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Biomedical subjects

D Declerck

Publications and source records attributed to D Declerck.

53 records · Page 3Linked to original sources
PubMed1995

[Oral hygiene of handicapped subjects in Flanders].

As part of an epidemiology survey within the population of handicapped 12-year old in Flanders this article describes several parameters related to oral health. On the average, it became obvious that oral hygiene had to be seriously increased. The presence of plaque and calculus is very typical for types 1, 2, 4 and 8. In addition, it is most striking to conclude that groups where a maximum of self-handiness is expected, do not score any better. The application of chemical controlling agents and the use of fluoride supplements is found extremely low. Finally, a lack was found, with respect to adequate oral hygiene instructions. There is a real need for in-service training programs for educators as well as for parents.

Belgium↗
PubMed1995

[Status of the teeth and degree of care in handicapped in Flanders].

In general, handicapped 12-year old do not show statistical relevant differences with non-handicapped age-matched children in Flanders regarding general caries prevalence, caries distribution and total caries experience. However, important differences were found for the restorative index showing a higher caries treatment need in handicapped children. When the results were analysed according to the type of handicapping condition, it was seen that children with borderline and mild mental handicap and children with speech-, language and/or learning difficulties show the most unfavorable picture. They have a high caries prevalence and caries experience and a low restorative index. Additional analysis of the results can throw some light on the presence of additional caries risk indicators and contributing caries risk factors.

Belgium↗
PubMed1994

[Iatrogenic diffuse interstitial pneumonia linked to 5-aminosalicylate].

Iatrogenic pneumonias to sulphasalazine are most usually seen during the course of a haemorrhagic proctocolitis (RCH). We report a case in which a young woman was treated with 5-aminosalicylate (Pentasa) and prednisolone during an exacerbation of RCH. After 3 months of treatment the steroid therapy was stopped and the Pentasa was continued at the same dose (3 g per day). She presented with increasing dyspnoea on effort. Clinical examination was normal but a CT scan of the chest showed interstitial micro nodules; there was also a restrictive ventilatory disorder, hypoxaemia on effort and an alveolar eosinophilia (1.8%) The clinical progress, respiratory and blood gases all improved rapidly after stopping the Pentasa with the disappearance of the interstitial nodule over 5 months, suggesting that the role of the Pentasa was causal in the genesis of the pneumonia.

Aminosalicylic Acids↗
PubMed1992

[Oral problems and approach to dental care in case of diabetes mellitus].

Diabetic patients often present oral symptoms and complaints at the moment of diagnosis of their disease. Recurrence of these symptoms is possible in periods of poor metabolic control. Long term complications of the disease are noticed at the level of the oral cavity. Dentists can contribute to early recognition of oral manifestations. A careful dental follow-up of these patients is essential in order to reduce the incidence and severity of long term oral complications (advanced periodontal disease, ...) This article reviews the general and oral implications of diabetes mellitus and discusses the results of a clinical study regarding the orodental condition and oral preventive behaviour of children with diabetes. Practical guidelines for the dental care of patients with diabetes are outlined.

Child↗
PubMed1992

[Dental status and dental preventive behavior in Flanders].

Socio-economic factors are important parameters for dental health status and preventive behavior. In an epidemiologic survey of +/- 8000 5- and 12-year old schoolchildren in Flanders significant differences in dental attendance, brushing habits and caries prevalence were found between 12-year old boys and girls. Ethnic differences were pronounced. Dental attendance and brushing frequency were lower in non-West-European children. These children showed a higher caries attack rate at the age of 5 but in 12-year olds the opposite was noted. Interprovincial differences should probably be attributed to differences in social levels.

Belgium↗
PubMed1992

[Epidemiological study of caries prevalence in 5-and-12-year-old school children in Flanders].

A caries prevalence survey was carried out among twelve and five-year-old school children in Flanders (Belgium). The aim of the study was an evaluation of the education, prevention and treatment programme organised by the Flemish Working Group on Oral Prevention. The survey covered 3600 5-year old children and as many 12-year old adolescents, selected at random in the five Dutch-speaking provinces of Belgium. Concerning the caries experience of 5-year old children, we noticed a small dmft of 1.65 and a percentage of caries-free of 60%. Regarding the results for the 12-year olds, we recorded a DMFT of 2.72 and 25% caries-free adolescents. Children from non West-European origin scored much higher in dmft but showed a remarkably lower DMFT-index. We can suggest that an increased attention remains necessary for risk groups such as children with a high caries susceptibility, young immigrants and low income families. The dental health education in schools should be kept on-going and even be extended towards adolescents. Because we remarked a very low dental attendance pattern among young children, we really need to convince parents of the importance of early visits to the dentist. We believe that epidemiology is the only basis for a sound and evident prevention strategy.

Belgium↗
PubMed1991

[Dental care for patients being treated with oral anticoagulants. Prevention of hemorrhagic complications].

The oral management of patients receiving oral anticoagulants is controversial, especially concerning oral surgical procedures. The clinician has to balance the risk of reducing or stopping the medication with that of triggering bleeding complications. For each individual patient and for each dental intervention, two important factors should be evaluated and balanced: the risk for bleeding complications represented by the dental intervention and the medical risk for the patient in case of interruption of the anticoagulant therapy. Practical instructions for the different types of dental interventions and medical risk categories are proposed.

Anticoagulants↗
PubMed1989

Investigation of the ability of newer beta-lactam antibiotics to select resistant mutants from Serratia marcescens after mutagenesis with nitrosoguanidine.

Resistant mutants could easily be selected from a nitrosoguanidine-treated culture of Serratia marcescens with piperacillin, cefotaxime, cefoxitin, cefotetan, latamoxef (moxalactam) and aztreonam. Imipenem on the other hand was significantly less effective in mutant selection. Resistant clones broadly fell into two distinct classes. Most mutants did not show increased beta-lactamase; their resistance seemed to be due to changed outer membrane proteins. Other mutants had strongly increased cephalosporinase activity, although the derepression was only partial. Piperacillin, cefotaxime and aztreonam preferentially selected the derepressed phenotype, whereas mutants selected with cefoxitin, cefotetan, moxalactam and imipenem were exclusively of the non-derepressed phenotype. There was a significant degree of cross-resistance between the beta-lactam antibiotics except imipenem which was only slightly less active against the membrane-altered mutants.

Anti-Bacterial Agents↗
PubMed1989

[Oral manifestations in leukemic children and their diagnostic value].

Leukemia is the most common form of cancer in childhood. The disease is characterized by a high incidence of oral complications at diagnosis and during subsequent treatment. Oral complications can be divided in three groups. Primary lesions are induced by the infiltration of the oral structures by malignant cells: gingival infiltration and infiltration of bony oral structures. Secondary lesions are the result of the myelophthisic character of the disease. This group contains symptoms of anemia, increased bleeding tendency and increased susceptibility to infections. Tertiary lesions are induced by the antileukemic treatment patients receive. Direct and indirect cytotoxic effects can be distinguished. This article reviews the different oral manifestations, describes the most prominent characteristics of the different oral symptoms and demonstrates the importance of early and correct recognition of these symptoms for the oncologist. This can be important for diagnosis of the disease, but also for prevention and treatment of complications during the subsequent treatment. Dentists and stomatologists can contribute to a better prognosis and a reduction of morbidity and mortality of this disease.

Adolescent↗
PubMed1989

[Intrusion of the definitive incisors].

Intrusive luxations make up about 5% of the dental traumata on permanent front teeth. Clinical and radiological findings are described. Practical guidelines are given for the treatment of intruded teeth, with or without completed root formation, based on literature findings and clinical experience. Much attention is given to the question whether one should prefer orthodontic extrusion or choose for surgical reposition followed by immobilisation in cases of intrusive luxation of teeth with closed apices. Clinical cases are presented.

Child↗
PubMed1989

[In what way does the diet of our children affect oral-dental health? Results of a survey on the diet of school children in Louvain].

The nutritional habits of 157 schoolchildren, aged between 6 and 12 years, were recorded during a period of 7 consecutive days. The nature of food substances, the frequency of snacks between meals, the frequency of sugar intake and toothbrushing habits were evaluated. The overall response was good. Results show that three out of four children take cariogenic food substances for their breakfast. Almost half of the drinks are highly cariogenic, containing large amounts of sugar. The daily frequency of between-meal snacks lies between two and three. About 10% of the forms show a frequency of sugar intake higher than 5 per day and in more than 10% the toothbrushing frequency is zero.

Belgium↗
PubMedDate not supplied

The value of a baseline caries risk assessment model in the primary dentition for the prediction of caries incidence in the permanent dentition.

To establish a reliable screening method for caries prediction and to identify predominant risk factors, this study tested whether a cross-sectional caries risk model assessed at age 7 could be used to predict future caries onset in the permanent first molars at age 10 in 3,303 children born in 1989. As prediction variables, assessing the believed risk, baseline data at age 7 on oral health status, oral hygiene level, oral health behaviour and sociodemographic factors were used. The real risk, based on data collected for the first permanent molars during the follow-up, was assessed by different approaches. Cumulative incidence during the 3-year observation period was 31.6%, ranging from 22.4% in the believed low-risk group to 43.2% in the believed high-risk group. A stepwise logistic regression analysis was performed with net caries increment as outcome measure, adjusted for the real time at risk, using eruption times. Baseline dmfs and occlusal and buccal plaque indices were highly significant for having a high caries increment in permanent first molars with respective odds ratios of 1.07, 1.43 and 1.35. Brushing less than once a day and the daily use of sugar-containing drinks between meals were confirmed as risk factors (OR 2.43 and 1.25, respectively). The logistic regression analysis provided a sensitivity of 59-66% and a specificity of 65.7-72.8%, which indicates that the risk marker did not have an important predictive power. None of the socio-demographic and behavioural variables had enough predictive power at community level to be useful for identifying caries susceptible children. Even the power of dmfs at baseline must be considered modest.

Beverages↗
PubMedDate not supplied

Prevalence and determinants of enamel fluorosis in Flemish schoolchildren.

As part of an epidemiological study on the oral health of Flemish schoolchildren, fluoride use was studied together with risk factors (medical history, tap water fluoride concentration, use of fluoride supplements, toothpaste and brushing habits). Fluorosis was scored according to the Thylstrup-Fejerskov index (TFI) in children aged 11 years (4,128 children examined). Explanatory variables were recorded yearly, starting at the age of 7. Earliest toothpaste use was reported at the age of 1. By age 7, 99.7% of the children reported the use of toothpaste (90% fluoride-containing), but only 13.9% reported using a pea-sized amount. At age 7, 66% of the children had received systemic fluoride supplements during at least part of their childhood. At 11 years, 92% of the children used a fluoride-containing toothpaste and 6% still received systemic fluoride supplements. Fluorosis was present in about 10% of all the children examined, mainly TFI score 1 (7.3% in upper central incisors). Logistic regression established tooth brushing frequency and fluoride supplement use, in addition to tap water fluoride concentrations above 0.7 mg/l, as significant risk factors when the presence of fluorosis on at least one tooth was used as outcome variable. Children having fluorosis had a lower risk of caries, both in the primary (median dmft 1, range 0-10 vs. 2, range 0-12) and permanent dentition (median DMFT 0, range 0-5 vs. 0, range 0-11).

Analysis of Variance↗
PubMedDate not supplied

Effect of caries experience in primary molars on cavity formation in the adjacent permanent first molar.

This study sought to address the influence of a sound versus affected first and/or second deciduous molar on the incidence of visible caries experience in the adjacent permanent first molar. Clinical and questionnaire data were obtained from a 6-year prospective oral health screening project in Flanders, Belgium (Signal-Tandmobiel project), where 4,468 children (born in 1989) were examined annually during their primary school time. A multiple survival model allowing for dependent data with possible censoring was applied. The impact of timing of tooth emergence (determining the period at risk), gender, presence of sealants and reported oral hygiene habits was also considered. Cavity formation in permanent first molars was clearly influenced by the status of the adjacent primary molars;the effect of the second deciduous molar was most pronounced. Moreover, if both deciduous molars experienced caries and the child presented with poor oral hygiene, a peak in cavity formation of the permanent first molar 1-2 years after emergence was noticed. On the other hand, if a child presented with good oral hygiene, no peak was observed; caries risk increased slightly over time. No significant benefit from restoring primary molars could be demonstrated, possibly because of methodological limitations.

Child↗