A radiopharmsceutical product, labelled macroaggregates of albumin (M.A.A.), which is in use as a lung scintiscanning agent has been noted to have an affinity for venous thrombi. With this material and an inexpensive portable scintillation detector we have attempted to diagnose and localize thrombi in leg veins. The procedure is performed at the bedside and the result is available in 30 minutes. Thirty-one patients with clinical evidence suggestive of deep venous thrombosis in the legs were studied by the radioisotope method and by phlebography. There was agreement in 18 of 21 legs shown to contain thrombus on phlebography and in 9 of 10 legs shown to be free of thrombosis on phlebography. There was, however, lesser agreement on the site of thrombosis between the two methods. The ease of performing the test combined with the rapidity of obtaining results and accuracy in diagnosis suggests that the test has a clinical application.

Adolescent↗

PubMed1972

Pylorus-preserving gastrectomy in the treatment of duodenal ulcer.

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Adult↗

PubMedDate not supplied

[Blood tumor markers in patients with lung cancer].

Over the past years, a number of serum components have been confirmed as useful biological markers of lung cancer. Although none have been sensitive or specific enough to enable early diagnosis, they do seem to facilitate the monitoring and prediction of disease prognosis. We studied tumor markers in 66 patients with lung cancer: serum levels of ferritin, carcinoembryonic antigen (CEA), alpha-fetoprotein (alpha-FP); tissue polypeptide antigen (TPA), cytocheratin fragment 19, 21-1 (CYFRA 21-1) and carbohydrate antigen 125 (CA 125) levels were measured and correlated to tumor stage and histological type. Postulating a specificity of 95% versus benign diseases of the lung, we confirmed the following diagnostic sensitivity for the markers: ferritin = 39.3%; CEA = 42.4%; alpha-FP = 5.1%; TPA = 57.5%; CYFRA 21-1 = 65.1%; CA 125 = 46.9%. CYFRA 21-1 showed significantly higher sensitivity in non small cell lung cancer patients than in those with small cell lung cancer (Wilcoxon, p = 0.02). Moreover since survival time was significantly shorter in patients with high serum CYFRA 21-1, these levels seemed to be correlated with the prognosis.

Aged↗