Nature as medicine: the healing power of the wilderness.
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Humans↗
Biomedical subjects
D Cumes
Publications and source records attributed to D Cumes.
125Iodine prostate implants for recurrent carcinomas after external beam irradiation: preliminary results.
Fourteen patients with locally recurrent prostate carcinomas after external beam irradiation received 135I seed implants at Stanford between 1975 and 1979. Clinical local control has been obtained in 11 of the 14 patients for follow-up periods of 6 to 36 months. Eight remain without evidence of disease, but 2 of the 3 patients whose pelvic lymph nodes were involved by carcinoma have developed distant metastases. Complications, consisting of either cystoproctitis, urinary incontinence, or the development of a vesicorectal fistula occurred in 4 of the 14 patients. These complications were noted only in those patients who had implantation of high intensity 125I seeds (greater than 0.50 mCi) into large prostatic volumes (greater than or equal to 50 cc). No complications occurred in patients who received lower intensity 125I seed implants in smaller prostatic volumes. We conclude that 125I seed implants may be used in a second attempt to obtain local control after a local relapse following external beam irradiation, if the use of high intensity 125I sources and/or the implantation of large prostate volumes are avoided.
Acid Phosphatase↗
Intraperitoneal rupture of pseudodiverticulum of bladder.
A case is presented of a pseudodiverticulum of the bladder which developed after a bladder rupture nine years previously. In this case, rupture of the pseudodiverticulum occurred intraperitoneally. The pseudodiverticulum communicated with the bladder via a small fish-mouthed opening surrounded by attenuated fibrotic bladder wall.
Adult↗
The effect of sympathectomy on the urethral pressure profile in the experimental animal.
The effect of sympathectomy and various pharmacologic agents on the dog urethral pressure profile (UPP) was assessed. Succinylcholine was used to subtract the effect of the external urethral sphincter from the total UPP. In the presence of succinylcholine effect, sympathectomy caused a decrease in the UPP in 12 of 13 experiments. In addition, an attempt was made to elicit a denervation sensitivity response to phenylephrine after sympathectomy; none could be shown. Measurements were made of UPP's after administration of both succinylcholine and phenylephrine. Seven of the 13 dogs showed a significant decrease in UPP after succinylcholine administration. Nine of 12 dogs showed a marked increase in UPP after phenylephrine was given.
Animals↗
Sacral dysgenesis associated with occult spinal dysraphism causing neurogenic bladder dysfunction.
A case of a neurogenic bladder in a 20-year-old man is described. The patient had difficulty in voiding and incontinence, with a history of several urinary infections. Misdiagnoses included stricture and posterior urethral valves. Early treatment included urethral dilation, a transurethral resection and a left ureteral implantation. Throughout this time the neurological examinations were essentially normal. Final diagnosis was sacral dysgenesis with associated occult spinal dysraphism, after the discovery of a small pock mark over the sacrum and an abnormal pelvic x-ray. Urinary diversion was done.
Adult↗