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Biomedical subjects

D Dimitrov

Publications and source records attributed to D Dimitrov.

At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

Atrial natriuretic factor infusion following acute renal ischemia in anesthetized dogs.

Atrial natriuretic factor (ANF) has been shown to be effective in reversing renal functional impairments following renal ischemia. We studied the effects of a nonhypotensive intravenous ANF infusion (100 ng/min x kgBW, 60 min) after 90 min unilateral renal arterial occlusion in anesthetized dogs with an intact contralateral kidney. ANF plasma levels remained unchanged in controls (group 1) and increased in ANF-infused animals (group 2) from 22 +/- 3 to 552 +/- 124 pg/ml. Blood pressure increased in both groups during renal ischemia, but returned to control values in group 2 when ANF infusion was started. Plasma vasopressin did not change in group 1, but increased in group 2 (0.77 +/- 0.29 vs. 1.10 +/- 0.49 pg/ml) after terminating ANF infusion. The postischemic fall in creatinine clearance (CCr), filtration fraction (FF) and renal blood flow (RBF) was prevented by infusion of ANF (CCr: group 1, 0.16 +/- 0.05 vs. group 2, 1.01 +/- 0.25 ml/min x kgBW; FF: group 1, 4.0 +/- 1.6 vs group 2, 14.1 +/- 4.1%; RBF: group 1, 6.0 +/- 1.2 vs. group 2, 9.2 +/- 1.6 ml/min x kgBW); however, the effects were limited to the time of infusion and the postischemic increase in urinary excretion of the proximal tubular enzyme N-acetyl-beta-D-glucosaminidase (NAG; group 1, 317.7 +/- 163.6 vs. group 2, 672.4 +/- 245.7 microU/min x kgBW) was not improved by ANF. Our data suggest that infusion of ANF transiently reverses postischemic renal impairment. However, the failure to demonstrate a sustained postischemic improvement of renal functional parameters and to ameliorate massive NAG excretion casts doubt on the benefit of ANF infusion in preventing cellular damage.

Acetylglucosaminidase↗
PubMedDate not supplied

Vibration disease: plasma electrolytes and trace elements.

102 patients with vibration disease (mean age 46 +/- 7, length of service in different jobs using vibration tools 17 +/- 7 years) were studied. Plasma electrolytes and trace elements (sodium, potassium, calcium, magnesium, phosphorus, chloride, iron, copper, zinc, cobalt and manganese) and plasma osmolality were investigated, as well as some specific tests indicative of vibration exposure--cold provocation test, vibration sense, thermoasymmetry (left/right hand), skin electric resistance and hand and finger blood flow (Doppler-ultrasound sonometry). In a large number of patients increased values for the following variables were found--magnesium in 43%, zinc in 45%, cobalt in 57%, manganese in 70% and plasma osmolality in 66%. It is suggested that vibration affects mineral metabolism. However, these disturbances in mineral metabolism are secondary to other pathological changes in the body.

Adult↗
PubMedDate not supplied

Analysis of the drugs, applied for the treatment of the patients, hospitalized in a urological department, by pharmacological groups.

The analysis of the drugs, applied for the treatment of the hospitalized patients in a urological department shows that the application of the drugs in a urological department gives the opportunity to stop the process of the development of the disease and to avoid the hospitalization of the patients. The research shows the different pharmacological groups of drugs that are applied and also the expenses that are made for the treatment of the patients.

Drug Utilization↗
PubMedDate not supplied

Pharmaco-economical analysis of the treatment with antibiotics in a surgery department.

The fulfillment of a pharmaco-economical analysis of the treatment with antibiotics is an important task in the conditions of a transition period, that is currently in Bulgaria. The great problem with the insufficient financial sources prevents the supply with drugs, medical supply and technology. This analysis is a kind of an auxiliary source in the process of managing in the sphere of the health policy and in particular--in the sphere of the pharmacy.

Adult↗