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D Djawari

Publications and source records attributed to D Djawari.

At least 55 records · Page 3Linked to original sources
PubMed1982

[Immunological investigations in recurrent herpes simplex (author's transl)].

Various immunological parameters were studied in 49 patients suffering from recurrent herpes simplex and in 100 healthy sex- and age-matched individuals. The study included determination of immunoglobulins in serum, classification and PHA-stimulation of peripheral lymphocytes as well as testing different granulocyte functions in vitro. We found a moderately reduced number of T-lymphocytes in 20 patients and a strikingly decreased rate of PHA-induced lymphocyte transformation in 30 patients. A slight impairment of chemotactic activity and markedly reduced capacity of killing Candida albicans blastospores by granulocytes was also found. These results point to an immunological alteration in patients with recurrent herpes simplex.

Adult↗
PubMed1982

Lytic effect of cytotoxic lymphocytes on oral epithelial cells in Behçet's disease.

The effect of blood lymphocytes on syngeneic oral epithelial cells was studied in twelve patients with Behçet's disease (BD) and twenty-one patients with recurrent aphthous ulcers (RAU). The control group consisted of twenty-five patients with non-aphthous skin disease and eight healthy individuals. Primary cell lines obtained from oral mucosa by suction blistering and subsequent enzymatic dissociation were used as target cells. Using a modified 51chromium release macro-assay, a significant lytic effect due to antibody-independent lymphocytotoxicity could be demonstrated in patients with BD, but no significant lysis of target cells was found in the RAU patients compared with the control group. These results provide further evidence that antibody-independent lymphocytotoxicity may play an important role in oral ulceration in BD.

Adolescent↗
PubMed1982

Impairment of some microphage functions in recurrent herpes simplex.

Chemotactic, phagocytic and intracellular killing activities of polymorphonuclear leukocytes (PMNL) were investigated in vitro in 49 patients suffering from recurrent bouts of herpes simplex. A slight impairment of chemotactic activity and a markedly reduced capacity of killing Candida albicans blastospores were revealed. Phagocytic capacity and NADH-dependent oxidase activity of PMNL proved to be normal. The results point to an alteration of some PMNL functions in these patients.

Adult↗
PubMed1982

[Papulous mucinosis in lupus erythematosus integumentalis].

Report on a 55-year-old female patient developing skin-colored papules on her back and shoulders after sun exposure and later on typical lupus erythematosus (LE) lesions. During therapy with chloroquine there was regression of LE and annular extension of peripherally developed mucinous papules which did not vanish entirely. Histochemically, dense reticular deposits of metachromatic mucinous material was found in the mid cutis.

Female↗
PubMed1981

[Oral aphthae].

Explore the source record for details and available documents.

Adult↗
PubMed1981

Enhancement of granulocyte chemotaxis in Behcet's disease.

The humoral and cellular immune status, the cutaneous pathergy, PMNL in vitro function tests as well as clinical and general laboratory examination were performed and evaluated on ten patients suffering from Behcet's disease (BD) and ten other patients with benign recurrent aphthosis (RA). The same set of in vitro tests (except PMNL exposure to solutions of copper sulfate or DDT) was carried out on a control group consisting of more than 100 healthy male and female individuals of various ages. Apart from general signs of inflammatory activity (leukocytosis, elevation of ESR, increased IgG serum levels), cutaneous pathergy to mild local highly injuries and marked enhancement of PMNL chemotaxis proved to be highly significant symptoms in acute phases of BD in contrast to benign RA. Both symptoms, in particular the hyperchemotaxis of PMNL, can be regarded as valuable diagnostic means in the early detection of beginning or atypical BD.

Adolescent↗
PubMed1981

Immune phenomena in patients with pustular bacterid.

In 20 patients with histologically confirmed pustular bacterid of immunological status was checked including lymphocyte and granulocyte components of the cellular immune system as well as HLA typing. For comparison the same investigations were carried out in 20 healthy controls. In contrast to the controls, in the group of patients the chemotactic activity of polymorphonuclear leukocytes as well as their ability to engulf either vital or heat-inactivated Candida albicans cells was found to be slightly impaired (p less than or equal to 0.01 and 0.05, respectively). Killing of C. albicans cells by polymorphonuclear leukocytes were strikingly impaired (p less than or equal to 0.001). NADPH-dependent oxidase activity, however, was found to be normal. Impairment of chemotaxis and killing activity could not be substantiated in AB pool serum, thus a serum-dependent disorder of granulocyte function has to be assumed. Lymphocyte response to phytohemagglutinin was reduced in all patients, whereas intracutaneous test reactivity to microbial antigens was normal. T and B cell counts in peripheral blood were within normal range. HLA typing revealed a significantly increased prevalence rate of HLA-B14 as compared with the control group and other patients.

Adult↗
PubMed1980

[Non-infectious oral aphthous disorders. 2. Behçet's syndrome (malignant aphthosis)].

Behçet's (Behçet-Touraine's resp.) disease is a very serious systemic vasculitis exhibiting the clinical features of simultaneously or successively recurrent oral aphthosis, genital lesions and ophthalmitis (mainly of uveitis type). During relapsing acute phases of generalisation multifocal visceral, arthritic and/or neurological manifestations with life-threatening complications may develop. The disease which in some geographic areas (Japan, Near East) is observed with rather high prevalence rates, is also assumed to occur in Central Europe more frequently as being diagnosed so far. As to early recognition, the recurrent oral aphthosis spread in the entire oro-pharynx ("malignant aphthosis") is of importance. The present view of aetiopathogenesis deals with an abnormal increase of circulating immune complexes (mainly IgG complexes) against mucosal and/or microbial antigens, which accumulate in both small and larger blood vessels elicidating a severe immunocomplex vasculitis with necrotising tissue damage. For therapeutic management systemic high dose treatment with corticosteroids including immunosuppressive drugs is mandatory.

Adrenal Cortex Hormones↗
PubMed1980

[Non-infective oral aphthous diseases. 1. Benign recurrent aphthoses].

Recurrent oral aphthosis, a very frequent disease, is encountered most often in predisposed individuals in their second to third decade, and found twice as often in females than in males. Not only genetic but a variety of different other factors participate in the manifestation of the disease, many of them controversial as far as their significance is concerned. Polymorphonuclear leukocyte (microphage) function is unimpaired. HLA-studies in affected families indicate a genetic disposition.

Adolescent↗
PubMed1980

[The function of microphages in chronic recurrent pyodermias].

Polymorphonuclear leukocyte (PMNL) function tests were performed in 20 patients suffering from chronic recurrent pyogenic skin infections and, in addition, in 20 healthy individuals. As for in vitro tests, investigations of chemotaxis, intracellular killing and NADH dependent oxidase activity were included. Compared to the control group, a marked impairment of chemotaxis but totally normal microphage motility, a significantly decreased intracellular killing of ingested microorganisms by these phagocytes and an almost phagocytosis of viable and heat-inactivated Candida albicans cells could be detected in the examined patients. These results once again demonstrate the extraordinary importance of PMNL in the body's primary defense mechanisms.

Adolescent↗
PubMed1980

[Cellular immune status and microphage function in Behçet's disease].

Besides routine clinical and laboratory investigations, several lymphocyte and polymorphonuclear leukocyte function tests were performed in 10 patients with Behçet's disease (1 of Turkish and 9 of German descent, 5 of them male and 5 female). No true abnormality could be detected in both number of T- and B-cells as well as in T-cell response to PHA-stimulation. In contrast, there was a significant enhancement of microphage migration and chemotaxis in all of our patients compared with a large control group of healthy individuals. The very same investigations carried out in 10 patients suffering from benign recurrent aphthosis (most of them of Mikulicz's type) showed no difference to our controls. And above all, there was no increase of chemotactic microphage function. Therefore, assessment of microphage chemotaxis has become an important investigative procedure for in-vitro testing of atypical or low-grade manifestations of Behçet's disease. Abnormal polymorphonuclear leukocyte chemotaxis indeed give some explanation of non-specific cutaneous pathergy as a phenomenon and, no doubt, should be superior in diagnostic reliability as abnormal chemotaxis can even be detected in patients suffering from faint relapses of Behçet's disease.

Adolescent↗
PubMed1980

Recurrent chronic pyoderma with cellular immunodeficiency. Successful therapy by levamisole.

In a 21-year-old male patient afflicted with widespread recurrent pyoderma resistent to antimicrobial therapy since 3 years, a deficient state of cellular immunity including dysfunctions of both microphages and T lymphocytes was disclosed. After 6 weeks of systemic treatment with levamisole all lesions cleared completely, whereas appropriate long-term antibiotic therapy previously administered had failed to succeed. The immunological parameters, as far as being reexamined, also returned to normal levels during levamisole therapy.

Adult↗
PubMed1980

Altered cellular immunity in Werner's syndrome.

A cellular immunodeficiency was revealed in a 39-year-old female patient suffering from Werner's syndrome. Relevant findings were negative intracutaneous tests to candidin, trichophytin, tuberculin and bacterial antigens, reduced lymphocyte response to PHA, and impaired intracellular killing of Candida albicans by granulocytes. The inclination of patients suffering from Werner's syndrome to develop neoplasms may be related to this immunodeficiency.

Adult↗
PubMed1980

Disorder of cellular immunity in pemphigus vegetans.

In an untreated 26-year-old female patient suffering from Neumann's pemphigus vegetans for 8 months (with neither preceding thymoma nor myasthenia gravis), several in vivo and in vitro phenomena of immunodeficiency involving both T and B cell system were disclosed. A diagnosis of defective immune state was established on the basis of the low IgG-serum level (though pemphigus antibodies were present), reduced T cell count in blood, weak PHA stimulation of lymphocytes, lack of skin reactivity to recall antigens and to most other bacterial antigens tested. Impaired chemotaxis and a deficient intracellular killing of Candida albicans by PMNL were also found. The conclusion is drawn that a combined disorder of both the B and T cell system is involved in the etiology of pemphigus vegetans, even when thymoma is ruled out.

Adult↗