Biomedical subjects

D Clements

Publications and source records attributed to D Clements.

At least 73 records · Page 4Linked to original sources

PubMed1986

Iodinated cholylglycyltyrosine: a new agent for hepatobiliary imaging.

The characteristics of radiolabelled cholylglycyltyrosine (CGT), a recently synthesised bile acid, were studied. 125I-CGT-Na was found to have a short plasma half-life of 1.6 +/- 0.4 min in rats and 3.1 +/- 0.7 min in dogs. Biliary clearance studies showed the cumulative biliary output of the tracer over 20 min in rats to be 95.7% of the total dose administered, with a mean biliary transit time (50% retention time) of 4.0 +/- 0.1 min, i.e. similar to the biliary kinetics of taurocholate. 131I-CGT-Na proved to be satisfactory for hepatobiliary imaging in rats and dogs at doses of 35 microCi (1.3 MBq) in rats and 90 microCi (3.3 MBq) in dogs. Satisfactory hepatic images were also obtained in rats that had high bilirubin levels produced by obstruction or the recycling of bile. These results show that CGT has better pharmacokinetics than currently used hepatobiliary imaging agents, and that this new compound may be useful in scintigraphy even in the presence of jaundice.

Animals↗

PubMed1986

Epithelioid haemangioendothelioma. A case report.

Epithelioid haemangioendothelioma of the liver is an extremely rare tumour which has only recently been recognised. This report describes the clinical, radiological and histological findings in a case of a primary epithelioid haemangioendothelioma of the liver. The case highlights some of the difficulties in establishing the diagnosis, and in its differentiation from Budd-Chiari syndrome and veno-occlusive disease. The patient has subsequently undergone successful orthotopic hepatic transplantation.

Diagnosis, Differential↗

PubMed1986

Effect of somatostatin on oesophageal variceal pressure assessed by direct measurement.

The effect of a single bolus of somatostatin on oesophageal variceal pressure has been studied in 7 patients with cirrhosis and 5 patients with non-cirrhotic portal hypertension using a non-invasive variceal pressure gauge. Both groups of patients demonstrated similar reductions in variceal pressure with all subjects demonstrating a fall. The timing, duration and magnitude of this reduction in variceal pressure in response to somatostatin showed considerable individual variation which may explain the previous reports of a variable response to treatment of variceal haemorrhage with somatostatin. This individual variation should be borne in mind in the planning of future studies in the treatment of oesophageal variceal haemorrhage. The pneumatic pressure gauge allows the non-invasive study of the effects of drugs on variceal and portal pressure.

Esophageal Diseases↗

PubMed1986

Severe bile duct lesions without biochemical evidence of cholestasis in a case of sclerosing cholangitis.

We report a patient with very marked cholangiographic changes of sclerosing cholangitis with normal serum alkaline phosphatase and no other detectable biochemical evidence of cholestasis. He has remained asymptomatic and still has no biochemical evidence of cholestasis despite follow-up over 3 years. This case demonstrates that patients with sclerosing cholangitis may have normal liver function tests including serum alkaline phosphatase, that asymptomatic sclerosing cholangitis may therefore be under diagnosed, and that severe radiological changes of sclerosing cholangitis may not necessarily be associated with a poor prognosis.

Cholangiopancreatography, Endoscopic Retrograde↗

PubMed1986