated in autoimmune disorders or in liver cirrhosis. The antibodies appear to be stimulated by bacterial or nutritional antigens and are likely to represent anamnestic responses rather than direct cross reactions with a multiplicity of foreign antigens.

Animals↗
PubMed1972

Chronic liver disease and mitochondrial antibodies: a family study.

Two sisters had primary biliary disease and associated autoimmune thyroiditis with high titres of mitochondrial and other autoantibodies. Their deceased mother possibly suffered from similar disorders. In the same family two brothers had multiple autoimmune reactions, including mitochondrial antibodies, but liver function tests gave normal results. Ten other close relatives were investigated. Australia antigen was not found in the proband or her relatives.

Adult↗