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Biomedical subjects

D D Pekovic

Publications and source records attributed to D D Pekovic.

9 recordsLinked to original sources
PubMed1991

Invasion of bacteria in enamel carious lesions.

A review of recent findings concerning enamel carious lesions is presented. This lesion represents the initial phase of dental caries and is characterized by a demineralization of the subsurface enamel caused by acids of the plaque bacteria. Streptococcus mutans has been described as the etiologic agent of the dental caries and the most acidogenic plaque bacteria. Morphological studies have shown an invasion of microorganisms inside the enamel carious lesion. Unfortunately, several technical problems are associated with such studies. The identification of the invading bacteria has not yet been achieved. The future identification of bacteria inside the subsurface enamel lesions will represent an important step in the prevention of the carious progression.

Dental Caries↗
PubMed1988

Immunoglobulins in human dental caries.

The penetration and complement fixation of sIgA, IgM and IgG were studied in advanced human dental caries with double-staining immunofluorescence technique. Immunoglobulins were found in dental plaque and in the superficial layers of the lesions which were exposed to saliva. sIgA was the most frequent, followed by IgG and IgM. IgG had the greatest capacity for penetration into the lesions, followed by IgM and sIgA. IgM was most frequently found in association with complement C3.

Complement C3↗
PubMed1987

Pathogenicity of HIV in lymphatic organs of patients with AIDS.

HIV antigens were searched for in the thymus, lymph nodes, bone marrow, and spleen of AIDS patients, by means of immunofluorescence technique. Human IgG against HIV and monoclonal antibodies against viral gag P24 protein yielded strong cytoplasmic fluorescence of cells in sections of the thymus, lymph nodes and spleen. Some cells containing HIV antigens were morphologically multinucleated giant cells. They reacted with monoclonal antibodies against helper/inducer T-cells (OKT4+), and were complexed with antibody or with complement as demonstrated by double-staining immunofluorescence technique. A large number of inflammatory cells infiltrated the thymus in areas containing cells expressing HIV antigens. These studies demonstrated an association of HIV virus with cytopathic and immunopathogenic reactions in lymphatic organs of AIDS patients, and are consistent with previous results, as well as indicative of a primary aetiologic role for the virus.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Identification of bacteria in association with immune components in human carious dentin.

Actinomyces viscosus, A. naselundii, Streptococcus mutans serotype "c" and S. mutans serotype "d/g" were identified in human carious dentin using histological and immunofluorescent techniques. A. viscosus was most frequently found in association with patient's immunoglobulins and complement, followed by S. mutans serotype "d/g", S. mutans serotype "c", and A. naeslundii.

Actinomyces↗
PubMed1986

Detection of HTLV-III/LAV antigens in peripheral blood lymphocytes from patients with AIDS.

HTLV-III was searched for in frozen sections of peripheral blood lymphocytes obtained from AIDS patients by an immunofluorescence technique. Human IgG against HTLV-III/LAV and monoclonal antibodies against HTLV-III/LAV P 24 antigen, yielded a strong cytoplasmic fluorescence in frozen sections of the lymphocytes. Some cells containing HTLV-III antigens displayed multinucleated giant forms. They also reacted with monoclonal antibodies against helper/inducer T-cells (OKT4+), as demonstrated by direct double staining immunofluorescence. Similarly, complexes of immunoglobulins and C3 component of complement were also detected on HTLV-III/LAV Ag expressing lymphocytes. Immunofluorescence study of frozen sections of peripheral blood lymphocytes appeared to be a simple, fast and reliable method for detection of HTLV-III/LAV Ag in AIDS patients.

Acquired Immunodeficiency Syndrome↗
PubMed1980

Rodent incisor pulp, isolation and sectioning.

Experimental technics are described for a quick isolation of the dental incisor pulp in rodents, and for the wrapping of the pulp in a sheet of guinea pig muscle as a prerequisit for cryostat sectioning.

Animals↗
PubMed1978

[Allergies and dental pulp (author's transl)].

A review of the articles dealing with allergy in the dental pulp is oppered. The dental pulp--furthermore when inflamed--showes antigens, lymphocyetes and plasmocytes, antibodies (IgG, IgA and IgE), mast-cells, histamine and possibly C3. However an hypersensitivity or allergy of immediate type elicited by circulating antibodies has never been demonstrated. In another way, two types of allergies of cellular type have been described in the dental pulp: graft rejection and contact hypersensitivity. Autoimmunity has also just been described.

Animals↗