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Biomedical subjects

D Deutsch

Publications and source records attributed to D Deutsch.

At least 109 records · Page 6Linked to original sources
PubMed1975

Musicalillusions.

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Auditory Perception↗
PubMed1975

Auditory memory.

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Auditory Perception↗
PubMed1972

Mapping of interactions in the pitch memory store.

A technique obtaining a precise mapping of interactive effects in the pitch memory store is described. Subjects were required to compare two tones for pitch when these were separated by a 5-second interval during which six other tones were played. In the second serial position of the intervening sequence there was placed a tone whose pitch bore a critical relationship to the pitch of the first test tone. When the critical intervening tone was identical in pitch to the first test tone, memory facilitation was produced. As the separation in pitch between these two tones increased, errors rose progressively, peaked at a separation of 2/3 tone, and declined roughly to baseline at a whole tone separation. It is concluded that the pitch memory store is arranged logarithmically in a highly ordered and specific fashion.

Computers↗
PubMed1970

Tones and numbers: specificity of interference in immediate memory.

Recognition of the pitch of a tone was severely disrupted by the incorporation of six other tones during a 5-second retention interval, even though the intervening tones could be ignored. However, the requirement to recall six numbers spoken at equal loudness during the identical retention interval produced only a minimum decrement in the same pitch-recognition task. Further, the requirement to remember the tone produced no decrement in recall of the numbers. It is concluded that immediate memory for pitch is subject to a large interference effect which is highly specific in nature and which is not due to some limitation in general short-term memory capacity or to a distraction of attention.

Humans↗
PubMedDate not supplied

Biochemical characterization of matrix vesicles from bone and cartilage.

Extracellular matrix vesicles from bone and epiphyseal cartilage of femur and tibia of rats were isolated by collagenase digestion (crude vesicles) and further purified by sucrose gradient centrifugation. Fractions containing cells and membranes were also isolated from the two tissues. The alkaline and acid phosphatase and ATPase activities, as well as protein content of all fractions including crude and purified matrix vesicles, were assayed. The crude vesicles from both tissues demonstrated a high alkaline phosphatase specific activity (5-20 times higher than in the cell fraction). The total enzyme activities and protein content were significantly higher in all fractions from cartilage than those from bone. A major peak of alkaline phosphatase activity and protein content was obtained following the sucrose gradient centrifugation. The position of this peak was similar for both tissues. The specific activity of alkaline phosphatase of purified matrix vesicles was significantly higher in bone than in cartilage. The phosphatase activities from cartilage and bone showed a similar pH dependence and a similar response to metal ions. Of the metal ions tested (Na+, Mg2+, Zn2+, and Ca2+) only Zn2+ (at 5 mM concentration) inhibited significantly the alkaline phosphatase activity of purified matrix vesicles. The electrophoretic profile of purified matrix vesicles showed eight major protein bands common for both tissues. In addition, cartilage vesicles appeared to possess two peptides not found in bone.

Acid Phosphatase↗
PubMedDate not supplied

Characterization of murine autologous salivary gland graft cells: a model for use with an artificial salivary gland.

The purpose of this study was to examine the growth and key functional abilities of primary cultures of salivary epithelial cells toward developing an artificial salivary gland. Cultures of epithelial cells originating from submandibular glands of BALB/c mice were established. Parenchymal cells were isolated by a Percoll gradient technique and thereafter seeded on irradiated NIH 3T3 fibroblasts serving as a feeder layer. The isolated cells were termed autologous salivary gland epithelial (ASGE) cells and could be cultivated for at least five passages (time limit of experiments). ASGE cells presented the typical organizational behavior of epithelial cells and electron microscopy, as well as immunostaining for cytokeratins, confirmed their epithelial origin. Furthermore, measurements of transepithelial resistance and water permeability indicated the ability of the ASGE cells to form a functional epithelial barrier. This study suggests that primary salivary epithelial cells can be obtained that exhibit critical characteristics needed for use with an artificial secretory device.

Animals↗