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Biomedical subjects

D Courtois

Publications and source records attributed to D Courtois.

At least 37 records · Page 2Linked to original sources
PubMed1979

Inducibility of microsomal enzymes in normal and pre-cancerous lung tissue. Synergistic action of 5-6 benzoflavon or methyl-cholanthrene in radiation induced carcinogenesis.

The inducibility of pulmonary microsomal enzymes and the biological effects of chronic induction by 5-6 benzoflavone and methylcholanthrene were compared in normal and precancerous rats. Two important points were shown out: a dose of 6000 WLM resulted in a permanent modification of the pulmonary microsomal enzymatic pool and 5-6 benzoflavon was a strong co-factor of radiation induced carcinogenesis. This synergistic action was demonstrated by a much shorter latency, moreover neo-formed tissue and epidermoid cancers with a particular morphology were observed. In all the cases cancers appeared within 100 days following the beginning of the chemical treatment.

Animals↗
PubMed1974

Microbiological study of a hypersaline lake in French Somaliland.

In a study of a lake having a higher concentration of salts than the Dead Sea, all of the heterotrophic bacteria isolated were aerobes; no strictly anaerobic strains were found. Ninety percent of the strains were euryhalines and ten percent were strict halophiles. The extreme halophiles belonged to the species Halobacterium trapanicum and Halococcus morrhuae.

Aerobiosis↗
PubMedDate not supplied

[Ebola virus three years later (author's transl)].

Sporadic cases and data from serologic surveys give evidence that Ebola virus is still active in Northern Zaïre after the first outbreak in 1976. It is also active in Southern Sudan where it is, from August 1979, responsible of a new epidemic focus. In addition, serological surveys demonstrate that its dispersion area comprises several other african countries. Physicians practising in central Africa must be aware of this fact. Serological test is necessary to confirm the diagnosis. This confirmation is necessary to obtain convalescent patient plasma, the only specific treatment. The clinical, epidemiological and virological aspects of Ebola virus disease are reviewed as well as precautionary measures to be taken by medical and nursing staff to avoid infection.

Animals↗
PubMedDate not supplied

[Cutaneous South-American Leishmaniasis. Parasitological and serological diagnosis by indirect immunofluorescence and enzyme linked immunoassay (ELISA). 94 cases].

A parasitological (direct test and culture) and serological (IIF and ELISA) survey was carried out in 94 soldiers infested by a cutaneous South American leishmaniasis during a training in the guyanese forest. 52 p.c of the parasitological tests were positive, direct test being much more sensitive than cultures. By this technique, Leishmania Viannia guyanensis was detected 8 times, and Leishmania Viannia braziliensis twice. I.I.F. was negative in all cases because the utilization of a non-homologous antigen in the promastigote form and of the condition of its preparation. ELISA test utilizing the same antigen in a soluble form was specific and its sensitivity was 52 p.c. This technique was positive in 52 p.c of the cases, corroborating some diagnosis for which parasitological test was negative. 66 p.c of the total cases were confirmed.

Animals↗
PubMedDate not supplied

[Focus on Schistosoma intercalatum].

Area of frequent occurrence of Schistosoma intercalatum is limited to few countries along the Guinea Gulf although the main intervening agents, Bulinus globosus, Bulinus forskalii are dispersed all over Africa. Reservoir of Schistosoma intercalatum is only human and its cycle is difficult to keep up in test animals. Clinical manifestations are, the most often, a simultaneous inflammation of the rectum and sigmoid. Diagnosis is based on the presence of ova with terminal spine in feces or in biopsies of rectal mucosae. Serology, not specific of this species, eases finding of low infestations. Treatment is based on Praziquantel.

Africa, Central↗
PubMedDate not supplied

[Lassa fever].

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Antibodies, Viral↗
PubMedDate not supplied

[Arbovirus infections].

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Arbovirus Infections↗
PubMedDate not supplied

[Yellow fever].

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Africa↗
PubMedDate not supplied

[Training in epidemiology at the Institute of Tropical Medicine of the Army Health Service. Experience over 4 years].

The authors described the training in epidemiology received by 185 Army medical doctors attached for instruction to the I.M.T.S.S.A. since 1981. Statistical methodology, basic epidemiology, and applied epidemiology are taught in such way that Army medical doctors are better capable of rationalizing and strengthening their action of prevention in their posting either in France or seconded to developing countries. Description of pedagogical targets is underlined as well as methodology of control and evaluation of progress towards these targets. The authors are also able to appreciate, in terms of the level of capacity of the personnel trained, the severity of the consequences either of a strengthening of the pedagogical targets or of a reduction. When the reform of medical education and training imposes very often such an alternative, the authors point out how the leading opinion of the ones who utilize the services of the personnel should be taken into full consideration prior to any decision.

Epidemiology↗