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Biomedical subjects

D D Orlovskaia

Publications and source records attributed to D D Orlovskaia.

7 recordsLinked to original sources
PubMed1992

[Neuromorphology and neurochemistry of senile dementias in the light of studies on glial response].

The present study describes a few morphological and neurochemical disturbances in astroglial cells in senile dementia of the Alzheimer type (SDAT). The greatly elevated number of fibrous astrocytes in brain samples with SDAT is observed. The content of glial fibrillar acid protein is elevated in these cells. Glial filaments are detected to surround lipid centers. Moreover, there are deviations in energy metabolism: a profound decrease in the levels of the brain creatine kinase CKBB that is one of the principle ATP-regulation enzyme. It is suggested that there is a relationship between all the disturbances observed in glial cells of SDAT patients. These disturbances are likely to be links of the same process which leads to abnormal brain ageing.

Alzheimer Disease↗
PubMed1979

[Microglia-type cells in normal and pathologic human embryonic brains].

The brains of 7--12 week embryos, developing in normal and mentally ill females (normal--14, schizophrenia--12, other mental disorders--10) were studied by means of electron microscopy. It was established that the cells of the microglia type may be encountered in the brain of embryos beginning from 7 weeks. In the brain of embryos from normal females these cells had mainly a round or oval form (globose microglia). Axons were encountered relatively rarely. Some of the cells had protrusions of the pseudopodia-like type. In the brain of embryos from mentally ill females the cells of the microglia type have diverse, sometimes sticklike forms; they form multiple thin axons, actively fagocyte. The ultrastructure in such conditions was not destructed. These changes are considered to be the result of an increased activity of microglial cells under the influence of factors of the pathological process.

Brain↗
PubMed1976

[Changes in the ultra-fine structure of capillaries of the embryonic brain in the presence of schizophrenia in the mother].

The report is concerned with a study of fine structures of brain capillaries in 9 embryos received during medical abortions from schizophrenic mothers. The authors established some traits in the ultrastructure of endothelial cells in most of the studied cases--an increase of the surface of endothelial cells at the expense of a tortuosity of their plasmatic membranes and a formation of growths, vacuolization of the cytoplasma. There were also some changes in the structure of basal membranes. In 2 cases there were also peculiar pathological changes in the vascular endothelium: granules of an unknown nature in the endothelial cells and a focal lysis of the plasmatic membranes of endothelial cells.

Brain↗
PubMed1975

[Ultrastructural features of brain cells from the embryos of schizophrenic women].

With the use of the electron microscope the authors studied the embryonic brain tissue obtained during medical abortion of 6 female schizophrenic patients. Ultrastructural peculiarities of the cell elements in the embryonic brain in theses cases were estimated in comparison with those found in the embryonic brain of 14 mentally healthy women. There is a description of damages of membranes, mitochondrias and accumulation of granular material in the cytoplasma.

Brain↗