Search PubMed⌕ Search

Biomedical subjects

D Crippen

Publications and source records attributed to D Crippen.

At least 37 records · Page 2Linked to original sources
PubMed1997

Quality improvement?

Explore the source record for details and available documents.

Education, Continuing↗
PubMed1995

Understanding the neurohumoral causes of anxiety in the ICU. Clinical consequences include agitation, brain failure, delirium.

Severe anxiety can disrupt neurohumoral metabolism and lead to agitation and brain failure, which may result in delirium. Predisposing factors include cerebral vascular or endocrine insufficiency, cardiopulmonary decompensation, poor tissue perfusion, multiple medications, and sleep-wake cycle disruption; the stressful ICU environment puts patients especially at risk. Stress-induced noradrenergic hyperactivity can precipitate panic attacks; dopaminergic hyperactivity can lead to delirium (marked by paranoid delusions, visual or auditory hallucinations, and psychomotor agitation). The underlying cause of anxiety must be identified to guide appropriate therapy.

Anxiety↗
PubMed1994

Brain failure in critical care medicine.

The intensive care unit is an area where high-technology life support systems are capable of turning around multiple organ system failure. By its nature, this care plan confers a great deal of stress on the patient and sets the stage for the phenomenon of brain failure, a syndrome where neurotransmission is disrupted by the combined forces of environmental stress and underlying disease. When agitation follows brain failure, the resulting condition may result in formidable somatic aftermath. Accurate recognition of brain failure and its co-morbidities can facilitate effective treatment and avoid long-term hemodynamic and metabolic consequences. Computer-interpreted cerebral function monitors can noninvasively assay cerebral function at the neuronal level under heavy sedation regimens when the visual clues of brain function disappear.

Coma↗
PubMed1992

Rationing and regionalisation of health care services: a critical care physician's opinion.

It is becoming apparent that we have created a demand for medical goods and services that threatens to overwhelm our health care system. Present fiscal policies for financing health care such as excluding a large portion of the population are clearly unacceptable to the public. Current reimbursement policies for health care providers are so murky and, in some cases, so conflicting that they could have been designed only as a method of rationing by inconvenience. Some improvements in the cost effectiveness of health care delivery are needed without increasing the administrative and regulatory bureaucracy currently feeding on itself. Regionalisation of medical services has proven to be cost-effective in the specialties of trauma and neonatology. There is accumulating evidence that this same concept, using severity of illness scoring as an objective marker of potential benefit, may maximise cost/benefit for medical and surgical critical care patients. However, multifaceted deterrents to the concept of regionalisation must be addressed, including reimbursement problems, logistics of bed occupancy and physician incentives to participate.

Canada↗
PubMed1991

Dying pattern in volume-controlled hemorrhagic shock in awake rats.

We previously determined that in awake, unmonitored Sprague-Dawley rats, bleeding of 2.5 ml/100 g over 20 min resulted in hemorrhagic shock (HS) with about a 75% survival rate over 24 h, and bleeding of 3.0 ml/100 g in about 25% survival to 24 h. In the present study, we monitored systolic and mean arterial pressure (MAP), central venous pressure (CVP), breathing movements, electroencephalogram (EEG), and arterial blood gases to 3 h in order to study dying patterns. After cannulation under light anesthesia and awakening for 2 h, the rats were bled over 20 min. Ten rats in each of four groups were studied. Shed blood volume (SBV) in group I was 2.0 ml/100 g; in group II, 2.5 ml; in group III, 3.0 ml; and in group IV, 3.5 ml. Three hour survival rates were 100% for group I, 80% for group II (survival time 149 +/- 65 [106-180] min), 40% for group III (survival time 116 +/- 72 [93-180] min), and 0% for group IV (survival time 32 +/- 38 [5-69] min). MAP decreased at end of bleeding, increased transiently to moderately hypotensive levels (attempted self-resuscitation), and then either recovered to normotension or declined to cardiac arrest (death), which was defined as simultaneous apnea, systolic arterial pressure less than or equal to 30 mmHg without pulsations, and isoelectric EEG. EEG depression began with hypotension to MAP less than or equal to 50 mmHg. During HS, PaO2 increased, and PaCO2, pHa, and Hct all decreased. The results suggest that this model with SBV of 3.25 ml/100 g would give a low, but not zero 3 h survival, and therefore would be suitable for the study of responses to field resuscitation potentials.

Animals↗
PubMed1991

Improved survival of hemorrhagic shock with oxygen and hypothermia in rats.

A previously established model in awake rats of hemorrhagic shock (HS) with 25% spontaneous survival rate (without resuscitation) was used to evaluate the effects of 4 novel life-supporting first aid (LSFA) measures on survival time and rate. After shed blood volume (SBV) of 3.25 ml/100 g, withdrawn over 20 min, hemodynamic and respiratory responses were recorded to 3 h and survival to 24 h. The 5 groups of 20 rats each (total n = 100) were as follows: group I, controls without treatment; II, oxygen 100% inhalation; III, external cooling to rectal temperature 30 degrees C; IV, Ringer's solution 5 ml/100 g rectally; and V, acoustic and surface stimuli for arousal. Survival rates were: control group I, 35% at 3 h and 15% at 24 h; oxygen group II, 75% (P less than 0.05 compared with group I) at 3 h and 60% (P less than 0.05 compared with group I) at 24 h; hypothermia group III, 65% at 3 h and 45% (P less than 0.05 compared with group I) at 24 h; rectal fluid group IV, 50% at 3 h and 40% at 24 h; stimulated group V, 15% at 3 h and 15% at 24 h. Compared with group I, median survival times during HS 0-3 h were longer in groups II and III; and self-resuscitation attempts were longer in groups II, III and IV. We conclude that in untreated severe hemorrhagic shock, chances of survival to delayed arrival of advanced life support with i.v. fluid resuscitation might be increased with O2 inhalation and/or moderate external cooling.

Animals↗
PubMed1990

Critical care transportation medicine: new concepts in pretransport stabilization of the critically ill patient.

Regionalization of health care for trauma has become commonplace, and the same concept for critically ill medical/surgical patients is developing. Recent evidence suggests that current stabilization measures used by transport teams can be inadequate for this critically ill patient population. In trauma, speed has been considered a necessity to get the patient to a facility which cannot be carried out to the field, eg, an operating room. For acute medical illnesses, critical care transport teams can bring intensive care technology to the patient. Accumulating evidence supports the premise that speed of transport is not as important as stabilization before transport, knowledge of hemodynamics during transport, and early use of critical care monitoring systems. Other reports identify the need for initial evaluation and stabilization of critically ill patients by physicians at the critical care level of expertise. Accordingly, critical care transportation teams have evolved, creating new notions of pretransport stabilization not applicable to previous transport systems.

Emergency Medical Services↗
PubMed1985

Acute medical care for championship auto racing.

Auto racing is a diverse sport in terms of car design and sophistication, topography of race courses, speeds achieved, and driver experience. These factors relate directly to potential hazards of auto races and the approaches to safety utilized by the groups conducting these events. The evolution in recent years of technologically advanced racing machines capable of speeds exceeding 200 mph has mandated commensurate sophistication in acute medical care programs serving professional racing teams. A comprehensive team approach to the on-track evaluation and treatment of speed-sport-related trauma is described.

Accidents↗