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Biomedical subjects

D D Glass

Publications and source records attributed to D D Glass.

9 recordsLinked to original sources
PubMed1992

Con: whole blood transfusions are not useful in patients undergoing cardiac surgery.

Data supporting fresh whole blood transfusion or fresh component therapy are nonblinded, and although both are conceptually attractive, neither can be considered proven. Recent blinded studies reflect fresh blood ineffectiveness. Larger, blinded, randomized trials will need to be performed. Proven methods of blood conservation as well as standardized criteria for transfusion of blood components will more effectively decrease homologous blood transfusion. Transfusion of fresh or banked whole blood, or its components, has yet to be shown to decrease the usage of homologous blood products.

Blood↗
PubMed1991

H chain C domains influence the strength of binding of IgG for streptococcal group A carbohydrate.

We have produced a panel of murine anti-streptococcal mAbs, expressing identical V domains and different H chain C domains, corresponding to the IgG3, IgG1, and IgG2b subclasses. We have used these mAb to evaluate the role of IgG subclass-specific C region determinants in modulating the interaction between antibody and the bacterial surface. We report, for the first time, that V region-identical murine IgG of different subclasses exhibit substantial differences in binding to specific Ag; IgG3 mAb binds more strongly to streptococci than the IgG1 and IgG2b mAb or IgG3-derived F(ab')2 fragments. Furthermore, the IgG3 mAB binds cooperatively to the bacteria, whereas the IgG1, IgG2b, and IgG3-derived F(ab')2 fragments do not exhibit significant cooperativity, which suggests that differences in Fc region structure can affect antibody binding to multivalent Ag by modulating the potential for cooperative binding. These results suggest a plausible mechanism by which murine IgG3 could be more effective, than other antibodies bearing identical V domains, but of different gamma-subclass, in mediating bacterial immunity.

Animals↗
PubMed1977

Pulsus alternans: its therapeutic implications.

Pulsus alternans is a pulse pattern in which the beats occur at constant intervals but with the regular alternation of the peak of the pressure pulse. Pulsus alternans frequently indicates heart failure due to disease of the left ventricle and will be seen with increasing frequency as more patients are invasively monitored. This report describes four patients who had pulsus alternans and the interventions that resulted in its disappearance. These cases would seem to support previous findings in experimental animals that the appearance of pulsus alternans may be related to myocardial ischemia. A review of the current concepts on the pathophysiology of pulsus alternans is included.

Adolescent↗
PubMed1977

Intermittent mandatory ventilation.

The introduction of the concept of intermittent mandatory ventilation (IMV) has meant that for the first time weaning is controlled. The abrupt cessation of ventilatory support, even for short periods, as was obligatory before IMV, is no longer necessary. The frequency of positive pressure inflations can be gradually and progressively decreased as indicated, leading to spontaneous ventilation in a planned, controlled program. The ease with which other artificial ventilation technics may be incorporated into this system adds to its usefulness. IMV should be considered whenever ventilatory support is to be discontinued.

Adult↗
PubMedDate not supplied

Therapy of unilateral pulmonary insufficiency with a double lumen endotracheal tube.

Successful therapy of unilateral acute lung disease has been infrequent. The marked compliance difference that exists between the acutely diseased and normal lung may make conventional respiratory therapy ineffective in treating the diseased lung. Vigorous attempts at reexpansion of the involved lung including bronchoscopy, continuous positive pressure ventilation, chest physiotherapy, suctioning, and position changes are usually successful in acute lung disease but were ineffective in the case presented. The use of the double lumen endotracheal tube, Carlens tube, and the application of differential ventilation was a safe and effective modality of therapy when conventional measures failed. The method of ventilation and the patient's course are described.

Aged↗