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Biomedical subjects

D Denton

Publications and source records attributed to D Denton.

45 records · Page 3Linked to original sources
PubMedDate not supplied

Salivary elimination of cyclophosphamide in man.

A total of 25 plasma and saliva samples were obtained from three hospital inpatients upon intravenous short-time infusion of cyclophosphamide; total doses infused ranged from 5.3 to 13.3 mg/kg. Despite interindividual variations, a correlation was found for plasma-to-saliva ratio of 1.61 +/- 0.53 (S.D.). Our Saliva-to-plasma ratio of 0.62 is in agreement with a recently reported ratio of 0.77. The ratio stayed constant throughout the observation period (0.5 to 8.4 hours), indicating that the noninvasive method of saliva sampling seems to be a useful approach in cyclophosphamide drug concentration monitoring in patients.

Adult↗
PubMedDate not supplied

A survey of obstetric malpractice in western frontier areas.

A mail survey of 524 physicians in the frontier areas of Colorado, Montana, North Dakota, South Dakota, Utah, and Wyoming, and the rural areas of Utah was conducted; 286 valid responses were collected (54.6%). Of the respondents, 97% had at some time practiced obstetrics, and, of those now practicing obstetrics, 39% reported they would discontinue providing obstetrical care within the next year. Of those stopping, 95% indicated that malpractice was a major factor in their decision. Of the respondents, 74% indicated that access to obstetric services would be a problem in their areas if they discontinued this type of care.

Humans↗