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Biomedical subjects

D D Nghiem

Publications and source records attributed to D D Nghiem.

At least 19 recordsLinked to original sources
PubMed1992

Pancreatic flush injury in combined pancreas-liver recovery.

The function of pancreatic grafts harvested from six pancreas-liver (PL) donors was compared to that of nine pancreas-alone (PA) donors. All donors had comparable physiological parameters. Pancreas and liver were flushed in situ with 4C Collins solution and the portal vein was vented immediately. The pancreaticoduodenal grafts were reflushed and stored in Collins solution (three PA and two PL), silica gel-filtered plasma (six PA and two PL), or University of Wisconsin solution (two PL). Later they were revascularized by the iliac vessels and drained into the bladder. All pancreas recipients were insulin-dependent. Serum glucose, amylase, lipase, blood urea nitrogen (BUN), creatinine, protein, albumin, and urine amylase, bicarbonate and pH were monitored for 12 days. Data were analyzed using the Mann-Whitney U-test and Fischer's exact test. The PL grafts received a significantly higher aortic flush volume (5983 cc vs 1622 cc, P = 0.001) than those in the other group. Recipients of PL grafts had higher serum amylase (335 vs 250 IU/l) and lipase (1048 vs 424 IU/l), significantly lower levels of urine bicarbonate (11.2 vs 27.1 mEq/l, P = 0.01), pH (6.8 vs 7.3, P = 0.04), and amylase (9202 vs 19,981 IU/l, P = 0.05) than those in the PA group.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1992

Eversion endarterectomy of the cadaver donor renal artery: a method to increase the use of elderly donor kidney allografts.

Eversion endarterectomy was used to treat severe arteriosclerosis of the renal artery in 34 cadaver kidneys from elderly donors that have been considered unsuitable by other transplant centers. All kidneys were transplanted after biopsy confirmed normal histology. Graft survival and mean serum creatinine level at 4 years were 76.4% and 2.3 mg./dl., respectively. Use of these kidneys increased the number of cadaver kidney transplants at our center by 18%.

Adult↗
PubMed1991

En bloc transplantation of kidneys from donors weighing less than 15 kg. into adult recipients.

En bloc transplantation of kidneys from donors who weighed less than 15 kg. into 20 adult patients is described. Intraperitonealization of the medial kidney allowed adequate renal positioning and growth. Graft venous thrombosis occurred in 1 patient and irreversible graft rejection occurred in 4 patients. Graft survival was 65% with excellent function at a mean followup of 8.8 months. En bloc transplantation of pediatric cadaver kidney grafts in adults is an acceptable procedure.

Adult↗
PubMed1990

Physiologic studies of urinary drained pancreaticoduodenal grafts in humans.

Exocrine function of urinary drained pancreas transplants (UDP) as determined by measurements of urinary pancreatic metabolites was assessed in 15 recipients. Normal UDP showed significantly higher levels (P less than 0.05) of urinary amylase, (42,931 +/- 5135 U/liter), HCO3 (27.12 +/- 3.18 meq/liter), and pH 7.83 +/- 0.15) than nine other recipients of enteric drained pancreas transplants with corresponding values of 168.00 +/- 2.00 U/liter, 3.20 +/- 0.20 meq/liter, and 6.08 +/- 0.27. These urinary metabolites dropped significantly (P less than 0.02) during rejection to 13,576 +/- 3446 U/liter, 19.22 +/- 5.74 meq/liter, and 7.06 +/- 0.14, respectively. These changes preceded elevation of blood sugar levels by 2-3 days. During rejection episodes, pancreatic grafts failed also to excrete bicarbonate and amylase significantly in response to secretion stimulation (P less than 0.05) contrary to nonrejecting pancreata. It is concluded that decreases in urinary amylase, HCO3, and pH observed with and without secretin stimulation are simple markers of pancreatic rejection.

Amylases↗
PubMed1989

The role of calcium antagonists in the management of renal warm ischemia.

Eighty dogs with solitary kidneys were used to investigate the effects of calcium antagonists on the functional capacity and structural integrity of kidneys subjected to sixty minutes of warm ischemia by transient vascular occlusion under general anesthesia. Treated dogs were compared with control animals who had normal or untreated ischemic kidneys (group 1 and 2) and also with saline-flushed ischemic kidneys without or with heparinization (group 3 and 4). Verapamil and nicardipine were used independently as local (group 5 and 7) or systemic treatment (group 6 and 8). Functional and structural studies revealed that calcium antagonists improved animal survival, renal hemodynamics, renal functional capacity, cellular adenine nucleotides, and reduced the ischemic structural damage. Local treatment of ischemic kidneys with 0.15 mg. nicardipine afforded the best protection against the deleterious effects of renal warm ischemia.

Animals↗
PubMed1989

Pancreatic transplants: evaluation with MR imaging.

Eighty-eight magnetic resonance (MR) imaging studies of 31 pancreas transplants in 30 patients were performed. The postoperative graft usually appears enlarged and inhomogeneous, with patchy areas of increased signal intensity on T2-weighted images that may last 3-4 weeks. During acute rejection, T1-weighted images of graft abnormalities show a decrease in signal intensity, similar to that of muscle, and T2-weighted images show an increase in signal intensity, equal to or higher than that of the bladder. The pattern of abnormal signal is most frequently multifocal but can be diffuse, and the graft may be enlarged. During recovery from rejection, the graft parenchyma shows a decrease in signal intensity (less than that of the bladder) on T2-weighted images when compared with that of acute rejection. During chronic rejection the graft is small and shows low signal intensity, slightly higher than or similar to that of muscle, on both T1- and T2-weighted images. MR imaging appears to be useful for detection of early pancreas allograft rejection and complications in conjunction with clinical findings, laboratory data, and other radiologic procedures.

Acute Disease↗
PubMed1988

Nosocomial aseptic meningitis associated with administration of OKT3.

An outbreak of nosocomial aseptic meningitis involving four renal allograft recipients on the transplant service occurred in July 1986, shortly after the release of the murine monoclonal antibody OKT3 for therapy for acute allograft rejection. No bacteria, fungi, or viruses were isolated from cultures of the cerebrospinal fluid of the four patients. All four had acute allograft rejection treated with OKT3 and developed signs and/or symptoms of meningitis within 72 hours of receiving the drug. To identify potential risk factors, the four patients with aseptic meningitis were compared with 12 patients on the renal transplant service in July 1986 who did not have signs or symptoms of meningitis. The development of aseptic meningitis was strongly associated with administration of OKT3. Because of this association, prospective surveillance of meningitis in patients receiving OKT3 was instituted. From November 1986 to May 1987, three (14%) of 21 patients treated with OKT3 developed aseptic meningitis. The clinical course of aseptic meningitis associated with OKT3 appears to be benign and self-limited. Nonetheless, this observation warrants continued surveillance of OKT3 therapy.

Antibodies, Monoclonal↗