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Biomedical subjects

D De Anna

Publications and source records attributed to D De Anna.

At least 55 records · Page 3Linked to original sources

[Prospective surgery in the treatment of acute pancreatitis].

A series of 65 patients with acute pancreatitis is analyzed with special regard to ethiopatogenesis and therapy. In several cases (68%) surgery has been performed with good results. Results are discussed and confronted with bibliographic report. The main problem, according to Authors, is to diagnose the real cause of pancreatitis for every patient, so that is possible to choose the appropriate may of treatment.

Acute Disease↗

[Anti-edema activity of injectable Venoruton in abdominal surgery].

The anti-oedema activity of an injectable drug (HR; active principle: 0-(beta-hydroxyethyl)-rutoside) was assessed in 60 gastric extrahepatic bile duct, and large intestine surgery patients (30 being used as controls). Gastroscopy (with biopsy), gastroduodenoscopy, colonoscopy (with biopsy) and radiological examination were usually performed on the 5th and 10th post-operative days. The drug showed significant therapeutic effects: rapid resolution of oedema, especially at the sutures, leading to early cicatrisation, canalisation and the prevention of dehiscence. Finally, duration of hospitalisation was less than in the untreated cases. The gastroscopic, radiographic and biopsy findings are considered to have shown clear evidence of the drug's action against oedema formation.

Adult↗

[The role of supraduodenal choledocho-duodenostomy in non-neoplastic obstructive pathology of the principal bile duct].

The authors review the indications of their 146 cases of supraduodenal choledochoduodenostomy (SDC) from 1970 to 1977. The conditions for which the procedure was carried out were dilatation of the choledochus (100%), multiple calculosis (83%), and primitive or secondary stenosing odditis (17%). After a detailed discussion of these indications, the authors report their immediate and long-term results, which were good in 96% of the patients. In the matter of surgical technic the authors give preference to laterolateral SDC, stressing that effective anastomosis requires a choledochal diameter of at least 10 or 12 mm. In good accord with data published from other sources, the authors' data suggest further restriction of direct procedures (in view of the associated risk of acute pancreatitis) in favor of SDC. The authors also review the objections to, and complications of, this surgical procedure, and conclude that these are never so important as to discourage the procedure when definitely indicated.

Cholangitis↗

[So-called cystic stump syndrome].

After outlining and discussing the etiology and pathophysiology of the postcholecystectomy syndrome, the authors describe their own series of 35 cases, therapeutic policies, and results obtained. In the discussion they suggest that the so-called cystic stump syndrome has probably been overplayed, since in the authors' own series of cases there was a high incidence of associated pathology.

Bile Duct Diseases↗

[Agenesis of the gallbladder. Presentation of a case].

The authors describe one case of agenesis of the gallbladder associated with papillary stenosis, dyskinesia of the extrahepatic bile ducts, and chronic appendicitis. They devote particular attention to the composition of hepatic bile and choledochal bile, which was investigated in detail after surgical exploration of the extrahepatic bile passages, transduodenal papillosphincterotomy, and appendectomy. They conclude that this rare congenital failure of organ development, in the long run, even a slight alteration of bile composition in the hepatic and/or choledochal segment of the biliary tract (the latter somewhat serving the purpose of the missing gallbladder) may invite calculosis of the common bile duct.

Adult↗

[Post-amputation dehiscence. A problem resolved].

70 peripheral amputations of the lower extremities in arteriosclerotic and diabetic vasculopathics have been examined. In a number of cases, the postoperative period was complicated by dehiscence of the suture on the stump, with lengthening of hospitalization time, risk of infection in the underlying bone and thus further amputation. To solve this problem, dehiscence was treated with dermo-epidermal autografts to cover the missing tissue area. The dehiscence was cleaned with compresses of 2% amuchina associated with topical instillations of Lincomycin hydrochloride. The cure percentage after grafting was about 80%.

Aged↗

[Chemotherapeutic prophylaxis in the preparation of the large intestine for surgical interventions: rifaximin P.O. vs. cephalosporin I.V].

30 patients were examined: 17 males and 13 females aged between 53 and 83 years (average age 66 years), candidates for large intestine surgery. For 5 days before the operation, they were treated at random, in a balanced way, with cefotaxime (3 g/day intravenously), either alone or associated with rifaximin (1200 mg/day P.O.). Rifaximin, an antibiotic drug endowed with a topical intestinal action, substantially increased the antibacterial activity of the well known and traditional third-generation cephalosporins therapy in the prevention of bacterial infections after major colic surgery. Intestinal bacterial load and pathogenic micro-organisms reduction was substantially increased. Furthermore, a more limited onset of post- surgical complications was observed, together with a better post-surgical clinical course, and a more rapid recovery of normal intestinal functions. The possibility of carrying out an effective chemoprophylaxis by means of an oral drug, such as rifaximin, must be encouraged as, among other things, it substantially reduces the intolerance risk at systemic level, which is nevertheless possible with parenteral antibiotic treatments.

Administration, Oral↗

[Tumors of the carotid glomus (chemodectomas)].

Two cases of carotid body tumor (chemodectomas) have been reported and at this regard the international literature reviewed. Concerning the diagnosis selective angiograms represent the investigation of choice in clinical assessment and planning operative approach. Doppler-ultrasound results particularly useful in the follow up of patients after surgery. With advances in vascular technique, complete excision of the tumor has become possible and is now associated with minimal morbidity and mortality. Survival rate of resected patients is equivalent to that for sex age matched control subjects.

Carotid Body Tumor↗