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Biomedical subjects

D Crase

Publications and source records attributed to D Crase.

28 records · Page 2Linked to original sources
PubMedDate not supplied

Death education coverage in selected health education books and periodicals.

This article represents an attempt to ascertain the quantity of death and dying literature within selected health education periodicals and introductory health education books during the past 7 years. The study is part of an ongoing effort by the author to determine relationships between health education and death education. Approximately two-thirds of the general health education books reviewed now include chapters or sections on death-related phenomena. Four nationally refereed periodicals, viewed by the author as most useful to the health educator, have also been publishing a considerable number of death education pieces in recent years. Involvement by health educators, via the publication of death and dying information, should be viewed as a positive gesture toward achieving multidisciplinary goals within death education.

Attitude to Death↗
PubMedDate not supplied

Minimizing resistance to death education.

Death education is now an accepted phenomenon within institutions of higher education. Death education is also being taught at the elementary and secondary school levels though less is known about its acceptance as a worthwhile pedagogical endeavor by parents of school-age children. This article addresses the potential sensitivity and hesitation parents may demonstrate relative to death education's delicate, multifaceted subject matter and offers some suggestions for minimizing possible resistance to death and dying pedagogy. Any resistance that parents demonstrate is generally due to their own fear of death and dying and their inability to deal realistically with it. Certain antecedents of fear and strategies for coping with fear are offered.

Attitude to Death↗
PubMedDate not supplied

Pharmacokinetics and tissue distribution of recombinant human tumor necrosis factor-alpha in mice.

The serum pharmacokinetics and the major organs of accumulation of recombinant human tumor necrosis factor-alpha (rHuTNF) were determined in BDF1 mice after intravenous and intramuscular administration. Serum concentrations of immunoreactive protein were determined by enzyme-linked immunosorbent assay, and radioactivity was quantitated by beta and gamma scintigraphy. The serum pharmacokinetics of labeled and unlabeled rHuTNF were identical when administered by the intravenous route. After intravenous doses of 165 to 320 micrograms/kg, the clearance was 2.9-3.6 ml/hr, the initial volume of distribution was 1.4-1.6 ml (70-80 ml/kg), and the half-life was 18.5-19.2 min. Intramuscular administration of 320 micrograms/kg resulted in a peak serum concentration of 112 ng/ml. The time of the peak concentration was 1 hr, and the bioavailability of the intramuscular dose was 12%. The data suggest that the disposition of this protein may be biexponential. If this is the case, the terminal phase would appear to account for less than 1% of the total AUC. Since serum concentrations in the terminal phase are at the sensitivity limit of the assay, a single half-life is reported. 125I-Labeled and metabolically labeled 3H-rHuTNF were used to examine tissue distribution. After intravenous 125I-rHuTNF administration, the rank order of accumulation of the 125I-radiolabel in the major organs (per cent dose per organ over 1440 min) was: liver greater than kidney greater than lung greater than heart greater than spleen. This rank order of accumulation was confirmed by intravenous 3H-rHuTNF administration.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗