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Biomedical subjects

D Dekaris

Publications and source records attributed to D Dekaris.

50 records · Page 3Linked to original sources
PubMed1968

Macrophage spreading: inhibition in delayed hypersensitivity.

The capacity of peritoneal macrophages to spread was studied with cells of mice infected with Listeria monocytogenes and with cells of guinea pigs sensitized with BCG (bacille Calmette Guérin) vaccine or immunized with ovalbumin. In macrophages taken from animals having delayed hypersensitivity, this ability was markedly decreased by the presence of specific antigen for less than 1 hour. Such an effect was not observed in guinea pigs having only circulating antibodies.

Animals↗
PubMedDate not supplied

Psychological condition hormone levels in war trauma.

Psychological and hormonal responses to various degrees of war-related traumatic experience were analysed in 91 subjects. Their psychological responses (psychosomatic, personality traits, etc.) were evaluated by the COR-NEX2 test. Based on test results, the subjects were classified into three groups: G1 = normal, G2 = moderate, and G3 = severe response. The distribution of subjects in the three groups was related to the intensity and duration of stress that they had been exposed to. Serum levels of cortisol, prolactin, beta-endorphin, thyroxin and triiodothyronine were analysed in all subjects. The levels of cortisol and prolactin were significantly decreased in subjects expressing a severe psychological response, while the level of prolactin correlated with COR-NEX2 test scores. Although relations to other intervening variables are to be investigated, our results indicated that endocrine changes, following trauma, were not random, but rather related to stress-induced psychological responses, and not to trauma per se.

Adolescent↗
PubMedDate not supplied

Immune, endocrine, and psychological responses in civilians displaced by war.

OBJECTIVES: The objectives of this study were to assess the influence of trauma caused by forced expulsion from home in a war-ravaged region on the psychological, hormonal, and immune responses in displaced persons and to analyze the relationships between psychometric, hormonal, and immunologic variables. METHODS: Participants were 20 displaced and 14 control women. Psychosomatic response was evaluated using the COR-NEX2 test. Serum concentrations of cortisol, prolactin, endorphin, thyroxine, and triiodothyronine were measured by radioimmunoassay. Immunophenotyping and lymphocyte proliferation were determined by flow cytometry, and phagocyte functions (i.e., ingestion and antibody-dependent cytotoxicity) against 51Cr-labeled sheep red blood cells were assessed through radioactivity uptake and release, respectively. RESULTS: In comparison with control women, displaced women had higher COR-NEX2 test scores; higher serum cortisol, prolactin, and endorphin levels; an increase in activated phenotype within all three measured cell populations (i.e., B, T, and natural killer cells); as well as an enhanced proportion of proliferating lymphocytes in freshly isolated samples. However, the phytohemagglutinin-stimulated proliferative response, estimated as the stimulation index, was lower in displaced women. A complex pattern of relations between psychological, hormonal, and immune responses was observed. CONCLUSIONS: Chronic psychological stress elicited multiple, predominantly stimulatory influences on immune functions.

Adolescent↗
PubMedDate not supplied

[Characteristics of immunoreactivity in neonates and young children. Review of the literature].

Newborns and infants are particularly susceptible to infections, and this appears to be due to deficient immuneresponsiveness. The survey of the pertaining literature (95 references) reveals the particularities of newborns' and infants' immune responses. After the brief survey of basic immunological terms, innate (natural) and acquired (specific), systemic and local (regional) immune responses are described. Characteristics of cellular [leukocytes, polymorphonuclears, neutrophils, eosinophils, mast cells, monocytes, macrophages, natural killer (NK-) cells] and humoral (complement system, fibronectin, C-reactive protein) components of innate immunity are surveyed. Follows the analysis of cellular and humoral participants in specific immune responses: antigen presenting cells (macrophages, dendritic cells), B cells (immunoglobulins), T cells (TCR-1 T cells, TCR-2 T cells). Finally, the characteristics of local immunity are described. The presented overview of the immune responses reveals a partial immune system's immaturity (maturational deficiency) in newborns and infants.

Antibody Formation↗